scholarly journals Treatment of Chronic Osteomyelitis Using Vancomycin-Impregnated Calcium Sulphate Cement

Bone Grafting ◽  
10.5772/30837 ◽  
2012 ◽  
Author(s):  
Deng Lei ◽  
Ma Zhanzhong ◽  
Yang Huaikuo ◽  
Xue Lei ◽  
Yang Gongbo
Keyword(s):  
Chronic Osteomyelitis ◽  
Calcium Sulphate

The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis

2014 ◽  
Vol 96-B (6) ◽  
pp. 829-836 ◽  
Author(s):  
J. Y. Ferguson ◽  
M. Dudareva ◽  
N. D. Riley ◽  
D. Stubbs ◽  
B. L. Atkins ◽  
...  
Keyword(s):  
Chronic Osteomyelitis ◽  
Calcium Sulphate

Single-stage treatment of chronic osteomyelitis with a new absorbable, gentamicin-loaded, calcium sulphate/hydroxyapatite biocomposite

2016 ◽  
Vol 98-B (9) ◽  
pp. 1289-1296 ◽  
Author(s):  
M. A. McNally ◽  
J. Y. Ferguson ◽  
A. C. K. Lau ◽  
M. Diefenbeck ◽  
M. Scarborough ◽  
...  
Keyword(s):  
Chronic Osteomyelitis ◽  
Calcium Sulphate ◽  
Single Stage

scholarly journals In VivoOsteogenesis of Vancomycin Loaded Nanohydroxyapatite/Collagen/Calcium Sulfate Composite for Treating Infectious Bone Defect Induced by Chronic Osteomyelitis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaojie Lian ◽  
Kezheng Mao ◽  
Xi Liu ◽  
Xiumei Wang ◽  
Fuzhai Cui
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Calcium Sulfate ◽  
Chronic Osteomyelitis ◽  
Rabbit Model ◽  
Calcium Sulphate ◽  
Bone Defects ◽  
Bone Graft Substitute ◽  
Calcium Sulphate Hemihydrate

A novel antibacterial bone graft substitute was developed to repair bone defects and to inhibit related infections simultaneously. This bone composite was prepared by introducing vancomycin (VCM) to nanohydroxyapatite/collagen/calcium sulphate hemihydrate (nHAC/CSH). XRD, SEM, and CCK-8 tests were used to characterize the structure and morphology and to investigate the adhesion and proliferation of murine osteoblastic MC3T3-E1 cell on VCM/nHAC/CSH composite. The effectiveness in restoring infectious bone defects was evaluatedin vivousing a rabbit model of chronic osteomyelitis. Ourin vivoresults implied that the VCM/nHAC/CSH composite performed well both in antibacterial ability and in bone regeneration. This novel bone graft substitute should be very promising for the treatment of bone defect-related infection in orthopedic surgeries.

Chronic Osteomyelitis Treatment: A Clinical and Pharmaco-Kinetic Study of Vancomycin Impregnated Calcium Sulphate

2015 ◽  
Vol 5 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Lifeng Shen ◽  
Yu Dong ◽  
Chun Zhang ◽  
Qiaofeng Guo ◽  
Dan Shou ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Chronic Osteomyelitis ◽  
Calcium Sulphate

scholarly journals Treatment of Cavitary Bone Defects in Chronic Osteomyelitis: Bioactive glass S53P4 vs. Calcium Sulphate Antibiotic Beads

2017 ◽  
Vol 2 (4) ◽  
pp. 194-201 ◽  
Author(s):  
Albert Ferrando ◽  
Joan Part ◽  
Jose Baeza
Keyword(s):  
Postoperative Complications ◽  
Hospital Stay ◽  
Chronic Osteomyelitis ◽  
Average Length ◽  
Length Of Hospital Stay ◽  
Calcium Sulphate ◽  
Bone Defects ◽  
Group 2 ◽  
Group 1

Abstract. Aim: To evaluate the efficacy of bioglass (BAG-S53P4) in the treatment of patients with chronic osteomyelitis and compare the results with calcium sulphate antibiotic beads in one medical centre.Methods: Retrospective analysis of 25 cases. Inclusion criteria: patients diagnosed clinically and radiographically of osteomyelitis and treated surgically (Group 1: cavitary bone defects treated with bioglass and Group 2: cavitary bone defects treated with calcium sulphate antibiotic beads) during the period of 2014 and 2015 in one medical centre.Results: Patients in group 1 (bioglass treatment): total of 12 patients (11 males and 1 female) with mean age: 50 years (30-86). Average length of hospital stay was 22 days and mean follow-up time: 23 months (16-33). Mean erythrocyte sedimentation rate (ESR) and mean c-reactive protein (CRP) before surgery: 55mm/hr and 54 mg/L, respectively. Mean ESR and mean CRP in last blood exam: 18 mm/hr and 8 mg/L, respectively. There were 2 postoperative complications: seroma formation and delayed wound healing. Only 1 patient had recurrence of infection.Patients in group 2 (calcium sulphate antibiotic beads treatment): total of 13 patients (9 males and 4 females) with mean age: 48 years (17-67). Average length of hospital stay was 21 days and mean follow-up time 22 months (16-29). Mean ESR and mean CRP before surgery: 51mm/hr and 41 mg/L, respectively. Mean ESR and mean CRP in last blood test: 15 mm/hr and 11 mg/L. 2 postoperative complications were registered: chronic expanding hematoma of the muscle flap donor site and seroma formation. 1 patient had recurrence of infection. Overall, there were no differences in recurrence of infection, p=0.740 and in complication rate, p=0.672. 11 (91,7%) patients in group 1 and 12 (92,3%) patients in group 2 showed no signs of recurrence of infection both clinically and radiologically at final follow-up.The most frequent cause of osteomyelitis in group 1 was post traumatic while a postsurgical aetiology was more frequent in group 2. The distal tibia was the most common location. The most frequent pathogen isolated in both groups was methicillin sensible staphylococcus aureus.Conclusions: An advance in treatment of patients with cavitary bone defects in chronic osteomyelitis is the use of synthetic bone substitutes although current evidence is low. In this study, we demonstrate how bioglass without local antibiotics and calcium sulphate antibiotic beads are both equally effective treatment options. Overall, there were no differences between groups in mean hospital stay, complication rates and recurrence of infection.

scholarly journals Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

2017 ◽  
Vol 2 (1) ◽  
pp. 38-51 ◽  
Author(s):  
Jamie Ferguson ◽  
Michael Diefenbeck ◽  
Martin McNally
Keyword(s):  
Animal Studies ◽  
Chronic Osteomyelitis ◽  
Treatment Protocol ◽  
Calcium Sulphate ◽  
Success Rates ◽  
Osseous Defect ◽  
Systemic Antibiotics ◽  
Local Release ◽  
Osseous Defects ◽  
Local Antibiotic

Abstract. Local release of antibiotic has advantages in the treatment of chronic osteomyelitis and infected fractures. The adequacy of surgical debridement is still key to successful clearance of infection but local antibiotic carriers seem to afford greater success rates by targeting the residual organisms present after debridement and delivering much higher local antibiotic concentrations compared with systemic antibiotics alone. Biodegradable ceramic carriers can be used to fill osseous defects, which reduces the dead space and provides the potential for subsequent repair of the osseous defect as they dissolve away. A dissolving ceramic antibiotic carrier also raises the possibility of single stage surgery with definitive closure and avoids the need for subsequent surgery for spacer removal.In this article we provide an overview of the properties of various biodegradable ceramics, including calcium sulphate, the calcium orthophosphate ceramics, calcium phosphate cement and polyphasic carriers. We summarise the antibiotic elution properties as investigated in previous animal studies as well as the clinical outcomes from clinical research investigating their use in the surgical management of chronic osteomyelitis.Calcium sulphate pellets have been shown to be effective in treating local infection, although newer polyphasic carriers may support greater osseous repair and reduce the risk of further fracture or the need for secondary reconstructive surgery. The use of ceramic biocomposites to deliver antibiotics together with BMPs, bisphosphonates, growth factors or living cells is under investigation and merits further study.We propose a treatment protocol, based on the Cierny-Mader classification, to help guide the appropriate selection of a suitable ceramic antibiotic carrier in the surgical treatment of chronic osteomyelitis.

Comparison of the use of antibiotic-loaded calcium sulphate and wound irrigation-suction in the treatment of lower limb chronic osteomyelitis

Injury ◽  
2019 ◽  
Vol 50 (2) ◽  
pp. 508-514 ◽  
Author(s):  
Cheng-He Qin ◽  
Hong-An Zhang ◽  
Yu-Han Chee ◽  
Astuti Pitarini ◽  
Abdulnassir Adem Ali
Keyword(s):  
Lower Limb ◽  
Chronic Osteomyelitis ◽  
Calcium Sulphate ◽  
Wound Irrigation

Diagnosis of chronic osteomyelitis by combined 99mTc-bone and 99mTc-anti-granulocyte scintigraphy

2016 ◽  
Vol 55 (06) ◽  
pp. N60-N61
Author(s):  
Anne Frölich ◽  
Gotthard Knoll ◽  
Manfred Bähre ◽  
Christoph Neumann
Keyword(s):  
Chronic Osteomyelitis ◽  
Granulocyte Scintigraphy
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