scholarly journals Mammographic Density Under Hormonal and Hormone-Like Treatments

10.5772/30749 ◽  
2012 ◽  
Author(s):  
erban Nastasia
Keyword(s):  
Mammographic Density

Mammographic Density Categories

2002 ◽  
Vol 178 (1) ◽  
pp. 242-243 ◽  
Author(s):  
Ferris M. Hall
Keyword(s):  
Mammographic Density

scholarly journals Volumetric Mammographic Density: Heritability and Association With Breast Cancer Susceptibility Loci

2014 ◽  
Vol 106 (12) ◽  
pp. dju334-dju334 ◽  
Author(s):  
J. S. Brand ◽  
K. Humphreys ◽  
D. J. Thompson ◽  
J. Li ◽  
M. Eriksson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammographic Density ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Susceptibility Loci

scholarly journals Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?

2021 ◽  
Author(s):  
Gina Reye ◽  
Xuan Huang ◽  
Larisa M. Haupt ◽  
Ryan J. Murphy ◽  
Jason J. Northey ◽  
...  
Keyword(s):  
Mammographic Density ◽  
Positive Feedback ◽  
Weight Bearing ◽  
Fibrous Tissue ◽  
Feedback Mechanism ◽  
Mechanical Force ◽  
Mechanical Stiffness ◽  
Mechanical Pressure ◽  
Fibrous Stroma ◽  
High Mammographic Density

AbstractRegions of high mammographic density (MD) in the breast are characterised by a proteoglycan (PG)-rich fibrous stroma, where PGs mediate aligned collagen fibrils to control tissue stiffness and hence the response to mechanical forces. Literature is accumulating to support the notion that mechanical stiffness may drive PG synthesis in the breast contributing to MD. We review emerging patterns in MD and other biological settings, of a positive feedback cycle of force promoting PG synthesis, such as in articular cartilage, due to increased pressure on weight bearing joints. Furthermore, we present evidence to suggest a pro-tumorigenic effect of increased mechanical force on epithelial cells in contexts where PG-mediated, aligned collagen fibrous tissue abounds, with implications for breast cancer development attributable to high MD. Finally, we summarise means through which this positive feedback mechanism of PG synthesis may be intercepted to reduce mechanical force within tissues and thus reduce disease burden.

64P Mammographic density to predict response to neoadjuvant chemotherapy for breast cancer

2021 ◽  
Vol 32 ◽  
pp. S49
Author(s):  
S. Di Cosimo ◽  
C. Depretto ◽  
R. Miceli ◽  
P. Baili ◽  
M. Sant ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Mammographic Density ◽  
Response To Neoadjuvant Chemotherapy

Mammographic density changes following BC treatment

2021 ◽  
Vol 76 ◽  
pp. 88-97
Author(s):  
Ibrahem H. Kanbayti ◽  
William I.D. Rae ◽  
Mark F. McEntee ◽  
Ernest U. Ekpo
Keyword(s):  
Mammographic Density

scholarly journals Assessing Biomarkers of Breast Cancer Risk in Underserved Women in a Midwestern County

2021 ◽  
Vol 12 ◽  
pp. 215013272110177
Author(s):  
Marla A. DeWitt ◽  
Ivana T. Croghan ◽  
Celine M. Vachon ◽  
Thomas D. Thacher ◽  
Marcia R. Venegas Pont ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mammographic Density ◽  
Small Sample Size ◽  
Vitamin D Insufficiency ◽  
Screening Mammography ◽  
Small Sample ◽  
Vitamin D Status ◽  
Small Pilot Study ◽  
Unexpected Findings

Objective: The primary aim of this study was to evaluate the feasibility of collecting risk factor information and accessing digitized mammographic data in a medically marginalized population. A secondary aim was to examine the association between vitamin D status and mammographic density. Methods: Breast-screening examinations were provided for age-appropriate patients, and a referral for no-cost screening mammography was offered. Study participants were asked to undergo 25-hydroxyvitamin D testing at mammography and 1-year follow-up. Results: Of 62 women approached, 35 (56%) consented to participate. Of 32 participants who had baseline mammography, the median mammographic density measured by VolparaDensity (Volpara Solutions Limited) was 5.7%. After 1 year, 9 women obtained follow-up mammograms, with a median density of 5.7%. Vitamin D status was measured for 31 participants at baseline and 13 participants in the following year. Insufficient vitamin D status (<30 ng/mL) was noted in 77% at each time point. Mammographic density was not significantly correlated with vitamin D status ( P = .06). Conclusions: On the basis of this small pilot study, vitamin D insufficiency is common in this study population. Owing to the small sample size, an association between vitamin D insufficiency and breast density was not clear. Additional unexpected findings included substantial barriers in initial access to care and longitudinal follow-up in this population. Further study of these issues is needed.

scholarly journals Variation in Inflammatory Cytokine/Growth-Factor Genes and Mammographic Density in Premenopausal Women Aged 50–55

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65313 ◽  
Author(s):  
Ali Ozhand ◽  
Eunjung Lee ◽  
Anna H. Wu ◽  
Merete Ellingjord-Dale ◽  
Lars A. Akslen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mammographic Density ◽  
Inflammatory Cytokine ◽  
Premenopausal Women ◽  
Growth Factor Genes
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