scholarly journals Electrical Neuromodulation and the Heart with Special Emphasis on Myocardial Ischemia

10.5772/32007 ◽  
2012 ◽  
Author(s):  
Mike J.L.
Keyword(s):  
Myocardial Ischemia ◽  
Electrical Neuromodulation

scholarly journals Dorsal spinal cord stimulation obtunds the capacity of intrathoracic extracardiac neurons to transduce myocardial ischemia

2009 ◽  
Vol 297 (2) ◽  
pp. R470-R477 ◽  
Author(s):  
Jeffrey L. Ardell ◽  
René Cardinal ◽  
Michel Vermeulen ◽  
J. Andrew Armour
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Myocardial Ischemia ◽  
Spinal Cord Stimulation ◽  
Ventricular Pacing ◽  
Cervical Ganglion ◽  
Rapid Ventricular Pacing ◽  
Local Reflex ◽  
Electrical Neuromodulation ◽  
Ganglion Neurons

Populations of intrathoracic extracardiac neurons transduce myocardial ischemia, thereby contributing to sympathetic control of regional cardiac indices during such pathology. Our objective was to determine whether electrical neuromodulation using spinal cord stimulation (SCS) modulates such local reflex control. In 10 anesthetized canines, middle cervical ganglion neurons were identified that transduce the ventricular milieu. Their capacity to transduce a global (rapid ventricular pacing) vs. regional (transient regional ischemia) ventricular stress was tested before and during SCS (50 Hz, 0.2 ms duration at 90% MT) applied to the dorsal aspect of the T1 to T4 spinal cord. Rapid ventricular pacing and transient myocardial ischemia both activated cardiac-related middle cervical ganglion neurons. SCS obtunded their capacity to reflexly respond to the regional ventricular ischemia, but not rapid ventricular pacing. In conclusion, spinal cord inputs to the intrathoracic extracardiac nervous system obtund the latter's capacity to transduce regional ventricular ischemia, but not global cardiac stress. Given the substantial body of literature indicating the adverse consequences of excessive adrenergic neuronal excitation on cardiac function, these data delineate the intrathoracic extracardiac nervous system as a potential target for neuromodulation therapy in minimizing such effects.

Evaluation of myocardial ischemia during beating-heart aortic arch repair in a piglet model

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
A Rüffer ◽  
S Kellermann ◽  
C Janssen ◽  
F Münch ◽  
M Demuth ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Aortic Arch ◽  
Beating Heart ◽  
Aortic Arch Repair
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