Central Nervous System Vascular Malformations

Congenital malformations of the central nervous system (CNS) are among the most common anomalies, but data on the incidence of CNS malformations in autopsy populations are scant. We examined 4122 autopsies between the years 1958 and 1995. There were 363 cases (8.8%) with CNS malformations; 235 were neonates and 128 stillborns. The overall gender ratio was 1:1, although more male neonates and more female stillborns had malformations. The body weights ranged from 24 to 6440 g. Neural tube defects were the most common types of malformations (45.5%) and included anencephaly, meningoencephalocele, meningocele/meningomyelocele, craniospinal rachischisis, and spina bifida occulta. The incidences of other malformations were: congenital hydrocephalus (12.4%), neuronal/glial proliferation disorders such as micro- and macrocephaly (8.8%), neuronal migration disorders (8.8%), prosencephalon growth disorders such as holoprosencephaly and arhinencephaly (8.5%), abnormalities of the midline structures such as agenesis of corpus callosum (4.1%), developmental cysts (3.3%), cerebellar malformations (3%), and vascular malformations (2%). Miscellaneous malformations (3%) consisted of acephalia in four cases with twin reversed arterial perfusion (TRAP), two cases of hydranencephaly, and four cases of rare degenerative and metabolic encephalopathies.

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Quality of life in patients with vascular malformations outside the central nervous system: Comparison with the general Norwegian population

Journal of Plastic Reconstructive & Aesthetic Surgery ◽

10.1016/j.bjps.2019.09.024 ◽

2019 ◽

Vol 72 (12) ◽

pp. 1880-1886

Author(s):

Sigurd Berger ◽

Rune Andersen ◽

Eric Dorenberg ◽

Tone Meyer ◽

Inanna Weiss ◽

...

Keyword(s):

Quality Of Life ◽

Central Nervous System ◽

Nervous System ◽

Vascular Malformations ◽

Norwegian Population ◽

The Central Nervous System

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Expression of Angiogenic Factors and Structural Proteins in Central Nervous System Vascular Malformations

Neurosurgery ◽

10.1097/00006123-199605000-00011 ◽

1996 ◽

Vol 38 (5) ◽

pp. 915-925 ◽

Cited By ~ 164

Author(s):

David Rothbart ◽

Issam A. Awad ◽

Jiyon Lee ◽

Jung Kim ◽

Robert Harbaugh ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Vascular Malformations ◽

Angiogenic Factors ◽

Structural Proteins

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“Cryptic” Vascular Malformations of the Central Nervous System

Journal of Neurosurgery ◽

10.3171/jns.1966.24.5.0865 ◽

1966 ◽

Vol 24 (5) ◽

pp. 865-875 ◽

Cited By ~ 176

Author(s):

William F. McCormick ◽

John D. Nofzinger

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Vascular Malformations ◽

The Central Nervous System

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Vascular malformations of central nervous system: A series from tertiary care hospital in South India

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.176196 ◽

2016 ◽

Vol 07 (02) ◽

pp. 262-268

Author(s):

Sudhir Babu Karri ◽

Megha S. Uppin ◽

A. Rajesh ◽

K. Ashish ◽

Suchanda Bhattacharjee ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Vascular Malformations ◽

Demographic Data ◽

Periodic Acid ◽

Tertiary Care ◽

Care Hospital ◽

Periodic Acid Schiff ◽

Radiological Features ◽

Risk Of Hemorrhage

ABSTRACT Aims and Objectives: To describe clinicopathological features of surgically resected vascular malformations (VMs) of central nervous system (CNS). Materials and Methods: Histologically diagnosed cases of VMs of CNS during April 2010–April 2014 were included. Demographic data, clinical and radiological features were obtained. Hematoxylin and eosin slides were reviewed along with Verhoeff-Van Gieson (VVG), Masson’s trichrome, periodic acid-Schiff, and Perls’ stains. Morphologically, cavernomas and arteriovenous malformations (AVMs) were distinguished on the basis of vessel wall features on VVG and intervening glial parenchyma. Results: Fifty cases were diagnosed as VMs of CNS with an age range of 14–62 years. These included 36 cavernomas, 12 AVMs, 2 mixed capillary-cavernous angiomas. Most of the cavernoma patients (15/36) presented with seizures, whereas AVM patients (8/12) had a headache as the dominant symptom. Twenty-nine patients were reliably diagnosed on radiological features. Microscopic evidence of hemorrhage was seen in 24/36 cavernomas and 6/12 AVMs, as opposed to radiologic evidence of 10 and 4, respectively. Reactive gliosis was seen in 16 cavernomas. Conclusions: Histological features are important for classifying the VMs of CNS as there are no specific clinical and radiological features. Type of VM has a bearing on management, prognosis, and risk of hemorrhage.

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