scholarly journals Antibacterial Activity of Naturally Occurring Compounds from Selected Plants

10.5772/33059 ◽  
2012 ◽  
Author(s):  
Olgica Stefanovic ◽  
Ivana Radojevic ◽  
Sava Vasic ◽  
Ljiljana Comic
Keyword(s):  
Antibacterial Activity ◽  
Naturally Occurring

scholarly journals Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study

2020 ◽  
Vol 71 (6) ◽  
pp. 267-273 ◽  
Author(s):  
Branislava D. Kocic ◽  
Dobrila M. Stankovic Dordevic ◽  
Marija V. Dimitrijevic ◽  
Marija S. Markovic ◽  
Dragoljub L. Miladinovic
Keyword(s):  
Helicobacter Pylori ◽  
Antibacterial Activity ◽  
Natural Products ◽  
Chemical Composition ◽  
Essential Oils ◽  
Principal Component ◽  
Synergistic Activity ◽  
Agglomerative Hierarchical Clustering ◽  
Naturally Occurring ◽  
H Pylori

The susceptibility of Helicobacter pylori to three essential oils (EOs), 12 naturally occurring monoterpene hydrocarbons, oxygenated and phenolic monoterpenes and three reference antibiotics were studied. Classification and comparison of essential oils and monoterpenes on the basis of their chemical composition and antibacterial activity were made by the utilization of principal component analyses (PCA) and agglomerative hierarchical clustering (AHC). The most abundant compound in the Thymus glabrescens Willd. and Thymus pulegioides L. EOs is geraniol (33.8% and 52.5%), while the main constituent in Satureja kitaibelii Wierzb. ex Heuff. EO is limonene (16,1%). The compound that was the most active against H. pylori was carvacrol. EOs of T. glabrescens and S. kitaibelii exhibit higher antibacterial ability in comparison with all monoterpenes, except carvacrol, probably based on the concept of synergistic activity of essential oil components. PCA separated essential oils based on chemical composition and explain 96.5% of the total variance in the first two principal components. Essential oils, phenolic monoterpenes and two antibiotics were classified in the same sub-cluster within AHC analyses. EOs of T. glabrescens and S. kitaibelii can be used to treat infections caused by H. pylori, as a potentially effective, cheap and safe natural products. Further research of antibacterial activity of selected monoterpenes, essential oils and standard antibiotic combinations, as well as clinical study are required.

scholarly journals Conformation-dependent Antibacterial Activity of the Naturally Occurring Human Peptide LL-37

1998 ◽  
Vol 273 (6) ◽  
pp. 3718-3724 ◽  
Author(s):  
Jan Johansson ◽  
Gudmundur H. Gudmundsson ◽  
Martı́n E. Rottenberg ◽  
Kurt D. Berndt ◽  
Birgitta Agerberth
Keyword(s):  
Antibacterial Activity ◽  
Naturally Occurring

Antibacterial Activity of the Lactoperoxidase System: A Review

1993 ◽  
Vol 56 (10) ◽  
pp. 887-892 ◽  
Author(s):  
LISA M. WOLFSON ◽  
SUSAN S. SUMNER
Keyword(s):  
Antibacterial Activity ◽  
Shelf Life ◽  
Incubation Time ◽  
Raw Milk ◽  
Medium Ph ◽  
Gram Negative ◽  
System A ◽  
Naturally Occurring ◽  
Lactoperoxidase System ◽  
Storage Times

The lactoperoxidase (LP) system is a naturally occurring system which was first discovered in raw milk. Different groups of bacteria show a varying degree of resistance to the LP system. Gram-negative catalase-positive organisms, such as pseudomonads, coliforms, salmonellae, and shigellae, are inhibited by the LP system. Depending on the medium pH, temperature, incubation time, cell density, and the particular donor, these microorganisms may be killed. It has been shown that the LP system can increase storage times of raw milk by delaying growth of psychrotrophs; perhaps this method could be used to extend the shelf life of other foods.

scholarly journals Katanosin B and Plusbacin A3, Inhibitors of Peptidoglycan Synthesis in Methicillin-ResistantStaphylococcus aureus

2001 ◽  
Vol 45 (6) ◽  
pp. 1823-1827 ◽  
Author(s):  
Hideki Maki ◽  
Kenji Miura ◽  
Yoshinori Yamano
Keyword(s):  
Cell Wall ◽  
Antibacterial Activity ◽  
Whole Cells ◽  
Gram Positive Bacteria ◽  
Peptidoglycan Synthesis ◽  
Cyclic Depsipeptide ◽  
Naturally Occurring ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

ABSTRACT Both katanosin B and plusbacin A3 are naturally occurring cyclic depsipeptide antibiotics containing a lactone linkage. They showed strong antibacterial activity against methicillin-resistantStaphylococcus aureus and VanA-type vancomycin-resistant enterococci, with MICs ranging from 0.39 to 3.13 μg/ml, as well as against other gram-positive bacteria. They inhibited the incorporation of N-acetylglucosamine, a precursor of cell wall synthesis, into peptidoglycan of S. aureus whole cells at concentrations close to their MICs. In vitro studies with a wall-membrane particulate fraction of S. aureus showed that katanosin B and plusbacin A3 inhibited the formation of lipid intermediates, with 50% inhibitory concentrations (IC50s) of 2.2 and 2.3 μg/ml, respectively, and inhibited the formation of nascent peptidoglycan, with IC50s of 0.8 and 0.4 μg/ml, respectively. Vancomycin, a well-known inhibitor of transglycosylation, did not inhibit the formation of lipid intermediates but did inhibit the formation of nascent peptidoglycan, with an IC50 of 4.1 μg/ml. Acetyl-Lys-d-Ala-d-Ala, an analog of the terminus of the lipid intermediates, effectively suppressed the inhibition of transglycosylation by vancomycin, but did not suppress those by katanosin B and plusbacin A3. These results indicate that the antibacterial activity of katanosin B and plusbacin A3 is due to blocking of transglycosylation and its foregoing steps of cell wall peptidoglycan synthesis via a mechanism differing from that of vancomycin.

scholarly journals Microbiological Studies on Naturally Present Bacteria in Camel and Buffalo Milk

2020 ◽  
pp. 562-570
Author(s):  
Amr M. Abdou ◽  
Riham H. Hedia ◽  
Shimaa T. Omara ◽  
Mai M. Kandil ◽  
M. A. Bakry ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Polymerase Chain Reaction Analysis ◽  
Buffalo Milk ◽  
Camel Milk ◽  
Lactobacillus Species ◽  
Milk Samples ◽  
Naturally Occurring ◽  
Polymerase Chain ◽  
Probiotic Lactobacilli

The aim of current study was to isolate and identify naturally occurring probiotic Lactobacillus species in buffalo milk, camel milk, and camel urine to investigate their susceptibility to antibiotics and their antibacterial activity against pathogenic bacteria. A total number of seven samples which included three milk samples from buffalo, three milk samples from camel, and one urine sample from camel were collected and used in this study. The samples were cultured, and 18 isolated strains were identified by using 16S rRNA multiplex Polymerase Chain Reaction analysis, which was performed following DNA extraction from the isolated bacteria. Buffalo and camel milk were different in their Lactobacilli content. All Lactobacilli strains that were found in both camel milk and camel urine, were also found in buffalo milk, Lactobacilli strains in camel milk and urine were generally more resistant to the antibiotic. Lactobacilli isolated from buffalo milk, camel milk, and also camel urine presented variable degrees of antibacterial activity against pathogenic bacteria. Further studies should be conducted with more samples to gain more information in the field of antibacterial activity of probiotic lactobacilli and to understand the mechanisms of their activity. Hopefully, they can be used as natural alternatives instead of synthetic antibiotics.

scholarly journals In vitro activity of naturally occurring peptides (defensins) against Listeria monocytogenes

1994 ◽  
Vol 10 (4) ◽  
pp. 440-445
Author(s):  
Maria da Graça F. Nascimento ◽  
James S. Cullor ◽  
Michael E. Selsted
Keyword(s):  
Antibacterial Activity ◽  
Listeria Monocytogenes ◽  
Water Samples ◽  
Water System ◽  
Growth Curves ◽  
Distilled Water ◽  
In Vitro Activity ◽  
Cationic Peptide ◽  
Naturally Occurring

Autoclaved distilled water samples were inoculated with L. monocytogenes strain V7 and strain VPH-1, and incubated aerobically, at 30 C for 48 hours. Each strain was tested individually, and growth curves were determined at 1, 2, 3, 4, 5, 21, 24, and 48 hours. The growth or survival of L. monocytogenes was similar for both strains, with survivors at 24 hour-incubation. The microbicidal activity of one synthetic cationic peptide (NP-2) was examined against L. monocytogenes strain V7, in a water system. Antibacterial activity of NP-2 (1, 5, and 10 g/ml) was best expressed at 60 minute-incubation, with 10 g/ml of peptide, at 30 C.

Antimicrobial Properties of Milkfat Globule Membrane Fractions†‡

2008 ◽  
Vol 71 (1) ◽  
pp. 126-133 ◽  
Author(s):  
DEBRA A. CLARE ◽  
ZUOXING ZHENG ◽  
HOSNI M. HASSAN ◽  
HAROLD E. SWAISGOOD ◽  
GEORGE L. CATIGNANI
Keyword(s):  
Antibacterial Activity ◽  
Xanthine Oxidase ◽  
Antimicrobial Properties ◽  
Luria Bertani ◽  
Major Protein ◽  
Experimental Conditions ◽  
Naturally Occurring ◽  
Standard Procedures ◽  
Test Protein ◽  
Analogous Data

Milkfat globule membranes (MFGMs) were prepared from bovine cream according to standard procedures. These membranes and peptide hydrolysates, which were generated by proteolysis with immobilized digestive enzymes, were screened for antibacterial activity against Escherichia coli O157:H7, Listeria monocytogenes, Salmonella enterica Typhimurium, Pseudomonas fluorescens, Bacillus cereus, Lactobacillus acidophilus, and Lactobacillus gasseri. Assays were first performed on beef heart infusion (BHI) plates spotted with test protein-peptide fractions and then seeded with lawns of indicator cells to monitor the zone of growth inhibition. Under these experimental conditions, MFGMs were most active against Salmonella Typhimurium and P. fluorescens. However, antibacterial activity was not seen after plating on Luria-Bertani (LB) medium. We determined that the antimicrobial effects observed on BHI plates were due to the generation of H2O2 by xanthine oxidase, a major protein constituent of the MFGMs, as a result of purine catalysis. This substrate is present in BHI but lacking in LB medium. Evaluation of purified xanthine oxidase alone resulted in analogous data trends. The growth of probiotic Lactobacillus strains were affected only marginally when grown on lactobacilli deMan Rogosa Sharpe plates, suggesting the decreased sensitivity of these bacteria to H2O2. In this study, several MFGM hydrolysates exhibited variable antibacterial activity against test food pathogens on agar plates prepared with M9 minimal media, and this variation was not attributable to xanthine oxidase enzymatic activity. The probiotic microorganisms were mostly resilient to these antibacterial fractions. Bovine MFGM fractions may represent an excellent resource material from which to generate native, naturally occurring biodefensive proteins and/or peptides.

scholarly journals Antibacterial Activity of Murrayaquinone A and 6-Methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Biswanath Chakraborty ◽  
Suchandra Chakraborty ◽  
Chandan Saha
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Bacillus Subtilis ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Antibacterial Activities ◽  
Gram Positive ◽  
Gram Negative ◽  
Naturally Occurring

The antibacterial activity of Murrayaquinone A (10), a naturally occurring carbazoloquinone alkaloid, and 6-methoxy-3,7-dimethyl-2,3-dihydro-1H-carbazole-1,4(9H)-dione (11), a synthetic carbazoloquinone, both obtained during the development of the synthesis of Carbazomycin G, having unique quinone moiety, was studied against Gram-positive (Bacillus subtilisandStaphylococcus aureus) and Gram-negative (Escherichia coliandPseudomonassp.) bacteria. Compound10showed antibacterial activities against both ofEscherichia coliandStaphylococcus aureuswhereas compound11indicated the activity againstStaphylococcus aureusonly. Both compounds10and11exhibited minimum inhibitory concentration (MIC) of 50 μg mL−1againstStaphylococcus aureus.

The antibacterial activity of some naturally occurring 2,5-dihydroxy-l,4-benzoquinones

1984 ◽  
Vol 30 (8) ◽  
pp. 1068-1072 ◽  
Author(s):  
D. Brewer ◽  
W.-C. Jen ◽  
G. A. Jones ◽  
A. Taylor
Keyword(s):  
Antibacterial Activity ◽  
Related Compound ◽  
Antibiotic Activity ◽  
Number Of Species ◽  
Naturally Occurring ◽  
Metabolic Products

Polyporic acid, atromentin, bovinone, and oosporein are common metabolic products of a number of species of fungi. The related compound cochliodinol and its congeners are produced by several Chaetomium spp. These quinonoid metabolites have been shown to inhibit the growth and metabolism of a range of bacterial genera. The antibiotic activity of the quinones depends on the substituents at the 3 and 6 positions of the 2,5-dihydroxy-1,4-benzoquinone ring; in aerobic systems the activity appears to be inversely proportional to the polarity of the metabolite. It has been shown that reduction of the quinone to the hydroquinone changes the antibiotic activity of these metabolites but does not abolish it. Contrary to previous reports, the activity of these hydroquinones is not reversed by cysteine.

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