scholarly journals Hypothyroidism and Thyroid Function Alterations During the Neonatal Period

10.5772/30713 ◽  
2012 ◽  
Author(s):  
Susana Ares ◽  
Jos Quero ◽  
Beln Senz-Rico de Santiago ◽  
Gabriela Morreale de Escobar
Keyword(s):  
Thyroid Function ◽  
Neonatal Period

Temporal Evaluation of the Thyroid Function of Rats Programed by Leptin Treatment on the Neonatal Period

2006 ◽  
Vol 38 (12) ◽  
pp. 827-831 ◽  
Author(s):  
F. Toste ◽  
S. Alves ◽  
S. Dutra ◽  
I. Bonomo ◽  
P. Lisboa ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Neonatal Period

Regional Variations of Iodine Nutrition and Thyroid Function during the Neonatal Period in Europe

Neonatology ◽  
1986 ◽  
Vol 49 (6) ◽  
pp. 322-330 ◽  
Author(s):  
F. Delange ◽  
P. Heidemann ◽  
P. Bourdoux ◽  
A. Larsson ◽  
R. Vigneri ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Neonatal Period ◽  
Iodine Nutrition ◽  
Regional Variations

Thyroid Function and Plasma Tyrosine in the Neonatal Period

1967 ◽  
Vol 56 (2) ◽  
pp. 141-150 ◽  
Author(s):  
K. SIERSBÆK-NIELSEN ◽  
J. MØLHOLM HANSEN
Keyword(s):  
Thyroid Function ◽  
Neonatal Period ◽  
Plasma Tyrosine

scholarly journals Serum Free Thyroxine and Free Triiodothyronine Concentrations in Healthy Fullterm, Preterm and Sick Preterm Neonates

1987 ◽  
Vol 24 (5) ◽  
pp. 461-465 ◽  
Author(s):  
Rhys John ◽  
Fiona J Bamforth
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Neonatal Period ◽  
Free Thyroxine ◽  
Preterm Neonates ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Widespread Application ◽  
Early Neonatal Period ◽  
Free Thyroid Hormone

There are few data available on free thyroid hormone concentrations in the early neonatal period. With the widespread application of screening procedures for detecting congenital hypothyroidism there is a need for reference ranges in neonates. In this study we have evaluated thyroid function in healthy fullterm and preterm neonates, and sick neonates all within one to 10 days postnatal age. Our data indicates that free thyroxine but not free triiodothyronine is higher in fullterm neonates than the adult reference range and that both free thyroid hormone concentrations are reduced in healthy and sick preterm neonates as compared to fullterm neonates. Assessment of thyroid function in the early neonatal period needs to take into account these changes particularly in preterm and sick preterm neonates.

scholarly journals Maternal Hypothyroidism Delayed Retinal Opsin-Development in the Neonatal Period: Analysis of TRH-Deficient Mice

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A851-A852
Author(s):  
Kazuma Saito ◽  
Kazuhiko Horiguchi ◽  
Battsetseg Buyandalai ◽  
Ayaka Nishikido ◽  
Takashi Okamura ◽  
...  
Keyword(s):  
Protein Expression ◽  
Thyroid Function ◽  
Thyroid Hormone Receptor ◽  
Neonatal Period ◽  
Photoreceptor Cells ◽  
Expression Level ◽  
Central Hypothyroidism ◽  
Expression Levels ◽  
Opsin Expression ◽  
Deficient Mice

Abstract Introduction: Retinal cone photoreceptor cells contain short (S) and medium (M) wavelength opsins, which are light-sensitive substances involved in color vision and visual acuity by sensing lights of different wavelengths. Thyroid hormones promote M-opsin expression and suppress S-opsin expression during the differentiation of cone photoreceptors. It was previously reported that M-opsin expression was delayed and S-opsin expression increased in TSH receptor-deficient mice and methimazole-induced hypothyroid mice. In addition, no M-opsin expression and increased S-opsin expression were observed in thyroid hormone receptor (TR) β2-deficient mice (Ng L et al, Nature Genetics. 2001; 27(1): 94-98.). This suggested that impaired thyroid function affects opsin development. We therefore examined retinal development in TRH-deficient mice, which are a model of central hypothyroidism established in our laboratory. Methods: We performed HE staining of the retina at postnatal 30 days and electroretinography at postnatal 10 weeks using TRH-/- and wild-type (WT) mice. We also examined expression levels of S/M opsin mRNA in WT, TRH-/- and TRH-/- pups born from TRH-/- dams at postnatal 12,17 and 30 days, and TRβΔ337T knock-in mice (TRβmut/mut) at postnatal 30 days. Furthermore, we performed immunohistochemistry to examine S/M opsin protein expression in these mice. Results: The retinal structures by HE staining and retinal functions by electroretinography in TRH-/- mice were unchanged compared with those in WT mice. Although M-opsin expression was not detected and S-opsin expression was higher in TRβmut/mut mice than in WT mice, the mRNA and protein expression levels of S/M-opsin did not significantly differ between TRH-/- pups born from TRH+/- dams and WT pups at all postnatal days. TRH-/- pups born from TRH-/- dams exposed to maternal hypothyroidism had similar serum total T4 levels to TRH-/- pups born from TRH+/- with normal maternal thyroid function. In contrast, the mRNA expression level of M-opsin was significantly lower (1.00±0.06 vs 0.64±0.05: mean ± SE, p<0.01) and the protein expression level was lower in TRH-/- pups born from TRH-/- dams than in WT pups at postnatal 12 days. However, these differences disappeared after postnatal 17 days, and there was no difference in M-opsin expression in TRH-/- pups born from TRH-/- dams compared with WT pups. Conclusions: Although no delay in opsin development was observed in TRH-/- pups born from TRH+/- dams, TRH-/- pups born from central hypothyroid dams exhibited delayed opsin development, suggesting that maternal hypothyroidism affects the development of retinal opsin in the neonatal period.

Long-Term Environmental Exposure to Perchlorate Through Drinking Water and Thyroid Function During Pregnancy and the Neonatal Period

Thyroid ◽  
2005 ◽  
Vol 15 (9) ◽  
pp. 963-975 ◽  
Author(s):  
Rafael Téllez Téllez ◽  
Patricio Michaud Chacón ◽  
Carlos Reyes Abarca ◽  
Ben C. Blount ◽  
Cynthia B. Van Landingham ◽  
...  
Keyword(s):  
Drinking Water ◽  
Environmental Exposure ◽  
Thyroid Function ◽  
Neonatal Period
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