scholarly journals Plant Ageing, a Counteracting Agent to Xenobiotic Stress

Senescence ◽  
10.5772/31944 ◽  
2012 ◽  
Author(s):  
David Delmail ◽  
Pascal Labrousse
Keyword(s):  
Xenobiotic Stress ◽  
Plant Ageing

scholarly journals Molecular Forces Governing the Biological Function of Per-Arnt-Sim-B (PAS-B) Domains: A Comparative Computational Study

Biophysica ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 1-14
Author(s):  
João Victor de Souza ◽  
Piotr Zaborniak ◽  
Sylvia Reznikov ◽  
Matthew Kondal ◽  
Ruidi Zhu ◽  
...  
Keyword(s):  
Juvenile Hormone ◽  
Hormone Receptor ◽  
Redox Regulation ◽  
Biological Function ◽  
Computational Study ◽  
Sequence Similarity ◽  
Molecular Characteristics ◽  
Drosophila Suzukii ◽  
Xenobiotic Stress ◽  
Molecular Features

Per-Arnt-Sim (PAS) domains are evolutionarily-conserved regions found in proteins in all living systems, involved in transcriptional regulation and the response to hypoxic and xenobiotic stress. Despite having low primary sequence similarity, they show an impressively high structural conservation. Nonetheless, understanding the underlying mechanisms that drive the biological function of the PAS domains remains elusive. In this work, we used molecular dynamics simulations and bioinformatics tools in order the investigate the molecular characteristics that govern the intrinsic dynamics of five PAS-B domains (human AhR receptor, NCOA1, HIF1α, and HIF2α transcription factors, and Drosophila Suzukii (D. Suzukii) juvenile hormone receptor JHR). First, we investigated the effects of different length of N and C terminal regions of the AhR PAS-B domain, showing that truncation of those segments directly affects structural stability and aggregation propensity of the domain. Secondly, using the recently annotated PAS-B located in the methoprene-tolerant protein/juvenile hormone receptor (JHR) from D. Suzukii, we have shown that the mutation of the highly conserved “gatekeeper” tyrosine to phenylalanine (Y322F) does not affect the stability of the domain. Finally, we investigated possible redox-regulation of the AhR PAS-B domain by focusing on the cysteinome residues within PAS-B domains. The cysteines in AhR PAS-B are directly regulating the dynamics of the small molecule ligand-gating loop (residues 305 to 326). In conclusion, we comprehensibly described several molecular features governing the behaviour of PAS-B domains in solution, which may lead to a better understanding of the forces driving their biological functions.

BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity

2007 ◽  
Vol 62 (4) ◽  
pp. 689-697 ◽  
Author(s):  
Hyo Jin Kang ◽  
Hee Jeong Kim ◽  
Sang Hoon Kwon ◽  
Brian DongHoon Kang ◽  
Thomas E. Eling ◽  
...  
Keyword(s):  
Erod Activity ◽  
Xenobiotic Stress ◽  
Protein Levels ◽  
Inducible Protein

scholarly journals Xenobiotic Stress Induces Hepatomegaly and Liver Tumors via the Nuclear Receptor Constitutive Androstane Receptor

2005 ◽  
Vol 19 (6) ◽  
pp. 1646-1653 ◽  
Author(s):  
Wendong Huang ◽  
Jun Zhang ◽  
Michele Washington ◽  
Jun Liu ◽  
John M. Parant ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Liver Tumors ◽  
Constitutive Androstane Receptor ◽  
Xenobiotic Stress

scholarly journals Dopamine signaling promotes the xenobiotic stress response and protein homeostasis

2016 ◽  
Vol 35 (17) ◽  
pp. 1885-1901 ◽  
Author(s):  
Kishore K Joshi ◽  
Tarmie L Matlack ◽  
Christopher Rongo
Keyword(s):  
Stress Response ◽  
Protein Homeostasis ◽  
Xenobiotic Stress ◽  
Dopamine Signaling

scholarly journals In vivo target promoter-binding activities of a xenobiotic stress-activated TGA factor

2001 ◽  
Vol 28 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Christopher Johnson ◽  
Erin Boden ◽  
Mihir Desai ◽  
Pete Pascuzzi ◽  
Jonathan Arias
Keyword(s):  
Xenobiotic Stress ◽  
Target Promoter

Catalysts Deactivation: Pilot plant ageing tests and correlation with industrial data

1991 ◽  
Vol 11 (1) ◽  
pp. 93-101 ◽  
Author(s):  
P. Sarrazin ◽  
J.P. Boitiaux ◽  
M. Berthelin ◽  
J.C. Plumail
Keyword(s):  
Pilot Plant ◽  
Industrial Data ◽  
Plant Ageing

scholarly journals NHR-8 regulated P-glycoproteins uncouple xenobiotic stress resistance from longevity in chemosensory C. elegans mutants

2019 ◽  
Author(s):  
Gabriel A. Guerrero ◽  
Matías D. Hartman ◽  
Klara Schilling ◽  
Felix A.M.C. Mayr ◽  
Ryan Lu ◽  
...  
Keyword(s):  
Stress Resistance ◽  
Intraflagellar Transport ◽  
Pathogen Resistance ◽  
Nuclear Hormone Receptor ◽  
P38 Map Kinase ◽  
Xenobiotic Stress ◽  
C Elegans ◽  
Xenobiotic Detoxification ◽  
A Cell ◽  
Necessary And Sufficient

AbstractLongevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory defective Caenorhabditis elegans mutants that are long-lived and stress resistant. We find that mutants in the intraflagellar transport protein gene osm-3 were significantly protected from tunicamycin-induced ER stress. While osm-3 lifespan extension is dependent on the key longevity factor DAF-16/FOXO, tunicamycin resistance was not. osm-3 mutants are protected from bacterial pathogens, which is pmk-1 p38 MAP kinase dependent while TM resistance was pmk-1 independent. Inhibition of P-glycoproteins with verapamil suppressed tunicamycin resistance and expression of P-glycoprotein xenobiotic detoxification genes was elevated in osm-3 mutants. The nuclear hormone receptor nhr-8 was necessary and sufficient to regulate P-glycoproteins and tunicamycin resistance in a cholesterol-dependent fashion. We thus identify a cell-nonautonomous regulation of xenobiotic detoxification and show that separate pathways are engaged to mediate longevity, pathogen resistance, and xenobiotic detoxification in osm-3 mutants.

scholarly journals Increase in longevity and amelioration of pesticide toxicity by natural levels of dietary phytochemicals in the honey bee, Apis mellifera

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243364
Author(s):  
Ling-Hsiu Liao ◽  
Daniel J. Pearlstein ◽  
Wen-Yen Wu ◽  
Allison G. Kelley ◽  
William M. Montag ◽  
...  
Keyword(s):  
Honey Bees ◽  
Central Valley ◽  
Pollination Services ◽  
Colony Losses ◽  
Xenobiotic Stress ◽  
Almond Trees ◽  
Natural Range ◽  
Natural Foods ◽  
Open Question ◽  
Phytochemical Components

For the past decade, migratory beekeepers who provide honey bees for pollination services have experienced substantial colony losses on a recurring basis that have been attributed in part to exposure to insecticides, fungicides, or their combinations applied to crops. The phytochemicals p-coumaric acid and quercetin, which occur naturally in a wide variety of bee foods, including beebread and many types of honey, can enhance adult bee longevity and reduce the toxicity of certain pesticides. How variation in concentrations of natural dietary constituents affects interactions with xenobiotics, including synthetic pesticides, encountered in agroecosystems remains an open question. We tested the effects of these two phytochemicals at a range of natural concentrations on impacts of consuming propiconazole and chlorantraniliprole, a triazole fungicide and an insecticide frequently applied as a tank mix to almond trees during bloom in California’s Central Valley. Propiconazole, even at low field concentrations, significantly reduced survival and longevity when consumed by adult bees in a sugar-based diet. The effects of propiconazole in combination with chlorantraniliprole enhanced mortality risk. The detrimental effects of the two pesticides were for the most part reduced when either or both of the phytochemicals were present in the diet. These findings suggest that honey bees may depend on non-nutritive but physiologically active phytochemical components of their natural foods for ameliorating xenobiotic stress, although only over a certain range of concentrations; particularly at the high end of the natural range, certain combinations can incur additive toxicity. Thus, efforts to develop nectar or pollen substitutes with phytochemicals to boost insecticide tolerance or immunity or to evaluate toxicity of pesticides to pollinators should take concentration-dependent effects of phytochemicals into consideration.

scholarly journals OZONE THERAPY: MECHANISMS OF ACTION, RECENT LITERATURE AND NEWLY DISCOVERED BIOCHEMICAL PATHWAYS

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Lamberto Re
Keyword(s):  
Mitochondrial Respiratory Chain ◽  
Complementary Therapy ◽  
Pharmacological Action ◽  
Cellular Level ◽  
Point Of View ◽  
Ozone Therapy ◽  
Xenobiotic Stress ◽  
Biochemical Pathways ◽  
Endogenous Antioxidant

Ozone therapy is widely used in many countries since many years. Recently, the increasing widespread of this complementary therapy has been accomplished by an increased number of basic and clinic papers published on international journals. This lecture will deal on the first approach by a pharmacological point of view in the aim to characterize the mechanisms activated at sub-cellular level by ozone when used for medical and beauty application at low graded doses. The first theory was based upon the fact that the exposure to low, non-toxic, ozone concentrations could increase the efficacy of the endogenous antioxidant system by increasing the production or the activity of some enzymes exerting a key role in the mitochondrial respiratory chain. Many of the basic mechanisms of the ozone action are now well outlined. In addition, the modulation of interleukins productions and of some biochemical pathways related to inflammation and pain, indicates the rationale of its use in many pathological conditions related to pain, inflammation and age disorders. We also discuss on the mode of action of ozone that, with an hormetic mechanism, appear to be more similar to xenobiotic stress model than a pure pharmacological action. Indeed, our recent work in vivo on patients treated with major autohemo therapy (MAH) demonstrated the increase of Nrf2 level (P

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