scholarly journals The New Model of Carcinogenesis: The Cancer Stem Cell Hypothesis

Carcinogen ◽  
10.5772/38324 ◽  
2012 ◽  
Author(s):  
Brenda Loaiza ◽  
Emilio Rojas ◽  
Mahara Valverde
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
New Model ◽  
Cancer Stem Cell Hypothesis

scholarly journals Review Paper: Implications of the “Cancer Stem Cell” Hypothesis on Murine Models of Colon Cancer and Colitis-associated Cancer

2009 ◽  
Vol 46 (5) ◽  
pp. 819-835 ◽  
Author(s):  
M. J. Hynes ◽  
K. M. Huang ◽  
E. H. Huang
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Murine Models ◽  
New Paradigm ◽  
Cancer Stem Cell Hypothesis ◽  
Molecular Events ◽  
Invaluable Tool ◽  
Relationship Of ◽  
The Relationship

The use of murine models to investigate human diseases has been an invaluable tool. In the areas of inflammation and oncogenesis, such models have provided unique insights into pathogenesis and mechanisms to evaluate potential therapy. As such, one facet of these disease processes links inflammation and cancer. Inflammation is associated with at least 15% of the world's malignancies. One example of this relationship is documented in the association between colitis and colorectal cancer. To date, the precise molecular events linking inflammation and cancer remain unclear. A new paradigm that may bridge these processes includes the cancer stem cell hypothesis. In this review, murine models of colitis, colon cancer, and colitis-associated cancer are discussed in reference to the potential of this paradigm to clarify the relationship of these devastating diseases.

scholarly journals Recasting the Cancer Stem Cell Hypothesis: Unification Using a Continuum Model of Microenvironmental Forces

2019 ◽  
Vol 5 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Jacob G. Scott ◽  
Andrew Dhawan ◽  
Anita Hjelmeland ◽  
Justin Lathia ◽  
Anastasia Chumakova ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Continuum Model ◽  
Cancer Stem Cell Hypothesis

scholarly journals Decoding the cancer stem cell hypothesis in glioblastoma

CNS Oncology ◽  
2013 ◽  
Vol 2 (4) ◽  
pp. 319-330 ◽  
Author(s):  
James S Hale ◽  
Maksim Sinyuk ◽  
Jeremy N Rich ◽  
Justin D Lathia
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Stem Cell Hypothesis

Cancer Stem Cell Hypothesis for Therapeutic Innovation in Clinical Oncology? Taking the Root Out, Not Chopping the Leaf

2016 ◽  
Vol 20 (12) ◽  
pp. 681-691 ◽  
Author(s):  
Kevin Dzobo ◽  
Dimakatso Alice Senthebane ◽  
Arielle Rowe ◽  
Nicholas Ekow Thomford ◽  
Lamech M. Mwapagha ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Clinical Oncology ◽  
Cancer Stem Cell Hypothesis
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