scholarly journals Oxidative Stress as a Possible Mechanism of Toxicity of the Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4-D)

10.5772/32524 ◽  
2012 ◽  
Author(s):  
Bettina Bongiovanni ◽  
Cintia Konjuh ◽  
Aristides Pochettino ◽  
Alejandro Ferri
Keyword(s):  
Oxidative Stress ◽  
Dichlorophenoxyacetic Acid ◽  
Mechanism Of Toxicity ◽  
2,4 Dichlorophenoxyacetic Acid

scholarly journals Tolerance of Pseudomonas Strain to the 2,4-D Herbicide through a Peroxidase System

2021 ◽  
Author(s):  
Elizangela Paz Oliveira ◽  
Amanda Flávia da Silva Rovida ◽  
Juliane Gabriele Martins ◽  
Sônia Alvim Veiga Pileggi ◽  
Zelinda Schemczssen-Graeff ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bacterial Communities ◽  
Defense Mechanism ◽  
Agricultural Practices ◽  
Dichlorophenoxyacetic Acid ◽  
Guaiacol Peroxidase ◽  
Pseudomonas Sp ◽  
Nontarget Organisms ◽  
Response System ◽  
2,4 Dichlorophenoxyacetic Acid

Herbicides are widely used in agricultural practices for preventing the proliferation of weeds that compete with crops for survival. Upon reaching soil and water, herbicides can damage nontarget organisms, such as bacteria, which need an efficient defense mechanism to tolerate the stress induced by herbicides. 2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide that exerts increased oxidative stress among bacterial communities that consequently witness an increased toxicity in their microenvironments. Bacterial isolates were obtained from the biofilm of water that was contaminated with 2,4-D. This biofilm originated from the tanks containing washing water from the packaging of different pesticides, including 2,4-D. Moreover, several isolates were sensitive to biofilm toxicity; however, they remained alive in the presence of 2,4-D. The Pseudomonas sp. CMA-7.3 was selected because of its tolerance against biofilm agrochemicals. Therefore, the objective of this study is to evaluate the antioxidative response system of the Pseudomonas sp. CMA-7.3. This study also analyzed poorly evaluated enzymes, such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and guaiacol peroxidase GPX, in the bacterial systems. The toxic effects of 2,4-D on bacteria were evaluated using mechanisms indicating oxidative stress, such as growth curve, cell viability, peroxide, and malondialdehyde. The Pseudomonas sp. CMA-7.3 was an efficient response system against the activity of antioxidant enzymes such as SOD, CAT, APX, and GPX in balancing the production of H 2 O 2 , even at high doses as 25x the field dose of the herbicide, thereby proving the toxicity of 2,4-D for this strain and showing the ability of the strain to tolerate 2,4-D. The adaptation of this microorganism to herbicide exposure is truly relevant for improving future metabolic studies on bacterial communities. The strain showed a great potential in the application and developmental prospects of a new product in the bioremediation process of environments contaminated by these herbicides.

Oxidative stress and metabolic perturbations in Escherichia coli exposed to sublethal levels of 2,4-dichlorophenoxyacetic acid

Chemosphere ◽  
2015 ◽  
Vol 135 ◽  
pp. 453-461 ◽  
Author(s):  
Supriya V. Bhat ◽  
Sean C. Booth ◽  
Erik A.N. Vantomme ◽  
Shirin Afroj ◽  
Christopher K. Yost ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Escherichia Coli ◽  
Dichlorophenoxyacetic Acid ◽  
2,4 Dichlorophenoxyacetic Acid

Trichoderma harzianum diminished oxidative stress caused by 2,4- dichlorophenoxyacetic acid (2,4-D) in wheat, with insights from lipidomics

2018 ◽  
Vol 229 ◽  
pp. 158-163 ◽  
Author(s):  
Przemysław Bernat ◽  
Justyna Nykiel-Szymańska ◽  
Ewa Gajewska ◽  
Sylwia Różalska ◽  
Paulina Stolarek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trichoderma Harzianum ◽  
Dichlorophenoxyacetic Acid ◽  
2,4 Dichlorophenoxyacetic Acid

2,4-D exposure and urinary markers of oxidative DNA damage and lipid peroxidation: a longitudinal study

2020 ◽  
Vol 77 (4) ◽  
pp. 276-280 ◽  
Author(s):  
Catherine Chase Lerro ◽  
Gabriella Andreotti ◽  
Jason YY Wong ◽  
Aaron Blair ◽  
Nathaniel Rothman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Dna Damage ◽  
Laboratory Animals ◽  
Dichlorophenoxyacetic Acid ◽  
Mixed Effect ◽  
Prostaglandin F ◽  
Markers Of Oxidative Stress ◽  
2,4 Dichlorophenoxyacetic Acid ◽  
Longitudinal Biomarker ◽  
Future Work

Objective2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide that is commonly used commercially, agriculturally and residentially worldwide. There is concern about its potential for carcinogenicity based on studies in laboratory animals demonstrating the potential for induction of oxidative stress. We conducted a longitudinal biomarker study of 31 pesticide applicators in Kansas who heavily applied 2,4-D and 34 non-applicator controls.MethodsWe used multivariable generalised linear mixed-effect models to evaluate the association between urinary 2,4-D and natural log-transformed 8-iso prostaglandin F2α (8-isoprostane) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), adjusting for urinary creatinine, age, tobacco use and concomitant use of the herbicide picloram.ResultsCompared with non-applicator controls, urinary 2,4-D in the third quartile of exposure was associated with elevated 8-isoprostane (eβ=1.38, 95% CI 1.03 to 1.84). There was no association among the highest exposed and no exposure-response trend. 2,4-D exposure was not associated with 8-OHdG. Results were unchanged when restricted to participants who only applied 2,4-D (no picloram use).ConclusionsWe did not find evidence that increasing 2,4-D exposure was associated with 8-isoprostane or 8-OHdG. Future work should carefully evaluate potential confounders of this association, such as diet and physical activity, as well as additional biological markers of oxidative stress and damage.

Melatonin decreases the oxidative stress produced by 2,4-dichlorophenoxyacetic acid in rat cerebellar granule cells

2007 ◽  
Vol 11 (2) ◽  
pp. 93-99 ◽  
Author(s):  
B. Bongiovanni ◽  
P. De Lorenzi ◽  
A. Ferri ◽  
C. Konjuh ◽  
M. Rassetto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Dichlorophenoxyacetic Acid ◽  
Cerebellar Granule ◽  
2,4 Dichlorophenoxyacetic Acid
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