Distraction Osteogenesis and Its Challenges in Bone Regeneration

10.5772/32229 ◽  
2012 ◽  
Author(s):  
Reggie C. ◽  
Juan S. ◽  
Maryam Tabrizi
Keyword(s):  
Bone Regeneration ◽  
Distraction Osteogenesis

scholarly journals Systemic Administration of G-CSF Accelerates Bone Regeneration and Modulates Mobilization of Progenitor Cells in a Rat Model of Distraction Osteogenesis

2021 ◽  
Vol 22 (7) ◽  
pp. 3505
Author(s):  
Flavy Roseren ◽  
Martine Pithioux ◽  
Stéphane Robert ◽  
Laure Balasse ◽  
Benjamin Guillet ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Progenitor Cells ◽  
Distraction Osteogenesis ◽  
Rat Model ◽  
Late Phase ◽  
Control Group ◽  
Bone Lengthening ◽  
Hematopoietic Stem ◽  
Osteoblast Activity ◽  
Positron Emission

Granulocyte colony-stimulating factor (G-CSF) was shown to promote bone regeneration and mobilization of vascular and osteogenic progenitor cells. In this study, we investigated the effects of a systemic low dose of G-CSF on both bone consolidation and mobilization of hematopoietic stem/progenitor cells (HSPCs), endothelial progenitor cells (EPCs) and mesenchymal stromal cells (MSCs) in a rat model of distraction osteogenesis (DO). Neovascularization and mineralization were longitudinally monitored using positron emission tomography and planar scintigraphy. Histological analysis was performed and the number of circulating HSPCs, EPCs and MSCs was studied by flow cytometry. Contrary to control group, in the early phase of consolidation, a bony bridge with lower osteoclast activity and a trend of an increase in osteoblast activity were observed in the distracted callus in the G-CSF group, whereas, at the late phase of consolidation, a significantly lower neovascularization was observed. While no difference was observed in the number of circulating EPCs between control and G-CSF groups, the number of MSCs was significantly lower at the end of the latency phase and that of HSPCs was significantly higher 4 days after the bone lengthening. Our results indicate that G-CSF accelerates bone regeneration and modulates mobilization of progenitor cells during DO.

scholarly journals Bone Regeneration in Distraction Osteogenesis Demonstrates Significantly Increased Vascularity in Comparison to Fracture Repair in the Mandible

2012 ◽  
Vol 23 (1) ◽  
pp. 328-332 ◽  
Author(s):  
Alexis Donneys ◽  
Catherine N. Tchanque-Fossuo ◽  
Aaron S. Farberg ◽  
Sagar S. Deshpande ◽  
Steven R. Buchman
Keyword(s):  
Bone Regeneration ◽  
Distraction Osteogenesis ◽  
Fracture Repair

scholarly journals Deferoxamine Enhances the Vascular Response of Bone Regeneration in Mandibular Distraction Osteogenesis

2012 ◽  
Vol 129 (4) ◽  
pp. 850-856 ◽  
Author(s):  
Alexis Donneys ◽  
Aaron S. Farberg ◽  
Catherine N. Tchanque-Fossuo ◽  
Sagar S. Deshpande ◽  
Steven R. Buchman
Keyword(s):  
Bone Regeneration ◽  
Distraction Osteogenesis ◽  
Vascular Response ◽  
Mandibular Distraction ◽  
Mandibular Distraction Osteogenesis

Bone Regeneration in Mandibular Distraction Osteogenesis Combined With Compression Stimulation

2006 ◽  
Vol 64 (10) ◽  
pp. 1498-1505 ◽  
Author(s):  
Uk-Kyu Kim ◽  
In-Kyo Chung ◽  
Kwang-Ho Lee ◽  
James Q. Swift ◽  
Wook-Jin Seong ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Distraction Osteogenesis ◽  
Mandibular Distraction ◽  
Mandibular Distraction Osteogenesis

Comparison of Canine Mandibular Bone Regeneration by Distraction Osteogenesis versus Acute Resection and Rigid External Fixation

2004 ◽  
pp. 1490-1499 ◽  
Author(s):  
Arun K. Gosain ◽  
Behrooz Kalantarian ◽  
Lian Shen Song ◽  
Jeffrey D. Larson ◽  
Christopher A. Jenkins ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
External Fixation ◽  
Distraction Osteogenesis ◽  
Mandibular Bone
Sign in / Sign up

Export Citation Format

Share Document