scholarly journals The Role of Anopheles gambiae P450 Cytochrome in Insecticide Resistance and Infection

10.5772/29217 ◽  
2012 ◽  
Author(s):  
Rute Flix ◽  
Henrique Silveir
Keyword(s):  
Insecticide Resistance ◽  
Anopheles Gambiae

scholarly journals Mosquitoes cloak their legs to resist insecticides

2019 ◽  
Vol 286 (1907) ◽  
pp. 20191091 ◽  
Author(s):  
Vasileia Balabanidou ◽  
Mary Kefi ◽  
Michalis Aivaliotis ◽  
Venetia Koidou ◽  
Juan R. Girotti ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Anopheles Gambiae ◽  
Malaria Vector ◽  
Malaria Incidence ◽  
Detoxification Enzymes ◽  
Female Mosquito ◽  
Cuticular Proteins ◽  
Year 2000 ◽  
Major Malaria Vector

Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae ; however, the emergence of striking resistant phenotypes suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared with susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.

scholarly journals Insecticide resistance status of malaria vectors Anopheles gambiae (s.l.) of southwest Burkina Faso and residual efficacy of indoor residual spraying with microencapsulated pirimiphos-methyl insecticide

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Dieudonné Diloma Soma ◽  
Barnabas Zogo ◽  
Domonbabele François de Sales Hien ◽  
Aristide Sawdetuo Hien ◽  
Didier Alexandre Kaboré ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Burkina Faso ◽  
Anopheles Gambiae ◽  
Local Population ◽  
Residual Activity ◽  
Indoor Residual Spraying ◽  
Susceptible Strain ◽  
Malaria Vectors ◽  
Pirimiphos Methyl ◽  
Residual Efficacy

Abstract Background The rapid spread of insecticide resistance in malaria vectors and the rebound in malaria cases observed recently in some endemic areas underscore the urgent need to evaluate and deploy new effective control interventions. A randomized control trial (RCT) was conducted with the aim to investigate the benefit of deploying complementary strategies, including indoor residual spraying (IRS) with pirimiphos-methyl in addition to long-lasting insecticidal nets (LLINs) in Diébougou, southwest Burkina Faso. Methods We measured the susceptibility of the Anopheles gambiae (s.l.) population from Diébougou to conventional insecticides. We further monitored the efficacy and residual activity of pirimiphos-methyl on both cement and mud walls using a laboratory susceptible strain (Kisumu) and the local An. gambiae (s.l.) population. Results An. gambiae (s.l.) from Diébougou was resistant to DDT, pyrethroids (deltamethrin, permethrin and alphacypermethrin) and bendiocarb but showed susceptibility to organophosphates (pirimiphos-methyl and chlorpyrimiphos-methyl). A mixed-effect generalized linear model predicted that pirimiphos-methyl applied on cement or mud walls was effective for 210 days against the laboratory susceptible strain and 247 days against the local population. The residual efficacy of pirimiphos-methyl against the local population on walls made of mud was similar to that of cement (OR = 0.792, [0.55–1.12], Tukey’s test p-value = 0.19). Conclusions If data on malaria transmission and malaria cases (as measured trough the RCT) are consistent with data on residual activity of pirimiphos-methyl regardless of the type of wall, one round of IRS with pirimiphos-methyl would have the potential to control malaria in a context of multi-resistant An. gambiae (s.l.) for at least 7 months.

scholarly journals Multiple insecticide resistance mechanisms in Anopheles gambiae s.l. populations from Cameroon, Central Africa

2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Philippe Nwane ◽  
Josiane Etang ◽  
Mouhamadou Chouaїbou ◽  
Jean Claude Toto ◽  
Alphonsine Koffi ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Anopheles Gambiae ◽  
Central Africa ◽  
Resistance Mechanisms ◽  
Anopheles Gambiae S.L

scholarly journals Effects of piperonyl butoxide on the toxicity of the organophosphate temephos and the role of esterases in the insecticide resistance of Aedes aegypti

2014 ◽  
Vol 47 (5) ◽  
pp. 579-582 ◽  
Author(s):  
Boscolli Barbosa Pereira ◽  
Jean Ezequiel Limongi ◽  
Edimar Olegário de Campos Júnior ◽  
Denis Prudencio Luiz ◽  
Warwick Estevam Kerr
Keyword(s):  
Aedes Aegypti ◽  
Insecticide Resistance ◽  
Piperonyl Butoxide

Insecticide resistance in the Anopheles gambiae complex in Benin: a nationwide survey

2010 ◽  
Vol 25 (3) ◽  
pp. 256-267 ◽  
Author(s):  
L. DJOGBÉNOU ◽  
N. PASTEUR ◽  
M. AKOGBÉTO ◽  
M. WEILL ◽  
F. CHANDRE
Keyword(s):  
Insecticide Resistance ◽  
Anopheles Gambiae ◽  
Nationwide Survey ◽  
Gambiae Complex ◽  
Anopheles Gambiae Complex
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