scholarly journals Development of the Immune System - Early Nutrition and Consequences for Later Life

10.5772/37902 ◽  
2012 ◽  
Author(s):  
JoAnn Kerperien ◽  
Bastiaan Schouten ◽  
Gnther Boehm ◽  
Linette E.M. ◽  
Johan Garssen ◽  
...  
Keyword(s):  
Immune System ◽  
Later Life ◽  
Early Nutrition

scholarly journals Effects of early nutrition and sanitary conditions on antibody levels in early and later life of broiler chickens

2021 ◽  
Vol 117 ◽  
pp. 103954
Author(s):  
M.S. Hollemans ◽  
G. de Vries Reilingh ◽  
S. de Vries ◽  
H.K. Parmentier ◽  
A. Lammers
Keyword(s):  
Broiler Chickens ◽  
Later Life ◽  
Early Nutrition ◽  
Antibody Levels ◽  
Sanitary Conditions

Pain and immunity

2021 ◽  
pp. 67-71
Author(s):  
Simon Beggs
Keyword(s):  
Nervous System ◽  
Immune System ◽  
Early Life ◽  
System Development ◽  
Later Life ◽  
Nervous System Development ◽  
Neuronal Function ◽  
Neuronal Homeostasis ◽  
Neuroimmune Interactions ◽  
The Central Nervous System

The central nervous system (CNS) and immune system are inextricably linked. The complexity of their interactions is still being unraveled, but the list of processes mediated wholly or in part by neuroimmune interactions continues to grow. The influence of the immune system is crucial for normal nervous system development both pre- and postnatally, for maintaining neuronal homeostasis in the mature CNS and modulating synaptic plasticity. Aberrations in this crosstalk have been implicated in many neurodevelopmental and psychiatric disorders. It is not feasible to explore neuronal function at any point in the lifespan, in health or disease, without considering the influence of the immune system. In the adult animal it is now well established that pain chronicity is maintained by immune influence upon the neuronal nociceptive system, although, fascinatingly, there is now evidence for a marked sexual dimorphism in how the immune and nervous systems interact. This holds true for pain in early life, where the two still-developing systems provide a very different environment to mediate nociception and pain. Of particular interest is how the immune system and sex interact to early life painful events to prime pain responses in later life.

scholarly journals Effects of Early Nutrition and Sanitary Conditions on Oral Tolerance and Antibody Responses in Broiler Chickens

2020 ◽  
Vol 7 (4) ◽  
pp. 148 ◽  
Author(s):  
Maarten S. Hollemans ◽  
Ger de Vries Reilingh ◽  
Sonja de Vries ◽  
Henk K. Parmentier ◽  
Aart Lammers
Keyword(s):  
Immune System ◽  
Growth Performance ◽  
Broiler Chickens ◽  
Oral Tolerance ◽  
Feeding Strategy ◽  
Later Life ◽  
Antibody Responses ◽  
Oral Exposure ◽  
Antibody Levels ◽  
Sanitary Conditions

Greater antigenic exposure might accelerate activation and maturation of the humoral immune system. After hatch, commercial broiler chickens can have early (EN) or delayed (DN) access to nutrition, up to 72 h after hatch. The immune system of EN versus DN broilers is likely more exposed to antigens after hatch. This might contribute to activation and maturation of the immune system, but might also influence the development of oral tolerance, thereby altering later life antibody responses. We studied antibody (IgM, IgY, IgA) responses between 21 and 42 d of age in fast-growing EN and DN broilers, kept under low (LSC) or high sanitary conditions (HSC). In a first experiment (n = 51 broilers), we tested whether early oral exposure to bovine serum albumin (BSA) affected later life antibody responses towards BSA and a novel antigen—rabbit γ-globulin (RGG), under HSC. In a second experiment, a total of 480 EN and DN broilers were housed under either LSC or HSC, and we studied antibody responses against both BSA and RGG (n = 48 broilers per treatment) and growth performance. Broilers kept under LSC versus HSC, had higher antibody levels and their growth performance was severely depressed. Interactions between feeding strategy (EN versus DN) and sanitary conditions, or main effects of feeding strategy, on natural and specific antibody levels, and growth performance were not observed. Levels of IgA were elevated in EN versus DN broilers, in experiment I and in batch 2 of experiment II, but not in the other batches of experiment II. We concluded that EN versus DN contributes minimally to the regulation of antibody responses, irrespective of antigenic pressure in the rearing environment.

scholarly journals Early nutrition and leptin concentrations in later life

2002 ◽  
Vol 75 (6) ◽  
pp. 993-999 ◽  
Author(s):  
Atul Singhal ◽  
I Sadaf Farooqi ◽  
Stephen O'Rahilly ◽  
Tim J Cole ◽  
Mary Fewtrell ◽  
...  
Keyword(s):  
Later Life ◽  
Early Nutrition

Interplay between early-life malnutrition, epigenetic modulation of the immune function and liver diseases

2019 ◽  
Vol 32 (1) ◽  
pp. 128-145 ◽  
Author(s):  
Sabrina Campisano ◽  
Anabela La Colla ◽  
Stella M. Echarte ◽  
Andrea N. Chisari
Keyword(s):  
Metabolic Syndrome ◽  
Immune System ◽  
Environmental Factors ◽  
Early Life ◽  
Critical Role ◽  
Later Life ◽  
Covalent Modification ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Epigenetic Modulation

AbstractEarly-life nutrition plays a critical role in fetal growth and development. Food intake absence and excess are the two main types of energy malnutrition that predispose to the appearance of diseases in adulthood, according to the hypothesis of ‘developmental origins of health and disease’. Epidemiological data have shown an association between early-life malnutrition and the metabolic syndrome in later life. Evidence has also demonstrated that nutrition during this period of life can affect the development of the immune system through epigenetic mechanisms. Thus, epigenetics has an essential role in the complex interplay between environmental factors and genetics. Altogether, this leads to the inflammatory response that is commonly seen in non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome. In conjunction, DNA methylation, covalent modification of histones and the expression of non-coding RNA are the epigenetic phenomena that affect inflammatory processes in the context of NAFLD. Here, we highlight current understanding of the mechanisms underlying developmental programming of NAFLD linked to epigenetic modulation of the immune system and environmental factors, such as malnutrition.

Immunological footprint: the development of a child's immune system in environments rich in microorganisms and parasites

Parasitology ◽  
2011 ◽  
Vol 138 (12) ◽  
pp. 1508-1518 ◽  
Author(s):  
YENNY DJUARDI ◽  
LINDA J. WAMMES ◽  
TANIAWATI SUPALI ◽  
ERLIYANI SARTONO ◽  
MARIA YAZDANBAKHSH
Keyword(s):  
Immune System ◽  
Environmental Factors ◽  
Later Life ◽  
Third Party ◽  
Middle Income ◽  
Middle Income Countries ◽  
Geographical Regions ◽  
Micro Organisms ◽  
The Impact

SUMMARYThe shaping of a child's immune system starts in utero, with possible long-term consequences in later life. This review highlights the studies conducted on the development of the immune system in early childhood up to school-age, discussing the impact that environmental factors may have. Emphasis has been put on studies conducted in geographical regions where exposure to micro-organisms and parasites are particularly high, and the effect that maternal exposures to these may have on an infant's immune responses to third-party antigens. In this respect we discuss the effect on responses to vaccines, co-infections and on the development of allergic disorders. In addition, studies of the impact that such environmental factors may have on slightly older (school) children are highlighted emphasizing the need for large studies in low to middle income countries, that are sufficiently powered and have longitudinal follow-up components to understand the immunological footprint of a child and the consequences throughout life.

The managed immune system: protecting the womb to delay the tomb

2008 ◽  
Vol 27 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Rodney R Dietert ◽  
Michael S Piepenbrink
Keyword(s):  
Immune System ◽  
Health Risks ◽  
Functional Capacity ◽  
Developmental Toxicity ◽  
Later Life ◽  
Environmental Chemicals ◽  
Late Gestation ◽  
Early Postnatal Development ◽  
The Status ◽  
Novel Target

The developing immune system serves as a novel target for disruption by environmental chemicals and drugs, and one that can significantly influence later-life health risks. Specific immune maturational events occur during critical windows of pre- and early postnatal development that are not effectively modeled using adult exposure-assessment or general developmental toxicity screens. The range of postnatal health risks linked to developmental immunotoxicity (DIT) is influenced, in part, by the natural progression of prenatal-neonatal development. In this progression, the pregnancy itself imposes a Th2-bias in utero, and this produces a delay in the acquisition of Th1 functional capacity in the newborn. The status of Th1 regulatory and Th17 populations may also be important in immune function/dysfunction considerations. The necessary shift from a Th2 preferred capacity in late gestation to a more balance functional capacity in the neonate can be disrupted by xenobiotics leaving the child with increased vulnerability to a range of potential diseases. Knowledge of environmental factors that facilitate effective immune functional maturation as well as those xenobiotics capable of disrupting the process is important in strategies to reduce the incidence of diseases such as childhood asthma. Because hormesis has been shown to be an important factor in modulation of the adult immune system, it becomes even more important to understand potentially opposing dose-response effects for the immune system of the fetus, neonate, and juvenile. The direct linkage between immune dysfunction and chronic disease has become abundantly apparent in recent years. Therefore, a more comprehensive and effective approach for the protection of the developing immune system can help to reduce the incidence of later-life chronic diseases.

scholarly journals Gut–neuroimmune interactions: the unexpected role of the immune system in brain development

2019 ◽  
Vol 41 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Simon Spichak ◽  
Timothy G. Dinan ◽  
John F. Cryan
Keyword(s):  
Immune System ◽  
Brain Development ◽  
Neuronal Development ◽  
Inflammatory Responses ◽  
Later Life ◽  
Innate Immune ◽  
Brain Health ◽  
Cytokines And Chemokines ◽  
The Brain

How does the immune system impact brain development? The exciting and somewhat unexpected relationship between the immune system and the brain has become one of the most fascinating topics in neuroscience. Even though the immune system was initially implicated in resolving viral and bacterial threats, it is now becoming more evident that it also plays a role in processes in the brain, both under healthy and pathological conditions. This novel role of the immune system in brain health has been implicated in various psychopathologies where neurodevelopment, stress and mood are central. In particular, its role in healthy brain development is becoming more evident, and understanding neuroimmune communication is becoming crucial in treating neurodevelopmental and mood disorders in later life. In the brain, glia function as part of the innate immune system and are programmed to respond to pathogens and physical injury. They also play an important role in neuronal development and pruning. These cells communicate with and respond to chemical signals, such as cytokines and chemokines, which can then initiate or downregulate inflammatory responses. Finally, the trillions of microbes residing in the gut can also stimulate cytokine and chemokine responses in the periphery and play an important role in both immunity and brain development.

Epigenetic Regulation of Early Nutrition on Immune System

2019 ◽  
pp. 1067-1078
Author(s):  
Lorella Paparo ◽  
Rosita Aitoro ◽  
Rita Nocerino ◽  
Carmen di Scala ◽  
Margherita Di Costanzo ◽  
...  
Keyword(s):  
Immune System ◽  
Epigenetic Regulation ◽  
Early Nutrition
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