scholarly journals Toxicity Analysis of Effluent Released During Recovery of Metals from Polymetallic Sea Nodules Using Fish Haematological Parameters

10.5772/37489 ◽  
2012 ◽  
Author(s):  
Huma Vaseem ◽  
T.K. Banerjee
Keyword(s):  
Haematological Parameters ◽  
Toxicity Analysis ◽  
Polymetallic Sea Nodules

Effect of carbofuran on quantitative and qualitative alterations in haemolymph of larva of Oryctes rhinoceros L. (Coleoptera: Scarabaeidae)

ENTOMON ◽  
2020 ◽  
Vol 44 (4) ◽  
pp. 293-300
Author(s):  
V.S. Salini
Keyword(s):  
Oral Route ◽  
Toxicity Assessment ◽  
Haematological Parameters ◽  
Oryctes Rhinoceros ◽  
Total Haemocyte Count ◽  
Differential Haemocyte Count ◽  
Third Instar Larvae

Investigation to evaluate the toxicity of carbofuran pesticides on haematological parameters of third instar larvae of Oryctes rhinoceros L. Indicated alterations in total haemocyte count and differential haemocyte count for toxicity assessment. Various doses of carbofuran (0.05g, 0.010g and 0.015 g) applied on insect through oral route and its impact after 24 hours of its application revealed that various doses of carbofuran exert specific alterations in both total and differential haemocytes of insect haemolymph.

Comparative seabird diving physiology: first measures of haematological parameters and oxygen stores in three New Zealand Procellariiformes

2015 ◽  
Vol 523 ◽  
pp. 187-198 ◽  
Author(s):  
BJ Dunphy ◽  
GA Taylor ◽  
TJ Landers ◽  
RL Sagar ◽  
BL Chilvers ◽  
...  
Keyword(s):  
New Zealand ◽  
Haematological Parameters ◽  
Diving Physiology ◽  
Oxygen Stores

Anti-annexin A5, Antiphosphatidylinositol Antibodies and Haematological Parameters in Preeclampsia Patients: A Case-Control Study

2020 ◽  
Vol 16 ◽  
Author(s):  
Wan Haslindawani Wan Mahmood ◽  
Md Asiful Islam ◽  
Mimi Azreen Abdullah ◽  
Noor Haslina Mohd Noor ◽  
Indhira Subbiah ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Activated Partial Thromboplastin Time ◽  
Haematological Parameters ◽  
Annexin A5 ◽  
Glycoprotein I ◽  
Mild Preeclampsia ◽  
Routine Assay ◽  
Low Prevalence ◽  
Control Study

Background: Prevalence and the risk of common antiphospholipid antibodies (aPLs) such as lupus anticoagulant (LA), anticardiolipin (aCL) and anti-β2-glycoprotein I (β2-GPI) antibodies in preeclampsia is a matter of debate. Recently, interests have expanded in evaluating the risks of presenting non-classic aPLs in preeclampsia patients. Objective: The objective of this case-control study was to evaluate some haematological parameters besides assessing the presence of anti-annexin A5 and antiphosphatidylinositol (aPI) antibodies in preeclampsia patients compared to nonpreeclampsia subjects. Methods: From two hospitals in Malaysia, a total of 84 subjects were recruited in this case-control study including 42 preeclampsia and 42 age-matched non-preeclampsia subjects. Some haematological parameters [i.e., haemoglobin, total white blood cell, platelet, prothrombin time and activated partial thromboplastin time (APTT)] were assessed besides screening for anti-annexin A5 and aPI antibodies. Results: Among the haematological parameters, APTT was significantly high in mild preeclampsia when compared to severe preeclampsia subjects (p=0.007). IgG anti-annexin A5 antibody was detected in a single preeclampsia subject only (2.4%) and none in non-preeclampsia subjects. Conclusion: Because of the low prevalence, non-classic aPLs should not be considered as a risk factor in developing preeclampsia and not justifiable to consider as a routine assay in pregnant women.

Design of potential IKK-β inhibitors using molecular docking and molecular dynamics techniques for their anti-cancer potential

2020 ◽  
Vol 16 ◽  
Author(s):  
Salam Pradeep Singh ◽  
Iftikar Hussain ◽  
Bolin Kumar Konwar ◽  
Ramesh Chandra Deka ◽  
Chingakham Brajakishor Singh
Keyword(s):  
Molecular Dynamics ◽  
Molecular Docking ◽  
Md Simulation ◽  
Inflammatory Diseases ◽  
Binding Free Energy ◽  
Anti Cancer ◽  
Dietary Phytochemicals ◽  
Toxicity Analysis ◽  
The Stability ◽  
Stable Trajectory

Aim and Objective: To evaluate a set of seventy phytochemicals for their potential ability to bind the inhibitor of nuclear factor kappaB kinase beta (IKK-β) which is a prime target for cancer and inflammatory diseases. Materials and Methods: Seventy phytochemicals were screened against IKK-β enzyme using DFT-based molecular docking technique and the top docking hits were carried forward for molecular dynamics (MD) simulation protocols. The adme-toxicity analysis was also carried out for the top docking hits. Results: Sesamin, matairesinol and resveratrol were found to be the top docking hits with a total score of -413 kJ/mol, -398.11 kJ/mol and 266.73 kJ/mol respectively. Glu100 and Gly102 were found to be the most common interacting residues. The result from MD simulation observed a stable trajectory with a binding free energy of -107.62 kJ/mol for matairesinol, -120.37 kJ/mol for sesamin and -40.56 kJ/mol for resveratrol. The DFT calculation revealed the stability of the compounds. The ADME-Toxicity prediction observed that these compounds fall within the permissible area of Boiled-Egg and it does not violate any rule for pharmacological criteria, drug-likeness etc. Conclusion: The study interprets that dietary phytochemicals are potent inhibitors of IKK-β enzyme with favourable binding affinity and less toxic effects. In fact, there is a gradual rise in the use of plant-derived molecules because of its lesser side effects compared to chemotherapy. The study has also provided an insight by which the phytochemicals inhibited the IKK-β enzyme. The investigation would also provide in understanding the inhibitory mode of certain dietary phytochemicals in treating cancer.

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