scholarly journals Antidepressant Pharmacotherapy – Do the Benefits Outweigh the Risks?

10.5772/31962 ◽  
2012 ◽  
Author(s):  
Angela Getz ◽  
Fenglian Xu ◽  
Naweed Sye
Keyword(s):  
Antidepressant Pharmacotherapy

Therapy of post-stroke depression – a systematic review

2013 ◽  
Vol 10 (02) ◽  
pp. 108-129 ◽  
Author(s):  
W. Gaebel ◽  
W. Wannagat ◽  
J. Zielasek
Keyword(s):  
Systematic Review ◽  
Large Scale ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Placebo Control ◽  
Post Stroke ◽  
Pharmacological Studies ◽  
Post Stroke Depression ◽  
Control Procedures ◽  
Antidepressant Pharmacotherapy

SummaryWe performed a systematic review of randomized placebo-controlled pharmacological and non-pharmacological trials for the therapy and prevention of post-stroke depression that have been published between 1980 and 2011. We initially identified 2 260 records of which 28 studies were finally included into this review. A meta-analytic approach was hampered by considerable differences regarding the kinds of therapeutic regimens and the study durations. Modest effects favoring treatment of post-stroke depression could be found for pharmacological treatment as well as repetitive transcranial magnetic stimulation. For the prevention of post-stroke depression, antidepressant pharmacotherapy showed promising results. However, large-scale studies with better standardized study populations, optimized placebo control procedures in non-pharmacological studies, and replication in larger follow-up studies are still necessary to find the optimal therapeutic regimens to prevent and treat post-stroke depression.

scholarly journals Alterations in BDNF Protein Concentrations in the Hippocampus do not Explain the Pro-Neurogenic Effect of Citalopram on Adult Neurogenesis

2020 ◽  
Author(s):  
Markus Petermann ◽  
Golo Kronenberg ◽  
Valentina Mosienko ◽  
Michael Bader ◽  
Natalia Alenina ◽  
...  
Keyword(s):  
Cell Survival ◽  
Mechanism Of Action ◽  
Adult Neurogenesis ◽  
Neurotrophic Factor ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Daily Injection ◽  
Wild Type ◽  
Protein Levels ◽  
Serotonin System ◽  
Antidepressant Pharmacotherapy

Abstract Introduction Brain-derived neurotrophic factor (BDNF) has been implicated in the pro-neurogenic effect of selective serotonin reuptake inhibitors. In this study, we used Tph2 −/− mice lacking brain serotonin to dissect the interplay between BDNF and the serotonin system in mediating the effects of antidepressant pharmacotherapy on adult neurogenesis in the hippocampus. Methods Besides citalopram (CIT), we tested tianeptine (TIA), an antidepressant whose mechanism of action is not well understood. Specifically, we examined cell survival and endogenous concentrations of BDNF following daily injection of the drugs. Results Twenty-one days of CIT, but not of TIA, led to a significant increase in the survival of newly generated cells in the dentate gyrus of wild-type mice, without a significant effect on BDNF protein levels by either treatment. In Tph2 −/− mice, adult neurogenesis was consistently increased. Furthermore, Tph2 −/− mice showed increased BDNF protein levels, which were not affected by TIA but were significantly reduced by CIT. Discussion We conclude that the effects of CIT on adult neurogenesis are not explained by changes in BDNF protein concentrations in the hippocampus.

Recovery From Major Depression in Older Adults Receiving Augmentation of Antidepressant Pharmacotherapy

2007 ◽  
Vol 164 (6) ◽  
pp. 892-899 ◽  
Author(s):  
Mary Amanda Dew ◽  
Ellen M. Whyte ◽  
Eric J. Lenze ◽  
Patricia R. Houck ◽  
Benoit H. Mulsant ◽  
...  
Keyword(s):  
Older Adults ◽  
Major Depression ◽  
Antidepressant Pharmacotherapy

Ethnicity and the Prescribing of Antidepressant Pharmacotherapy: 1992-1995

1999 ◽  
Vol 7 (1) ◽  
pp. 29-36 ◽  
Author(s):  
David A. Sclar ◽  
Linda M. Robison ◽  
Tracy L. Skaer ◽  
Richard S. Galin
Keyword(s):  
Antidepressant Pharmacotherapy

REM density is associated with treatment response in major depression: Antidepressant pharmacotherapy vs. psychotherapy

2021 ◽  
Vol 133 ◽  
pp. 67-72
Author(s):  
Julia Lechinger ◽  
Jakob Koch ◽  
Sara Lena Weinhold ◽  
Mareen Seeck-Hirschner ◽  
Karoline Stingele ◽  
...  
Keyword(s):  
Major Depression ◽  
Treatment Response ◽  
Rem Density ◽  
Antidepressant Pharmacotherapy

Isotretinoin and antidepressant pharmacotherapy: A prescription sequence symmetry analysis

2003 ◽  
Vol 49 (3) ◽  
pp. 424-432 ◽  
Author(s):  
Kimberly Hersom ◽  
Maureen P Neary ◽  
Hugh P Levaux ◽  
Winslow Klaskala ◽  
John S Strauss
Keyword(s):  
Symmetry Analysis ◽  
Antidepressant Pharmacotherapy
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