Central Immune Senescence, Reversal Potentials

Faculty Opinions recommendation of A role for immature myeloid cells in immune senescence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11816956.12922054 ◽

2011 ◽

Author(s):

Berhane Ghebrehiwet ◽

Kinga Hosszu

Keyword(s):

Myeloid Cells ◽

Immune Senescence ◽

Immature Myeloid Cells

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Immune Senescence and Vaccination in the Elderly

Current Topics in Medicinal Chemistry ◽

10.2174/15680266113136660181 ◽

2013 ◽

Vol 13 (20) ◽

pp. 2541-2550 ◽

Cited By ~ 27

Author(s):

Pierre Lang ◽

Sheila Govind ◽

Annemieke Bokum ◽

Natalie Kenny ◽

Emmanuel Matas ◽

...

Keyword(s):

The Elderly ◽

Immune Senescence

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Immune senescence, epigenetics and autoimmunity

Clinical Immunology ◽

10.1016/j.clim.2018.04.002 ◽

2018 ◽

Vol 196 ◽

pp. 59-63 ◽

Cited By ~ 17

Author(s):

Donna Ray ◽

Raymond Yung

Keyword(s):

Immune Senescence

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Immune Senescence: Relative Contributions of Age and Cytomegalovirus Infection

PLoS Pathogens ◽

10.1371/journal.ppat.1002850 ◽

2012 ◽

Vol 8 (8) ◽

pp. e1002850 ◽

Cited By ~ 61

Author(s):

Andrea Mekker ◽

Vincent S. Tchang ◽

Lea Haeberli ◽

Annette Oxenius ◽

Alexandra Trkola ◽

...

Keyword(s):

Cytomegalovirus Infection ◽

Immune Senescence

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Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets

Blood ◽

10.1182/blood-2003-03-0927 ◽

2003 ◽

Vol 102 (9) ◽

pp. 3244-3251 ◽

Cited By ~ 50

Author(s):

Vladimir Janković ◽

Ilhem Messaoudi ◽

Janko Nikolich-Žugich

Keyword(s):

Cell Cycle ◽

T Cell ◽

Replicative Senescence ◽

Rhesus Macaques ◽

T Cell Subsets ◽

Cell Aging ◽

Immune Senescence ◽

Primate Model ◽

In Vitro Proliferation

AbstractA prominent theory of immune senescence holds that repeated antigenic stimulation and decreased production of naive cells combine to progressively exhaust the reserve of lymphocytes available to fight new pathogens, culminating in an accumulation of lymphocytes that achieved replicative senescence. A well-defined primate model of immune senescence in vivo would greatly facilitate testing of this theory. Here, we investigated phenotypic and functional T-cell aging in the rhesus macaques (RMs), currently the dominant primate model of AIDS. Our results show that sharp differences exist between the CD8 and CD4 T-cell subsets in (1) cell-cycle programs (as assessed by both in vitro proliferation and in vivo turnover measurement); (2) CD28 regulation on cell-cycle entry; and (3) accumulation of immediate effector cells among the CD28– cells, believed to be close to or at replicative senescence. These results further suggest poor reliability of CD28 as a marker for senescence. We suggest that some of the T-cell aging phenomenology in RMs can be ascribed to accentuation over time of the inherent differences in activation programs in CD8 and CD4 T cells.

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