scholarly journals Novel Tissue Types for the Development of Genomic Biomarkers

Biomarker ◽  
10.5772/38512 ◽  
2012 ◽  
Author(s):  
Zinaida Sergueeva ◽  
Heather Collins ◽  
Sally Dow ◽  
Mollie McWhorter ◽  
Mark L.
Keyword(s):  
Genomic Biomarkers

2243 COMBINED VALUE OF GENOMIC BIOMARKERS AND CAPRA-S IN PREDICTING PROSTATE CANCER DEATH IN A HIGH-RISK SURGICAL COHORT

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Matthew Cooperberg ◽  
Anamaria Crisan ◽  
Anirban Mitra ◽  
Mercedeh Ghadessi ◽  
Christine Buerki ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Cancer Death ◽  
Genomic Biomarkers ◽  
Prostate Cancer Death

scholarly journals Genomic Biomarkers for Depression: Feature-Specific and Joint Biomarkers

2010 ◽  
Vol 2 (3) ◽  
pp. 419-434 ◽  
Author(s):  
Abel Tilahun ◽  
Dan Lin ◽  
Ziv Shkedy ◽  
Helena Geys ◽  
Ariel Alonso ◽  
...  
Keyword(s):  
Genomic Biomarkers

scholarly journals Differential transcriptomics in sarcoidosis lung and lymph node granulomas with comparisons to pathogen-specific granulomas

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Nancy G. Casanova ◽  
Manuel L. Gonzalez-Garay ◽  
Belinda Sun ◽  
Christian Bime ◽  
Xiaoguang Sun ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Mediastinal Lymph Node ◽  
Immunological Response ◽  
Functional Enrichment ◽  
Genomic Biomarkers ◽  
Genomic Markers ◽  
Embedded Blocks ◽  
Granulomatous Diseases

Abstract Rationale Despite the availability of multi-“omics” strategies, insights into the etiology and pathogenesis of sarcoidosis have been elusive. This is partly due to the lack of reliable preclinical models and a paucity of validated biomarkers. As granulomas are a key feature of sarcoidosis, we speculate that direct genomic interrogation of sarcoid tissues, may lead to identification of dysregulated gene pathways or biomarker signatures. Objective To facilitate the development sarcoidosis genomic biomarkers by gene expression profiling of sarcoidosis granulomas in lung and lymph node tissues (most commonly affected organs) and comparison to infectious granulomas (coccidiodomycosis and tuberculosis). Methods Transcriptomic profiles of immune-related gene from micro-dissected sarcoidosis granulomas within lung and mediastinal lymph node tissues and compared to infectious granulomas from paraffin-embedded blocks. Differentially-expressed genes (DEGs) were profiled, compared among the three granulomatous diseases and analyzed for functional enrichment pathways. Results Despite histologic similarities, DEGs and pathway enrichment markedly differed in sarcoidosis granulomas from lymph nodes and lung. Lymph nodes showed a clear immunological response, whereas a structural regenerative response was observed in lung. Sarcoidosis granuloma gene expression data corroborated previously reported genomic biomarkers (STAB1, HBEGF, and NOTCH4), excluded others and identified new genomic markers present in lung and lymph nodes, ADAMTS1, NPR1 and CXCL2. Comparisons between sarcoidosis and pathogen granulomas identified pathway divergences and commonalities at gene expression level. Conclusion These findings suggest the importance of tissue and disease-specificity evaluation when exploring sarcoidosis genomic markers. This relevant translational information in sarcoidosis and other two histopathological similar infections provides meaningful specific genomic-derived biomarkers for sarcoidosis diagnosis and prognosis.

scholarly journals Proteomic and genomic biomarkers for Non‐Small Cell Lung Cancer: Peroxiredoxin, Haptoglobin, and Alpha‐1 antitrypsin

2020 ◽  
Vol 9 (11) ◽  
pp. 3974-3982 ◽  
Author(s):  
Zahra Najafi ◽  
Abdolreza Mohamadnia ◽  
Rahim Ahmadi ◽  
Minoo Mahmoudi ◽  
Naghmeh Bahrami ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Genomic Biomarkers ◽  
Alpha 1 Antitrypsin
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