scholarly journals Adult Stem Cells in Tissue Homeostasis and Disease

10.5772/33941 ◽  
2012 ◽  
Author(s):  
Elena Lazzeri ◽  
Anna Peired ◽  
Lara Ballerini ◽  
Laura Lasagni
Keyword(s):  
Stem Cells ◽  
Adult Stem Cells ◽  
Tissue Homeostasis

scholarly journals Author response: Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

2016 ◽  
Author(s):  
Erin L Davies ◽  
Kai Lei ◽  
Christopher W Seidel ◽  
Amanda E Kroesen ◽  
Sean A McKinney ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adult Stem Cells ◽  
Tissue Homeostasis ◽  
Author Response ◽  
Embryonic Origin

scholarly journals Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Junjun Jing ◽  
Jifan Feng ◽  
Jingyuan Li ◽  
Hu Zhao ◽  
Thach-Vu Ho ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Wnt Signaling ◽  
Adult Stem Cells ◽  
Cell Types ◽  
Tissue Homeostasis ◽  
Canonical Wnt Signaling ◽  
Multiple Organs ◽  
Canonical Wnt

Interaction between adult stem cells and their progeny is critical for tissue homeostasis and regeneration. In multiple organs, mesenchymal stem cells (MSCs) give rise to transit amplifying cells (TACs), which then differentiate into different cell types. However, whether and how MSCs interact with TACs remains unknown. Using the adult mouse incisor as a model, we present in vivo evidence that TACs and MSCs have distinct genetic programs and engage in reciprocal signaling cross talk to maintain tissue homeostasis. Specifically, an IGF-WNT signaling cascade is involved in the feedforward from MSCs to TACs. TACs are regulated by tissue-autonomous canonical WNT signaling and can feedback to MSCs and regulate MSC maintenance via Wnt5a/Ror2-mediated non-canonical WNT signaling. Collectively, these findings highlight the importance of coordinated bidirectional signaling interaction between MSCs and TACs in instructing mesenchymal tissue homeostasis, and the mechanisms identified here have important implications for MSC–TAC interaction in other organs.

scholarly journals TrpA1 is a shear stress mechanosensing channel regulating intestinal homeostasis in Drosophila

2022 ◽  
Author(s):  
Jiaxin Gong ◽  
Niraj K. Nirala ◽  
Jiazhang Chen ◽  
Fei Wang ◽  
Pengyu Gu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Shear Stress ◽  
Stem Cell ◽  
Adult Stem Cells ◽  
Transient Receptor Potential ◽  
Splice Variants ◽  
Tissue Growth ◽  
Tissue Homeostasis ◽  
Enteroendocrine Cells ◽  
Stress Sensing

Adult stem cells are essential for maintaining normal tissue homeostasis and supporting tissue repair. Although genetic and biochemical programs controlling adult stem cell behavior have been extensively investigated, how mechanosensing regulates stem cells and tissue homeostasis is not well understood. Here, we show that shear stress can activate enteroendocrine cells, but not other gut epithelial cell types, to regulate intestine stem cell-mediated gut homeostasis. This shear stress sensing is mediated by transient receptor potential A1 (TrpA1), a Ca2+-permeable ion channel expressed only in enteroendocrine cells among all gut epithelial cells. Genetic depletion of TrpA1 or modification of its shear stress sensing function causes reduced intestine stem cell proliferation and intestine growth. We further show that among the TrpA1 splice variants, only select isoforms are activated by shear stress. Altogether, our results suggest the naturally occurring mechanical force such as fluid passing generated shear stress regulates intestinal stem cell-mediated tissue growth by activating enteroendocrine cells, and Drosophila TrpA1 as a new shear stress sensor.

Circadian control of tissue homeostasis and adult stem cells

2014 ◽  
Vol 31 ◽  
pp. 8-15 ◽  
Author(s):  
Peggy Janich ◽  
Qing-Jun Meng ◽  
Salvador Aznar Benitah
Keyword(s):  
Stem Cells ◽  
Adult Stem Cells ◽  
Tissue Homeostasis ◽  
Circadian Control

The Hair Follicle Bulge: A Niche for Adult Stem Cells

2011 ◽  
Vol 17 (4) ◽  
pp. 513-519 ◽  
Author(s):  
Hilda Amalia Pasolli
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Wound Repair ◽  
Adult Stem Cells ◽  
Cell Types ◽  
Tissue Homeostasis ◽  
Regenerative Capacity ◽  
Multiple Cell

AbstractAdult stem cells (SCs) are essential for tissue homeostasis and wound repair. They have the ability to both self-renew and differentiate into multiple cell types. They often reside in specialized microenvironments or niches that preserve their proliferative and tissue regenerative capacity. The murine hair follicle (HF) has a specialized and permanent compartment—the bulge, which safely lodges SCs and provides the necessary molecular cues to regulate their function. The HF undergoes cyclic periods of destruction, regeneration, and rest, making it an excellent system to study SC biology.

scholarly journals Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Erin L Davies ◽  
Kai Lei ◽  
Christopher W Seidel ◽  
Amanda E Kroesen ◽  
Sean A McKinney ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adult Stem Cells ◽  
Embryonic Stem ◽  
Cell Types ◽  
Early Embryo ◽  
Tissue Homeostasis ◽  
Organ Systems ◽  
Major Organ ◽  
Undifferentiated Cells ◽  
Embryonic Origin

Planarian neoblasts are pluripotent, adult somatic stem cells and lineage-primed progenitors that are required for the production and maintenance of all differentiated cell types, including the germline. Neoblasts, originally defined as undifferentiated cells residing in the adult parenchyma, are frequently compared to embryonic stem cells yet their developmental origin remains obscure. We investigated the provenance of neoblasts during Schmidtea mediterranea embryogenesis, and report that neoblasts arise from an anarchic, cycling piwi-1+ population wholly responsible for production of all temporary and definitive organs during embryogenesis. Early embryonic piwi-1+ cells are molecularly and functionally distinct from neoblasts: they express unique cohorts of early embryo enriched transcripts and behave differently than neoblasts in cell transplantation assays. Neoblast lineages arise as organogenesis begins and are required for construction of all major organ systems during embryogenesis. These subpopulations are continuously generated during adulthood, where they act as agents of tissue homeostasis and regeneration.

scholarly journals GABA-A signaling maintains melanocyte stem cell quiescence in larval zebrafish

2019 ◽  
Author(s):  
James R. Allen ◽  
James B. Skeath ◽  
Stephen L. Johnson
Keyword(s):  
Stem Cells ◽  
Adult Stem Cells ◽  
Tissue Homeostasis ◽  
Gaba A ◽  
Larval Zebrafish ◽  
Stem Cell Quiescence ◽  
Cell Quiescence ◽  
Melanocyte Stem Cells ◽  
Necessary And Sufficient

AbstractAdult stem cells (ASCs) contribute to long-term homeostasis and regeneration of many adult tissues. Some ASCs proliferate continuously, others remain quiescent awaiting activation. To identify pathways that regulate ASC quiescence and tissue homeostasis, we study melanocyte stem cells (MSCs) that drive vertebrate pigmentation. In larval zebrafish, MSCs are quiescent, but can be recruited to regenerate the larval pigment pattern following melanocyte ablation. Through pharmacological experiments, we found that inhibition of GABA-A receptor function, specifically the GABA-A rho subtype, induces excessive melanocyte production in larval zebrafish. Conversely, pharmacological activation of GABA-A inhibited melanocyte regeneration. We used CRISPR to generate two mutant alleles of gabrr1, a subtype of GABA-A. Both alleles exhibited robust melanocyte overproduction, while conditional overexpression of gabrr1 inhibited larval melanocyte regeneration. Our data suggest that gabrr1 signaling is necessary and sufficient to maintain MSC quiescence and prevent excessive pigmentation of the larval zebrafish.

Cellular cardiomyoplasty using embryonic cardiomyocytes and adult stem cells

2005 ◽  
Vol 53 (S 3) ◽  
Author(s):  
W Röll ◽  
T Hashemi ◽  
M Breitbach ◽  
O Dewald ◽  
A Welz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adult Stem Cells ◽  
Cellular Cardiomyoplasty ◽  
Embryonic Cardiomyocytes
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