scholarly journals Protection of Motor Neurons in Pre-Symptomatic Individuals Carrying SOD 1 Mutations: Results of Motor Unit Number Estimation (MUNE) Electrophysiology

10.5772/30259 ◽  
2012 ◽  
Author(s):  
Arun Aggarwal
Keyword(s):  
Motor Unit ◽  
Motor Neurons ◽  
Motor Unit Number Estimation

The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1G93A mice

2012 ◽  
Vol 123 (10) ◽  
pp. 2080-2091 ◽  
Author(s):  
S.T. Ngo ◽  
F. Baumann ◽  
P.G. Ridall ◽  
A.N. Pettitt ◽  
R.D. Henderson ◽  
...  
Keyword(s):  
Motor Unit ◽  
Motor Neurons ◽  
Wild Type ◽  
Sod1g93a Mice ◽  
Motor Unit Number Estimation ◽  
The Relationship

scholarly journals Persistent West Nile Virus Associated with a Neurological Sequela in Hamsters Identified by Motor Unit Number Estimation

2009 ◽  
Vol 83 (9) ◽  
pp. 4251-4261 ◽  
Author(s):  
Venkatraman Siddharthan ◽  
Hong Wang ◽  
Neil E. Motter ◽  
Jeffery O. Hall ◽  
Robert D. Skinner ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Motor Unit ◽  
Motor Neurons ◽  
Positive Staining ◽  
Neurological Sequela ◽  
West Nile ◽  
Hamster Model ◽  
Motor Unit Number Estimation ◽  
Central Nervous Systems

ABSTRACT To investigate the hypothesis that neurological sequelae are associated with persistent West Nile virus (WNV) and neuropathology, we developed an electrophysiological motor unit number estimation (MUNE) assay to measure the health of motor neurons temporally in hamsters. The MUNE assay was successful in identifying chronic neuropathology in the spinal cords of infected hamsters. MUNE was suppressed at days 9 to 92 in hamsters injected subcutaneously with WNV, thereby establishing that a long-term neurological sequela does occur in the hamster model. MUNE suppression at day 10 correlated with the loss of neuronal function as indicated by reduced choline acetyltransferase staining (R 2 = 0.91). Between days 10 and 26, some α-motor neurons had died, but further neuronal death was not detected beyond day 26. MUNE correlated with disease phenotype, because the lowest MUNE values were detected in paralyzed limbs. Persistent WNV RNA and foci of WNV envelope-positive cells were identified in the central nervous systems of all hamsters tested from 28 to 86 days. WNV-positive staining colocalized with the neuropathology, which suggested that persistent WNV or its products contributed to neuropathogenesis. These results established that persistent WNV product or its proteins cause dysfunction, that WNV is associated with chronic neuropathological lesions, and that this neurological sequela is effectively detected by MUNE. Inasmuch as WNV-infected humans can also experience a poliomyelitis-like disease where motor neurons are damaged, MUNE may also be a sensitive clinical or therapeutic marker for those patients.

scholarly journals Motor Unit Number Estimation in Neuromuscular Disease

2008 ◽  
Vol 35 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Omid Rashidipour ◽  
K. Ming Chan
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Unit ◽  
Neuromuscular Disease ◽  
Muscular Atrophy ◽  
Neuromuscular Diseases ◽  
Neuronal Loss ◽  
Response To Treatment ◽  
Motor Unit Number Estimation ◽  
Electrophysiological Method ◽  
Lateral Sclerosis

Motor unit number estimation (MUNE) is an electrophysiological method designed to quantify motor unit loss in target muscles of interest. Most of the techniques are noninvasive and are therefore well suited for longitudinal monitoring. In this brief review, we describe the more commonly used techniques and their applications in amyotrophic lateral sclerosis, poliomyelitis, spinal muscular atrophy and hereditary sensorimotor neuropathies. Findings in some of these studies offer important pathophysiological insights. Since conventional electrophysiologic methods are not sensible measures of motor neuronal loss, MUNE could play a potentially important role in the diagnosis, monitoring of disease progression and response to treatment in neuromuscular diseases in which motor unit loss is a major feature.

F37. Motor unit number estimation methods for quantification of motor unit loss in Guillain Barre Syndrome

2018 ◽  
Vol 129 ◽  
pp. e80
Author(s):  
Christina S. Nielsen ◽  
Michael Vaeggemose ◽  
Anna B. Jacobsen ◽  
Anders Fuglsang-Frederiksen ◽  
Henning Andersen ◽  
...  
Keyword(s):  
Motor Unit ◽  
Guillain Barre Syndrome ◽  
Estimation Methods ◽  
Motor Unit Number Estimation ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

32. Contribution of far-field potentials on motor unit number estimation (MUNE)

2012 ◽  
Vol 123 (9) ◽  
pp. e94
Author(s):  
Mana Higashihara ◽  
Masahiro Sonoo ◽  
Tomotaka Yamamoto ◽  
Yu Nagashima ◽  
Yasuo Terao ◽  
...  
Keyword(s):  
Motor Unit ◽  
Far Field ◽  
Field Potentials ◽  
Motor Unit Number Estimation
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