scholarly journals Novel Biomarkers in Pancreatic Cancer

10.5772/29001 ◽  
2012 ◽  
Author(s):  
Simona O. ◽  
Cristiana Tanase ◽  
Radu Albulescu ◽  
Anca Botezatu ◽  
Irinel Popescu
Keyword(s):  
Pancreatic Cancer ◽  
Novel Biomarkers

scholarly journals Clinical Scenarios Emerging from Combined Immunophenotypic, Molecular and Morphologic Analysis of Pancreatic Cancer: the Good, the Bad and the Ugly Scenario

Cancers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 968 ◽  
Author(s):  
Karamitopoulou ◽  
Gloor
Keyword(s):  
Pancreatic Cancer ◽  
Immune Cell ◽  
Ductal Adenocarcinoma ◽  
Significant Heterogeneity ◽  
Dismal Prognosis ◽  
Clinical Scenarios ◽  
Novel Biomarkers ◽  
Morphologic Analysis ◽  
Dynamic Interplay ◽  
Immune Cell Infiltrates

: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with increasing incidence and dismal prognosis. The composition of the immune cell infiltrates in the tumor microenvironment (TME) and the dynamic interplay between cancer- and immune cells can influence and/or be influenced by tumor-intrinsic characteristics like molecular profiles and tumor cell morphology. The combined analyses of pancreatic cancer by using morphologic, genetic, and immunologic features help us understand the significant heterogeneity of the TME and recognize the different mechanisms of immune evasion. Moreover, this information may lead to the identification of novel biomarkers for more precise patient stratification and therapy guidance.

scholarly journals Feasibility of Fecal MicroRNAs as Novel Biomarkers for Pancreatic Cancer

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e42933 ◽  
Author(s):  
Alexander Link ◽  
Verena Becker ◽  
Ajay Goel ◽  
Thomas Wex ◽  
Peter Malfertheiner
Keyword(s):  
Pancreatic Cancer ◽  
Novel Biomarkers

Circulating exosomal microRNAs as novel detection biomarkers in pancreatic cancer

2020 ◽  
Author(s):  
Lun Wu(Former Corresponding Author) ◽  
Wen-Bo Zhou ◽  
Jiao Zhou ◽  
Ying Wei ◽  
Hong-Mei Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Rna Isolation ◽  
Serum Levels ◽  
Tumor Stage ◽  
Serum Samples ◽  
Expression Levels ◽  
Transmission Electron ◽  
Significant Difference ◽  
Novel Biomarkers ◽  
Exosomal Mirna

Abstract Background Circulating exosomal microRNAs are reflective of the characteristics of the tumor, are valuable biomarkers in different types of tumors, and play important roles in tumor progression and metastasis. The purpose of this study was to investigate the circulating exosomal microRNAs miRNA-21 and miRNA-210 as novel biomarkers for patients with pancreatic cancer (PC).Methods Serum exosomal microRNAs were extracted from the serum of PC and chronic pancreatitis (CP) patients using an RNA Isolation kit. To identify the exosomes in the serum, we used transmission electron micrographs for the crystalline structure, western blotting, and NanoSight for exosomal markers and nanoparticle characterization. The relative expression levels of exosomal microRNAs were quantified using quantitative PCR and compared between PC and CP patients.Results A total of 40 serum samples (30 PC and 10 CP) were collected. The expression levels of both exosomal miRNA-21 and miRNA-210 were obviously higher in PC patients compared with those in CP patients (both P<0.001). However, no significant difference in the relative serum levels of free miR-21 and miR-210 was observed between these two groups (both P>0.05). Exosomal miRNA-21 and miRNA-210 were related to tumor stage, as well as other factors. The diagnostic of exosomal miRNA-21 and miRNA-210 levels was 83% and 85%, respectively. Furthermore, when combining the expression of exosomal miRNA with serum CA19-9, the accuracy increased to 90%.Conclusions We herein identified that the serum exosomal miRNAs miRNA-21 and miRNA-210 may be of value as potential biomarkers and therapeutic targets for the diagnosis and treatment of PC.

scholarly journals LncRNA co-expression network analysis reveals novel biomarkers for pancreatic cancer

2018 ◽  
Vol 39 (8) ◽  
pp. 1016-1025 ◽  
Author(s):  
Matteo Giulietti ◽  
Alessandra Righetti ◽  
Giovanni Principato ◽  
Francesco Piva
Keyword(s):  
Pancreatic Cancer ◽  
Network Analysis ◽  
Novel Biomarkers

scholarly journals LncRNAs: Novel Biomarkers for Pancreatic Cancer

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1665
Author(s):  
Soudeh Ghafouri-Fard ◽  
Mohadeseh Fathi ◽  
Tianyue Zhai ◽  
Mohammad Taheri ◽  
Peixin Dong
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
Early Detection Of Cancer ◽  
The Other ◽  
Current Review ◽  
Novel Biomarkers ◽  
Males And Females ◽  
Non Coding Rnas ◽  
Prognostic Prediction ◽  
Low Expression

Pancreatic cancer is one of the most deadly neoplasms and the seventh major cause of cancer-related deaths among both males and females. This cancer has a poor prognosis due to the lack of appropriate methods for early detection of cancer. Long non-coding RNAs (lncRNAs) have been recently found to influence the progression and initiation of pancreatic cancer. MACC1-AS1, LINC00976, LINC00462, LINC01559, HOXA-AS2, LINC00152, TP73-AS1, XIST, SNHG12, LUCAT1, and UCA1 are among the oncogenic lncRNAs in pancreatic cancer. On the other hand, LINC01111, LINC01963, DGCR5, MEG3, GAS5, and LINC00261 are among tumor suppressor lncRNAs in this tissue. In the current review, we summarize the roles of these two classes of lncRNAs in pancreatic cancer and discuss their potential as attractive diagnostic and prognostic biomarkers for pancreatic cancer. We also identified that the low expression of MEG3, LINC01963, and LINC00261 and the high expression of MACC1-AS1, LINC00462, LINC01559, and UCA1 were significantly correlated with worse survival in pancreatic cancer patients. Further research on these lncRNAs will provide new clues that could potentially improve the early diagnosis, prognostic prediction, and personalized treatments of patients with pancreatic cancer.

MicroRNAs as novel biomarkers for pancreatic cancer diagnosis: a meta-analysis based on 18 articles

Tumor Biology ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. 8837-8848 ◽  
Author(s):  
Zhongyang Ding ◽  
Haorong Wu ◽  
Jiaming Zhang ◽  
Guorong Huang ◽  
Dongdong Ji
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
Novel Biomarkers

PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression

2020 ◽  
Vol 1864 (11) ◽  
pp. 129682
Author(s):  
Sumit Sahni ◽  
Christoph Krisp ◽  
Mark P. Molloy ◽  
Christopher Nahm ◽  
Sarah Maloney ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Novel Biomarkers
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