scholarly journals Different Faces of Chronic Autoimmune Thyroiditis in Childhood and Adolescence

10.5772/32366 ◽  
2012 ◽  
Author(s):  
Ljiljana Saranac ◽  
Hristina Stamenkovic
Keyword(s):  
Autoimmune Thyroiditis ◽  
Childhood And Adolescence ◽  
Chronic Autoimmune Thyroiditis

scholarly journals THE EXPERIENCE OF APPLICATION OF COMPLEX FITODRUG CONTAINING POTENTILLA ALBA L. IN PATIENTS WITH CHRONIC AUTOIMMUNE THYROIDITIS

2020 ◽  
Vol 4 (2) ◽  
pp. 83
Author(s):  
M. J. Hotsko ◽  
V. O. Serhiyenko ◽  
I. V. Bobrovych ◽  
R. J. Makarovska ◽  
O. O. Serhiyenko
Keyword(s):  
Autoimmune Thyroiditis ◽  
Chronic Autoimmune Thyroiditis

Expression of TIGIT and FCRL3 is Altered in T Cells from Patients with Distinct Patterns of Chronic Autoimmune Thyroiditis

2018 ◽  
Vol 127 (05) ◽  
pp. 281-288 ◽  
Author(s):  
Mario Štefanić ◽  
Stana Tokić ◽  
Mirjana Suver-Stević ◽  
Ljubica Glavaš-Obrovac
Keyword(s):  
T Cells ◽  
Autoimmune Thyroiditis ◽  
Thyroid Volume ◽  
Thyroid Peroxidase ◽  
Mrna Levels ◽  
Expression Levels ◽  
Chronic Autoimmune Thyroiditis ◽  
End Stage ◽  
Hypothyroid Patients

Abstract Background Co-inhibitory receptors (IR), such as TIGIT and FCRL3, provide a checkpoint against highly destructive immune responses. Co-expression of TIGIT and FCRL3, in particular, has been linked to the HELIOS+ subset of regulatory CD4+FOXP3+T-cells. Of these, CD4+FOXP3-exon(E)2+ cells have higher expression of IR and exhibit strongest suppressive properties. Nevertheless, how the expression of TIGIT, FCRL3, HELIOS, and FOXP3E2 is regulated in chronic autoimmune thyroiditis (AT), is not known. Methods Thirty patients with AT [encompassing spontaneously euthyroid (euAT), hypothyroid-untreated and L-thyroxine-treated cases)] and 10 healthy controls (HC) were recruited. FCRL3, TIGIT, HELIOS and FOXP3E2 mRNA expression levels in peripheral blood (PB) T cells were measured via quantitative real-time PCR and compared to clinicopathological factors. Results The TIGIT and FCRL3 expression levels from T cells of AT cases were inversely related to the thyroid volume, and were significantly increased in hypothyroid patients (on+off L-thyroxine), but not euAT cases. The FCRL3 expression in PB T cells positively correlated with thyroid-peroxidase autoantibody levels; by contrast, T cells from aged AT patients and combined samples (AT+HC) accumulated more TIGIT mRNA. The patients with higher TIGIT mRNA levels had a greater prevalence of hypothyroidism, showing higher peak thyrotropin levels at diagnosis or at follow-up. Conclusions Multiple IR, namely FCRL3 and TIGIT, but not the transcription factors HELIOS and FOXP3E2, showed increased mRNA levels in PB T cells from end-stage, long-standing and/or more aggressive AT, in proportion to disease severity. A relation with major clinical subphenotypes was observed, thereby identifying IR as potentially important players in AT.

Chronic Autoimmune Thyroiditis

2019 ◽  
pp. 379-397
Author(s):  
Andrea Carbone ◽  
Mario Rotondi ◽  
Luca Chiovato
Keyword(s):  
Autoimmune Thyroiditis ◽  
Chronic Autoimmune Thyroiditis

Is chronic autoimmune thyroiditis a systemic disease?

2003 ◽  
Vol 115 (5) ◽  
pp. 412-413 ◽  
Author(s):  
Gherardo Mazziotti ◽  
Giovanni Amato ◽  
Carlo Carella
Keyword(s):  
Autoimmune Thyroiditis ◽  
Systemic Disease ◽  
Chronic Autoimmune Thyroiditis
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