scholarly journals The Central Role of Survivin in Proliferation and Apoptosis of Malignant Pleural Mesothelioma

10.5772/32946 ◽  
2012 ◽  
Author(s):  
Julija Hmeljak ◽  
Andrej Cr
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Proliferation And Apoptosis

scholarly journals Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Meilin Chan ◽  
Licun Wu ◽  
Zhihong Yun ◽  
Trevor D. McKee ◽  
Michael Cabanero ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Malignant Pleural Mesothelioma ◽  
Neutralizing Antibodies ◽  
Pleural Mesothelioma ◽  
Spheroid Formation ◽  
Resistance To Therapy ◽  
Sarcomatoid Mesothelioma

AbstractMalignant pleural mesothelioma (MPM) is an aggressive neoplasm originating from the pleura. Non-epithelioid (biphasic and sarcomatoid) MPM are particularly resistant to therapy. We investigated the role of the GITR-GITRL pathway in mediating the resistance to therapy. We found that GITR and GITRL expressions were higher in the sarcomatoid cell line (CRL5946) than in non-sarcomatoid cell lines (CRL5915 and CRL5820), and that cisplatin and Cs-137 irradiation increased GITR and GITRL expressions on tumor cells. Transcriptome analysis demonstrated that the GITR-GITRL pathway was promoting tumor growth and inhibiting cell apoptosis. Furthermore, GITR+ and GITRL+ cells demonstrated increased spheroid formation in vitro and in vivo. Using patient derived xenografts (PDXs), we demonstrated that anti-GITR neutralizing antibodies attenuated tumor growth in sarcomatoid PDX mice. Tumor immunostaining demonstrated higher levels of GITR and GITRL expressions in non-epithelioid compared to epithelioid tumors. Among 73 patients uniformly treated with accelerated radiation therapy followed by surgery, the intensity of GITR expression after radiation negatively correlated with survival in non-epithelioid MPM patients. In conclusion, the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma, associated with tumor stemness and resistance to therapy. Blocking the GITR-GITRL pathway could be a new therapeutic target for non-epithelioid mesothelioma.

The role of imaging in malignant pleural mesothelioma

2002 ◽  
Vol 29 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Edith M. Marom ◽  
Jeremy J. Erasmus ◽  
Harvey I. Pass ◽  
Edward F. Patz
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma

scholarly journals Diagnostic role of immunocytochemistry in malignant pleural mesothelioma

Pathology ◽  
2016 ◽  
Vol 48 ◽  
pp. S136
Author(s):  
Lam Nguyen Son ◽  
Thanh Tran Dinh ◽  
Dung Nguyen Huy
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Diagnostic Role

Abstract 3404: Exploring the role of Twist1 in the pathogenesis of malignant pleural mesothelioma (MPM)

2012 ◽  
Author(s):  
Milind B. Suraokar ◽  
David Kim ◽  
Yi Zhang ◽  
Lixia Diao ◽  
Erick Riquelme ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma

The Role of PET/CT in Staging and Surgical Approach for Malignant Pleural Mesothelioma

CHEST Journal ◽  
2011 ◽  
Vol 140 (4) ◽  
pp. 828A
Author(s):  
Cosimo Lequaglie ◽  
Gabriella Giudice ◽  
Christian Diego Rolfo Cervetto ◽  
Rita Marasco ◽  
Aniello Della Morte
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Surgical Approach ◽  
Pleural Mesothelioma ◽  
Pet Ct

scholarly journals Role of Hedgehog Signaling in Malignant Pleural Mesothelioma

2012 ◽  
Vol 18 (17) ◽  
pp. 4646-4656 ◽  
Author(s):  
Yandong Shi ◽  
Ubiratan Moura ◽  
Isabelle Opitz ◽  
Alex Soltermann ◽  
Hubert Rehrauer ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Hedgehog Signaling ◽  
Pleural Mesothelioma

Prognostic factors in malignant pleural mesothelioma: role of talc pleurodesis

2012 ◽  
Vol 20 (4) ◽  
pp. 443-449 ◽  
Author(s):  
Bassel Suffian Al-Alao ◽  
Haralabos Parissis ◽  
Igor J Rychlik ◽  
Alastair Graham ◽  
Jim McGuigan
Keyword(s):  
Prognostic Factors ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Talc Pleurodesis
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