scholarly journals Chemical Carcinogenesis and Nasopharyngeal Carcinoma

10.5772/31185 ◽  
2012 ◽  
Author(s):  
Faqing Tang ◽  
Xiaowei Tang ◽  
Daofa Tian ◽  
Ya Cao
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Chemical Carcinogenesis

scholarly journals A practical method to screen and identify functioning biomarkers in nasopharyngeal carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chengyou Liu ◽  
Peijie Guo ◽  
Leilei Zhou ◽  
Yuhe Wang ◽  
Shuchang Tian ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Chemical Carcinogenesis ◽  
Practical Method ◽  
Functional Enrichment ◽  
Receptor Interaction ◽  
Test Statistics ◽  
Hub Genes ◽  
Inhibitor Activity ◽  
Close Relationship ◽  
Rare Malignancy

AbstractNasopharyngeal carcinoma (NPC) is a rare malignancy, with the unique geographical and ethnically characteristics of distribution. Gene chip and bioinformatics have been employed to reveal regulatory mechanisms in current functional genomics. However, a practical solution addressing the unresolved aspects of microarray data processing and analysis have been long pursuit. This study developed a new method to improve the accuracy of identifying key biomarkers, namely Unit Gamma Measurement (UGM), accounting for multiple hypotheses test statistics distribution, which could reduce the dependency problem. Three mRNA expression profile of NPC were selected to feed UGM. Differentially expressed genes (DEGs) were identified with UGM and hub genes were derived from them to explore their association with NPC using functional enrichment and pathway analysis. 47 potential DEGs were identified by UGM from the 3 selected datasets, and affluent in cysteine-type endopeptidase inhibitor activity, cilium movement, extracellular exosome etc. also participate in ECM-receptor interaction, chemical carcinogenesis, TNF signaling pathway, small cell lung cancer and mismatch repair pathway. Down-regulation of CAPS and WFDC2 can prolongation of the overall survival periods in the patients. ARMC4, SERPINB3, MUC4 etc. have a close relationship with NPC. The UGM is a practical method to identify NPC-associated genes and biomarkers.

An Established Epithelial Cell Line (NPC/HK1) from a Nasopharyngeal Carcinoma - II. A Sem Study

1982 ◽  
Vol 40 ◽  
pp. 224-225
Author(s):  
Li C.L. ◽  
Chew E.C. ◽  
Huang D.P. ◽  
Ho H.C. ◽  
Mak L.S. ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cell ◽  
Surface Morphology ◽  
Cell Line ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Cells In Culture ◽  
Sem Study ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been successfully established from a nasopharyngeal carcinoma of the moderately to well differentiated squamous type. The present communication reports on the surface morphology of the NPC/HK1 cells in culture.

Studies of Epstein-Barr Virus Antigens Using Immunoperoxidase and Immunofluorescence Techniques

1975 ◽  
Vol 33 ◽  
pp. 342-343
Author(s):  
R. Stephens ◽  
K. Traul ◽  
D. Woolf ◽  
P. Gaudreau
Keyword(s):  
Electron Microscopy ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
If Technique ◽  
Infected Cells ◽  
Virus Antigens ◽  
Epstein Barr ◽  
Virus Capsid Antigen ◽  
Antigen Reactivity

A number of antigens have been found associated with persistent EBV infections of lymphoblastoid cells. Identification and localization of these antigens were principally by immunofluorescence (IF) techniques using sera from patients with nasopharyngeal carcinoma (NPC), Burkitt lymphoma (BL), and infectious mononucleosis (IM). Our study was mainly with three of the EBV related antigens, a) virus capsid antigen (VCA), b) membrane antigen (MA), and c) early antigens (EA) using immunoperoxidase (IP) techniques with electron microscopy (EM) to elucidate the sites of reactivity with EBV and EBV infected cells.Prior to labeling with horseradish peroxidase (HRP), sera from NPC, IM, and BL cases were characterized for various reactivities by the indirect IF technique. Modifications of the direct IP procedure described by Shabo and the indirect IP procedure of Leduc were made to enhance penetration of the cells and preservation of antigen reactivity.

A Phase II Trial of Proton Radiotherapy with Chemotherapy for Nasopharyngeal Carcinoma

2014 ◽  
Vol 75 (S 02) ◽  
Author(s):  
Annie Chan ◽  
E. Weyman ◽  
T. Goldsmith ◽  
L. Wirth ◽  
J. Clark ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Proton Radiotherapy

HAZARD: An Expert System for Risk Assessment of Environmental Chemicals

1987 ◽  
Vol 26 (01) ◽  
pp. 13-23 ◽  
Author(s):  
H. W. Gottinger
Keyword(s):  
Expert System ◽  
Structural Information ◽  
Chemical Carcinogenesis ◽  
Structural Features ◽  
Environmental Chemicals ◽  
Chemical Carcinogens ◽  
Carcinogenic Activity ◽  
Current State ◽  
Structure Activity ◽  
Carcinogenic Potential

AbstractThe purpose of this paper is to report on an expert system in design that screens for potential hazards from environmental chemicals on the basis of structure-activity relationships in the study of chemical carcinogenesis, particularly with respect to analyzing the current state of known structural information about chemical carcinogens and predicting the possible carcinogenicity of untested chemicals. The structure-activity tree serves as an index of known chemical structure features associated with carcinogenic activity. The basic units of the tree are the principal recognized classes of chemical carcinogens that are subdivided into subclasses known as nodes according to specific structural features that may reflect differences in carcinogenic potential among chemicals in the class. An analysis of a computerized data base of known carcinogens (knowledge base) is proposed using the structure-activity tree in order to test the validity of the tree as a classification scheme (inference engine).

Sinonasal Morbidity Following Chemoradiation in Nasopharyngeal Carcinoma Patients

2020 ◽  
Author(s):  
Matthew Stewart ◽  
Chandala Chitguppi ◽  
Kira Murphy ◽  
Tawfiq Koury ◽  
Mackenzie O'Connor ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma

Painful ophthalmoplegia secondary to nasopharyngeal carcinoma: a case report

1990 ◽  
Vol 4 (2) ◽  
pp. 112
Author(s):  
Young Bae Roh ◽  
Jhoon Ho Kim ◽  
Joo Young Song ◽  
Boo Sup Oum
Keyword(s):  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Painful Ophthalmoplegia
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