scholarly journals Peripheral Nerve Reconstruction with Autologous Grafts

10.5772/29915 ◽  
2012 ◽  
Author(s):  
Fabrizio Schonauer ◽  
Sergio Marlino ◽  
Stefano Avvedimento ◽  
Guido Mole
Keyword(s):  
Peripheral Nerve ◽  
Nerve Reconstruction ◽  
Autologous Grafts

Biological and Synthetic Conduits in Peripheral Nerve Repair: A Comparative Experimental Study

1995 ◽  
Vol 18 (4) ◽  
pp. 225-230 ◽  
Author(s):  
R. Giardino ◽  
N. Nicolialdini ◽  
G. Perego ◽  
G. Cella ◽  
M.C. Maltarello ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Wistar Rats ◽  
Nerve Repair ◽  
General Anesthetic ◽  
Nerve Reconstruction ◽  
Peripheral Nerve Repair ◽  
Significant Difference ◽  
Different Types ◽  
Autologous Grafts ◽  
Better Than

Two different types of conduits, one biological, obtained with homologous glutaraldehyde preserved vein segments and the other synthetic bioabsorbable, made with Poly [L-lactide-co-6-caprolactone], were evaluated as guides for nerve repair in alternative to autologous grafts in an experimental animal model. Under general anesthetic, the ischiatic nerve of a number Wistar rats was transected to create a 1 cm gap, which was then repaired by means of the conduits or autologous grafts. Controls were performed at 1, 3 and 6 months; nerve regeneration was effective with both conduits, but the count of myelinated axons showed a significant difference between the synthetic and biological tubes (p<0.001). The Poly [L-lactide-co-6-caprolactone] guide was still intact 30 days after implant; progressive signs of degradation were present at 90 and 180 days. These results show that the synthetic conduits are better than those obtained with preserved vein segments and might be considered in alternative to autologous grafts in peripheral nerve reconstruction

Processed nerve allografts for peripheral nerve reconstruction: A multicenter study of utilization and outcomes in sensory, mixed, and motor nerve reconstructions

Microsurgery ◽  
2011 ◽  
Vol 32 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Darrell N. Brooks ◽  
Renata V. Weber ◽  
Jerome D. Chao ◽  
Brian D. Rinker ◽  
Jozef Zoldos ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Multicenter Study ◽  
Motor Nerve ◽  
Nerve Reconstruction

Experimental Study for Peripheral Nerve Reconstruction using Skeletal Muscle and Omentum

1990 ◽  
Vol 25 (4) ◽  
pp. 1233
Author(s):  
Jae Myeung Chun ◽  
Byung Woo Ahn ◽  
Gye Yong Song ◽  
Sang Youp Lee ◽  
Bong Jin Lee
Keyword(s):  
Skeletal Muscle ◽  
Experimental Study ◽  
Peripheral Nerve ◽  
Nerve Reconstruction

Peripheral nerve reconstruction by autograft

Injury ◽  
2002 ◽  
Vol 33 (7) ◽  
pp. 627-631 ◽  
Author(s):  
Viktor Matejčı́k
Keyword(s):  
Peripheral Nerve ◽  
Nerve Reconstruction

scholarly journals Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
D. Grinsell ◽  
C. P. Keating
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Surgical Techniques ◽  
The Body ◽  
Sensory Function ◽  
Nerve Reconstruction ◽  
Nerve Transfers ◽  
Experimental Therapies ◽  
Surgical Options

Unlike other tissues in the body, peripheral nerve regeneration is slow and usually incomplete. Less than half of patients who undergo nerve repair after injury regain good to excellent motor or sensory function and current surgical techniques are similar to those described by Sunderland more than 60 years ago. Our increasing knowledge about nerve physiology and regeneration far outweighs our surgical abilities to reconstruct damaged nerves and successfully regenerate motor and sensory function. It is technically possible to reconstruct nerves at the fascicular level but not at the level of individual axons. Recent surgical options including nerve transfers demonstrate promise in improving outcomes for proximal nerve injuries and experimental molecular and bioengineering strategies are being developed to overcome biological roadblocks limiting patient recovery.

scholarly journals Introduction: the value of peripheral nerve surgery

2018 ◽  
Vol 44 (videosuppl1) ◽  
pp. Intro
Author(s):  
Robert J. Spinner ◽  
Holly S. Gilmer ◽  
Gregory R. Trost
Keyword(s):  
Peripheral Nerve ◽  
Patient Outcomes ◽  
Surgical Techniques ◽  
Nerve Transfer ◽  
Nerve Reconstruction ◽  
Tumor Biopsy ◽  
Nerve Decompression ◽  
Peripheral Nerve Surgery ◽  
Nerve Surgery ◽  
Logical Extension

If a single picture is worth a thousand words, then a video, by logical extension, would be priceless. This edition showcases peripheral nerve surgery in all its grandeur and preserves it for posterity. Classic and novel surgical techniques are shown related to tumor biopsy or resection; nerve decompression for entrapment; and nerve reconstruction with direct repair or nerve transfer. Akin to a nautical chart filled with detailed maps for sailors, this Neurosurgical Focus Video Atlas provides navigational tools for neurosurgeons. The shared underlying message is that a sound knowledge of anatomy can lead to innovation (i.e., creative approaches or solutions) and excellence (i.e., improved patient outcomes).

Progress in peripheral nerve reconstruction

1990 ◽  
Vol 14 (6) ◽  
pp. 733-747 ◽  
Author(s):  
Hanno Millesi
Keyword(s):  
Peripheral Nerve ◽  
Nerve Reconstruction

scholarly journals Reviving Matrix for Nerve Reconstruction in Rabbit Model of Chronic Peripheral Nerve Injury With Massive Loss Defect

2021 ◽  
Vol 7 ◽  
Author(s):  
Shimon Rochkind ◽  
Mara Almog ◽  
Sigal Meilin ◽  
Zvi Nevo
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Rabbit Model ◽  
Nerve Graft ◽  
Human Condition ◽  
Nerve Reconstruction ◽  
Chronic Injury ◽  
Empty Tube

Background and Aims: The aim of this study was to investigate the innovative guiding regenerative gel (GRG) and antigliotic GRG (AGRG) fillings for nerve conduits, prepared with Food and Drug Administration (FDA)-approved agents and expected to provide an alternative to autologous nerve graft and to enable reconnection of massive nerve gaps in a rabbit model of chronic peripheral nerve injury with massive loss defect that simulates the human condition of chronic injury with a large gap.Methods: The components and dosimetry for GRG and AGRG formulations were investigated in vitro on nerve cell culture and in vivo on 10-mm reconstructed sciatic nerves of 72 rats using different concentrations of agents and completed on a rabbit model of delayed (chronic) complete peripheral nerve injury with a 25-mm gap. Forty rabbits underwent delayed (9 weeks after complete injury of the tibial portion of the sciatic nerve) nerve tube reconstruction of a gap that is 25 mm long. GRG and AGRG groups were compared with autologous and empty tube reconstructed groups. Rats and rabbits underwent electrophysiological and histochemical assessments (19 weeks for rats and 40 weeks for rabbits).Results: Application of AGRG showed a significant increase of about 78% in neurite length per cell and was shown to have the most promising effect on neuronal outgrowth, with total number of neurites increasing by 4-fold. The electrophysiological follow-up showed that AGRG treatment is most promising for the reconstruction of the tibial portion of the sciatic nerve with a critical gap of 25 mm. The beneficial effect of AGRG was found when compared with the autologous nerve graft reconstruction. Thirty-one weeks post the second surgery (delayed reconstruction), histochemical observation showed significant regeneration after using AGRG neurogel, compared with the empty tube, and succeeded in significantly regenerating the nerve, as well as the autologous nerve graft, which was almost similar to a healthy nerve.Conclusion: We demonstrate that in the model of delayed peripheral nerve repair with massive loss defect, the application of AGRG led to a stronger nerve recovery and can be an alternative to autologous nerve graft.

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