scholarly journals Food Borne Carcinogens: A Dead End?

Carcinogen ◽  
10.5772/36576 ◽  
2012 ◽  
Author(s):  
Rosa Busquets
Keyword(s):  
2012 ◽  
Vol 2 (1) ◽  
pp. 49-80
Author(s):  
Evrea Ness-Bergstein

In Lewis’ transposition of Milton’s Paradise to a distant world where Adam and Eve do not succumb to Satan, the structure of Eden is radically different from the enclosed garden familiar to most readers. In the novel Perelandra (1944), C.S. Lewis represents the Garden of Eden as an open and ‘shifting’ place. The new Garden of Eden, with Adam and Eve unfallen, is a place of indeterminate future, excitement, growth, and change, very unlike the static, safe, enclosed Garden—the hortus conclusus of traditional iconography—from which humanity is not just expelled but also, in some sense, escapes. The innovation is not in the theological underpinnings that Lewis claims to share with Milton but in the literary devices that make evil in Perelandra seem boring, dead-end, and repetitive, while goodness is the clear source of change and excitement.


Romanticism ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 22-35
Author(s):  
Nicola Healey

The literary career and troubled life of Derwent Moultrie Coleridge (1828–80), Derwent Coleridge's eldest son (S. T. Coleridge's first grandson) has been critically overlooked. After a period of alcohol-related, reckless behaviour at Cambridge University, he was exiled to Australia in November 1850, lest he continue to dishonour his father and the Coleridge name. Despite struggling considerably, he quickly became part of an Australian literary circle and he often contributed poems to Sydney newspapers. This essay analyses the most biographical of his poems that was published in the Australian press, ‘The Loafer's Christmas’ (1871) – a hitherto unknown poem – looking, in particular, at the dialogues in which the poem engages with his family, especially S. T. Coleridge's ‘The Rime of the Ancient Mariner’. I also contextualise ‘The Loafer's Christmas’ within nineteenth-century Australian culture. Looking at issues of exile, idleness, addiction, family, home(lessness), and religious redemption, this essay explores the ways in which Derwent Moultrie's exile proved to be both a literary liberation and a dead end, trapping him between times and spaces, real and imaginary. In so doing, I show how the lost life and writings of Derwent Moultrie Coleridge can offer us new perspectives on the Coleridge legacy.


2020 ◽  
pp. 3-4
Author(s):  
Oleg Yu. Chernykh ◽  
◽  
Vadim A. Bobrov ◽  
Sergey N. Zabashta ◽  
Roman A. Krivonos ◽  
...  

Rabies remains a constant threat to humanity in many parts of the world. At the same time, scientifically grounded antiepizootic measures should be based on the peculiarities of the regional epizootology of this zooanthroponosis. The authors studied the epizootological and statistical reporting data of the Kropotkin Regional Veterinary Laboratory, presented an analysis of the registration of rabies in animals in Krasnodar region. From the obtained data, it should be noted that despite the wide range of animals involved in the epizootic process of rabies infection in Krasnodar region, dogs, cats and foxes play a major role in the reservation and spread of infection, which account for 78.6. Of the total number of registered cases, 15.5% falls on foxes, that indicates the natural focus of the disease, along with the manifestation of the disease in an urban form. At the same time, stray and neglected dogs and cats, which occupy a significant place among the total number of sick animals, are also sources and spread of the infection. Thus farm animals (8.3% of the total number of infected animals) are a biological dead end for the infection. Isolated cases of the disease were noted in muskrat, donkey, raccoon, raccoon dog, marten, ferret and jackal. The authors also established the specific morbidity of various animal species with rabies infection, that is an important aspect in the development and implementation of antiepizootic measures complex


1979 ◽  
Vol 32 (3) ◽  
pp. 58-62
Author(s):  
David Coursen
Keyword(s):  

2007 ◽  
Vol 30 (4) ◽  
pp. 93
Author(s):  
I Sekirov ◽  
N Tam ◽  
M Robertson ◽  
C Lupp ◽  
B Finlay

Background: During our lifetimes we develop a very complex set of interactions with the multitude of microorganisms colonizing our bodies. In the gastrointestinal system, the microbiota is highly important for morphological development, nutrition, and protection against infectious diseases. The gastrointestinal pathogens, enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) and Salmonella enterica serovar Typhimurium (ST) are food-borne pathogens that cause much morbidity and mortality worldwide. Citrobacter rodentium (Cr) is a mouse pathogen that is used in small animal models to mimic EHEC and EPEC infections. Methods: We began to characterize the contribution of intestinal microbiota to the progression of these infections. Two main phyla comprise the majority of mouse intestinal microbiota: Bacteroidetes and Firmicutes. Bacteria from a number of additional phyla are also present in smaller numbers; among them γ-Proteobacteria class, belonging to Proteobacteria phylum, is note-worthy as this class harbours many intestinal pathogens, such as ST and Cr. The mouse intestinal microbiota was perturbed using tetracycline (Tet) and streptomycin (Sm) to increase the proportion of Bacteroidetes in the colonic microbiota, and using vancomycin (Vanc) to create a predominance of Firmicutes. The mice with this perturbed microbiota were infected with ST to investigate the resultant pathology and virulence characteristics, and any additional shifts in microbiota as a result of infection. Results: Treatment of mice with Sm and Vanc was found to decrease the resistance of mice to colonization with ST, while Tet-treated mice exhibited unchanged colonization resistance. Treatment of mice with gradually increasing doses of Sm, which gradually augmented the proportion of CFB bacteria in the microbiota, resulted in progressively increasing colonization of mice by ST, as well as a step-wise increase in the ST-induced typhlitis, associated with higher levels of inflammatory markers IL-6 and KC. The increasing levels of ST colonization following both Sm and Vanc treatment were associated with an increase in the proportion of γ-Proteobacteria in the cecal and colonic microbiota, as well as a decrease in the total bacterial numbers in both organs. Conclusions: It is evident that the intestinal microbiota plays a significant role in the host’s response to infection with enteric pathogens, and its composition and numbers are also affected by the offending bacteria. Elucidation of the details regarding the contribution of the microbiota to infectious disease progression will offer novel targets for the future design of superior prevention and treatment methods.


Sign in / Sign up

Export Citation Format

Share Document