scholarly journals Elevated System Energy Expenditure in Sickle Cell Anemia

Anemia ◽  
10.5772/31287 ◽  
2012 ◽  
Author(s):  
Chidi G.
1990 ◽  
Vol 12 (1) ◽  
pp. 119
Author(s):  
N. Gray ◽  
J. Bartlett ◽  
R. Horner ◽  
K. Kolasa ◽  
S. Marcuard ◽  
...  

1999 ◽  
Vol 99 (2) ◽  
pp. 195-199 ◽  
Author(s):  
LORI E KOPP-HOOLIHAN ◽  
MARTA D VAN LOAN ◽  
WILLIAM C MENTZER ◽  
MELVIN B HEYMAN

2001 ◽  
Vol 280 (3) ◽  
pp. E518-E527 ◽  
Author(s):  
Maciej S. Buchowski ◽  
F. Alexander de la Fuente ◽  
Paul J. Flakoll ◽  
Kong Y. Chen ◽  
Ernest A. Turner

Contribution of bone turnover to the hypercatabolic state observed in sickle cell anemia is unknown. We examined the association between markers of bone turnover and basal rates of whole body protein turnover and energy expenditure in 28 adolescents with homozygous sickle cell anemia (HbSS) and in 26 matched controls with normal phenotype (HbAA). Whole body protein breakdown and synthesis were measured using a stable isotope of [15N]glycine, resting energy expenditure was measured by whole room indirect calorimetry, and the rate of pyridinoline cross-link (PYD) excretion in urine and fasting serum levels of the type I procollagen carboxy-terminal propeptide (PICP) were measured with commercial kits. Urinary PYD and serum PICP were significantly elevated in HbSS patients. The increase in procollagen synthesis, indicated by high levels of PICP, was significantly correlated with increased whole body protein synthesis. The increase in type I collagen degradation, indicated by high PYD excretion, was significantly correlated with increased protein breakdown. We conclude that increased rates of bone turnover contribute to the increased rates of protein turnover and energy expenditure observed in adolescents with homozygous sickle cell anemia.


2007 ◽  
Vol 61 (2) ◽  
pp. 233-238 ◽  
Author(s):  
Sylvie A Akohoue ◽  
Sadhna Shankar ◽  
Ginger L Milne ◽  
Jason Morrow ◽  
Kong Y Chen ◽  
...  

2002 ◽  
Vol 76 (6) ◽  
pp. 1335-1344 ◽  
Author(s):  
Maciej S Buchowski ◽  
Kong Y Chen ◽  
Daniel Byrne ◽  
Winfred C Wang

2002 ◽  
Vol 140 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Maciej S. Buchowski ◽  
Karen M. Townsend ◽  
Ruth Williams ◽  
Kong Y. Chen

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