scholarly journals Lipoprotein (a) and Cardiovascular Risk

10.5772/31174 ◽  
2012 ◽  
Author(s):  
Jos Antonio Daz Peromingo
Keyword(s):  
Cardiovascular Risk ◽  
Lipoprotein A

Lipoprotein (a) and Cardiovascular Risk: The Show Must go on

2017 ◽  
Vol 24 (10) ◽  
pp. 989-1006 ◽  
Author(s):  
Niki Katsiki ◽  
Khalid Al-Rasadi ◽  
Dimitri P. Mikhailidis
Keyword(s):  
Cardiovascular Risk ◽  
Lipoprotein A

scholarly journals Lipoprotein(a) and Risk of Type 2 Diabetes

2010 ◽  
Vol 56 (8) ◽  
pp. 1252-1260 ◽  
Author(s):  
Samia Mora ◽  
Pia R Kamstrup ◽  
Nader Rifai ◽  
Børge G Nordestgaard ◽  
Julie E Buring ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Men And Women ◽  
Lipoprotein A ◽  
Incident Type ◽  
Reactive Protein ◽  
Hb A1c ◽  
Hormone Use

BACKGROUND Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein(a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear. METHODS In 26 746 healthy US women (mean age 54.6 years), we prospectively examined baseline Lp(a) concentrations and incident type 2 diabetes (n = 1670) for a follow-up period of 13 years. We confirmed our findings in 9652 Danish men and women with prevalent diabetes (n = 419). Analyses were adjusted for risk factors that included age, race, smoking, hormone use, family history, blood pressure, body mass index, hemoglobin A1c (Hb A1c), C-reactive protein, and lipids. RESULTS Lp(a) was inversely associated with incident diabetes, with fully adjusted hazard ratios (HRs) and 95% CIs for quintiles 2–5 vs quintile 1 of 0.87 (0.75–1.01), 0.80 (0.68–0.93), 0.88 (0.76–1.02), and 0.78 (0.67–0.91); P for trend 0.002. The association was stronger in nonfasting women, for whom respective HRs were 0.79 (0.58–1.09), 0.78 (0.57–1.08), 0.66 (0.46–0.93), and 0.56 (0.40–0.80); P for trend 0.001; P for interaction with fasting status 0.002. When we used Lp(a) ≥10 mg/L and Hb A1c <5% as reference values, the adjusted HRs were 1.62 (0.91–2.89) for Lp(a) <10 mg/L and Hb A1c <5%, 3.50 (3.06–4.01) for Lp(a)≥10 mg/L and Hb A1c 5%–<6.5%, and 5.36 (4.00–7.19) for Lp(a) <10 mg/L and Hb A1c 5%–<6.5%. Results were similar in nonfasting Danish men and women, for whom adjusted odds ratios were 0.75 (0.55–1.03), 0.64 (0.46–0.88), 0.74 (0.54–1.01), and 0.58 (0.42–0.79) for Lp(a) quintiles 2–5 vs quintile 1; P for trend 0.002. CONCLUSIONS Our results indicated that Lp(a) was associated inversely with risk of type 2 diabetes independently of risk factors, in contrast to prior findings of positive associations of Lp(a) with cardiovascular risk.

scholarly journals Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy

2010 ◽  
Vol 51 (10) ◽  
pp. 3055-3061 ◽  
Author(s):  
Stephen J. Nicholls ◽  
W. H. Wilson Tang ◽  
Heather Scoffone ◽  
Danielle M. Brennan ◽  
Jaana Hartiala ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Statin Therapy ◽  
Lipoprotein A
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