scholarly journals Genomic Microarray Quality Assurance

10.5772/31603 ◽  
2011 ◽  
Author(s):  
Catherine D. ◽  
Lisa G. ◽  
Kyle S.
Keyword(s):  
Quality Assurance ◽  
Genomic Microarray

Technical Standards and Guidelines for Use of Clinical Genomic Microarray Analysis in Hematopoietic and Other Neoplastic Disorders: A Draft From a Working Group of the American College of Medical Genetics Laboratory Quality Assurance Committee

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4906-4906
Author(s):  
Marilyn L Slovak ◽  
Daynna J Wolff ◽  
Marilyn M Li ◽  
Matthew S Lebo ◽  
Linda D Cooley
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Working Group ◽  
Copy Number ◽  
Clinical Laboratory ◽  
Medical Genetics ◽  
Technical Standards ◽  
Quality Control Metrics ◽  
Standards And Guidelines ◽  
Genomic Microarray

Abstract Abstract 4906 Interrogation of the genome utilizing microarray technologies (copy number array-CGH with or without single-nucleotide polymorphism (SNP) probes) allows detection of genomic gains and losses with unprecedented resolution. Array findings are increasing our knowledge of the genetic basis of hematologic and other malignancies. However, prior to the clinical use of these new analytic tools, laboratories must extensively validate multiple parameters such as their platform(s), software, methods, detection limits, and quality control metrics. The laboratory must demonstrate expertise in the performance of the test and interpretation of the results by testing numerous samples, different sample types, and samples from patients with different types of diseases; these array results should then be compared with the results obtained using the gold standard methods. A working group of the Laboratory Quality Assurance committee of the American College of Medical Genetics (ACMG), a professional organization of board-certified clinical and laboratory geneticists, has drafted technical standards and guidelines for clinical laboratories that intend to offer clinical testing using these technologies. The ACMG Technical Standards and Guidelines provide support for clinical laboratory geneticists to help them provide quality laboratory genetic services. The guidelines discuss array design, selection and coverage of the genomic microarray platforms, manufacturer's premarket analytical validation recommendations (assay performance characteristics, quality parameters, and software specifications), laboratory validation recommendations for each neoplastic disorder and tissue type (blood, bone marrow, and formalin-fixed paraffin-embedded tissue), quality control metrics and documentation, and methods for confirmation of the copy number aberrations (e.g., conventional cytogenetics, FISH, PCR, MLPA, or a different microarray). Data analysis, interpretation and reporting recommendations relating to clonal diversity, limitations of the assay, and the assessment of the clinical significance of array findings are included. Quality assurance guidelines address laboratory personnel training and certification, proficiency testing, and clinically appropriate turnaround times. Clinical laboratory medical professionals with appropriate training and certification will correlate clinical and pathological information with array findings for final reporting. The ACMG Laboratory QA committee welcomes input as the draft guidelines are being formulated. Disclosures: No relevant conflicts of interest to declare.

Outcomes/Quality Assurance

1999 ◽  
Vol 8 (1) ◽  
pp. 15-17
Author(s):  
Michael Groher ◽  
Caryn Easterling
Keyword(s):  
Quality Assurance

Percutaneous Tracheostomy: A Multidisciplinary Approach

2008 ◽  
Vol 18 (2) ◽  
pp. 87-98 ◽  
Author(s):  
Vinciya Pandian ◽  
Thai Tran Nguyen ◽  
Marek Mirski ◽  
Nasir Islam Bhatti
Keyword(s):  
Health Care ◽  
Quality Assurance ◽  
Data Collection ◽  
Health Care Professionals ◽  
Multidisciplinary Approach ◽  
Percutaneous Tracheostomy ◽  
Johns Hopkins Hospital ◽  
Prospective Data ◽  
Comprehensive Service ◽  
Over Time

Abstract The techniques of performing a tracheostomy has transformed over time. Percutaneous tracheostomy is gaining popularity over open tracheostomy given its advantages and as a result the number of bedside tracheostomies has increased necessitating the need for a Percutaneous Tracheostomy Program. The Percutaneous Tracheostomy Program at the Johns Hopkins Hospital is a comprehensive service that provides care to patients before, during, and after a tracheostomy with a multidisciplinary approach aimed at decreasing complications. Education is provided to patients, families, and health-care professionals who are involved in the management of a tracheostomy. Ongoing prospective data collection serves as a tool for Quality Assurance.

Quality assurance of volumetric modulated arc therapy using Elekta Synergy

2009 ◽  
pp. 1-5 ◽  
Author(s):  
Akihiro Haga ◽  
Keiichi Nakagawa ◽  
Kenshiro Shiraishi ◽  
Saori Itoh ◽  
Atsuro Terahara ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Volumetric Modulated Arc Therapy ◽  
Arc Therapy

Study of quality assurance in prevention and therapy of pressure sores by measurement of overlay pressure with test persons on different prophylaxis systems

Pflege ◽  
2000 ◽  
Vol 13 (5) ◽  
pp. 297-305 ◽  
Author(s):  
Stefan Roales-Welsch ◽  
Antaszek ◽  
Hense ◽  
Pfeiffer ◽  
Freyenhagen ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Pressure Sores ◽  
Os Coccygis ◽  
Prevention And Therapy

In dieser Studie zur Qualitätssicherung in der Prophylaxe und Therapie des Dekubitus durch Auflagedruckmessungen bei Probanden auf sechs Weichlagerungs- und fünf Wechseldrucksystemen war die Zielsetzung, eine Ist-Analyse der am Klinikum eingesetzten Antidekubitushilfsmittel durchzuführen. Außerdem galt es herauszufinden, ob die angewandte Methode der pneumatischen Druckmessung mit Probanden auch im Versorgungsalltag verwendbar ist. Können verlässliche und valide Messdaten erwartet werden, wenn man bei betroffenen Patienten Messungen durchführt? Zur Beantwortung dieser Fragen wurden bei 23/19 Probanden, auch in Seitenlage, durch das Platzieren von Messmatten zwischen Körper und unterschiedliche Antidekubitussysteme Messungen durchgeführt. Bei den Weichlagerungssystemen kann an allen Messorten eine signifikante Druckreduzierung (p < 0,05), am Os coccygis eine hochsignifikante Druckreduzierung (p < 0,01) nachgewiesen werden. Bei den Wechseldrucksystemen liegt der Mittelwert der maximalen Druckbelastung über 12 min bei unterschiedlicher Amplitude (75,47 mmHg–5 mmHg) und verschiedener Frequenz (1,5 min–10 min) zwischen 56,39 mmHg und 38,94 mmHg.

Quality assurance in defense adjudication: An adjudicator workshop for defining and assessing quality

2003 ◽  
Author(s):  
Ralph M. Carney ◽  
Joanne Marshall-Mies ◽  
Daniel G. Youpa ◽  
Whitney B. Helton-Fauth
Keyword(s):  
Quality Assurance
Sign in / Sign up

Export Citation Format

Share Document