scholarly journals Current State of the PET/CT Hybrid Technique and Clinical Indications

10.5772/28834 ◽  
2011 ◽  
Author(s):  
Patricia Carreno-Moran ◽  
Maria de las Nieves Gomez Leo
2015 ◽  
Vol 173 (3) ◽  
pp. R115-R130 ◽  
Author(s):  
Massimo Salvatori ◽  
Bernadette Biondi ◽  
Vittoria Rufini

In recent years, 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG-PET/CT plays in clinical practice is that it can be used to obtain prognostic information in patients with increasing thyroglobulin (Tg) levels and negative 131I whole-body scan post-thyroidectomy and radioiodine (RAI) ablation. FDG-PET/CT may also have a potential role in the initial staging and follow-up of high-risk patients with aggressive histological subtypes, in the identification of patients who are at the highest risk of disease-specific mortality, in the management of patients with RAI-refractory disease, in clinical trials of novel targeted therapies in patients with advanced metastatic disease, and in the evaluation of thyroid nodules with indeterminate fine-needle aspiration for cytology. However, several controversies remain to be resolved, namely: the cutoff value of Tg in the selection of DTC patients for FDG-PET/CT, whether FDG-PET/CT scanning should be performed under thyrotropin stimulation or suppression, and the clinical significance of thyroid FDG-PET/CT incidentalomas. The aim of the present article is to provide an overview of the data about the molecular basis for, clinical indications of, and controversies related to the use of FDG-PET/CT in patients with DTC.


1984 ◽  
Vol 6 (4) ◽  
pp. 349-395 ◽  
Author(s):  
J. Ophir ◽  
T. H. Shawker ◽  
N. F. Maklad ◽  
J. G. Miller ◽  
S. W. Flax ◽  
...  

This monograph presents a tutorial review of the current state-of-the-art in ultrasonic attenuation estimation in reflection. Clinical indications which provide the motivation for attempting in vivo attenuation estimation are discussed. Frequency and time domain techniques and their respective tradeoffs and problems are presented. Finally, current clinical results obtained with the various techniques are summarized and further areas of study are suggested.


2016 ◽  
Vol 58 (5) ◽  
pp. 737-743 ◽  
Author(s):  
Mehdi Taghipour ◽  
Charles Marcus ◽  
Sara Sheikhbahaei ◽  
Esther Mena ◽  
Shwetha Prasad ◽  
...  

2010 ◽  
Vol 24 (3) ◽  
pp. 207-214 ◽  
Author(s):  
A. M. García Vicente ◽  
A. M. Soriano Castrejón ◽  
M. P. Talavera Rubio ◽  
A. A. León Martín ◽  
A. M. Palomar Muñoz ◽  
...  

Author(s):  
Chukwuka Eze ◽  
Nina-Sophie Schmidt-Hegemann ◽  
Lino Morris Sawicki ◽  
Julian Kirchner ◽  
Olarn Roengvoraphoj ◽  
...  

Abstract Purpose The advent of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced NSCLC, leading to a string of approvals in recent years. Herein, a narrative review on the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in the ever-evolving treatment landscape of advanced NSCLC is presented. Methods This comprehensive review will begin with an introduction into current treatment paradigms incorporating ICIs; the evolution of CT-based criteria; moving onto novel phenomena observed with ICIs and the current state of hybrid imaging for diagnosis, treatment planning, evaluation of treatment efficacy and toxicity in advanced NSCLC, also taking into consideration its limitations and future directions. Conclusions The advent of ICIs marks the dawn of a new era bringing forth new challenges particularly vis-à-vis treatment response assessment and observation of novel phenomena accompanied by novel systemic side effects. While FDG PET/CT is widely adopted for tumor volume delineation in locally advanced disease, response assessment to immunotherapy based on current criteria is of high clinical value but has its inherent limitations. In recent years, modifications of established (PET)/CT criteria have been proposed to provide more refined approaches towards response evaluation. Not only a comprehensive inclusion of PET-based response criteria in prospective randomized controlled trials, but also a general harmonization within the variety of PET-based response criteria is pertinent to strengthen clinical implementation and widespread use of hybrid imaging for response assessment in NSCLC.


Author(s):  
Vinothini Ramasamy Vellalapalayam ◽  
Thangaraj Ponnusamy ◽  
Sakthisudhan Karuppanan

Background: One of the primary causes of sleep disorders, depth of anesthesia, coma, encephalopathy’s and brain death in the world is epilepsy. EEG is most often used to diagnose epilepsy which causes the abnormalities in EEG readings. Different high-resolution anatomical imaging techniques are used to detect these abnormalities like MRI, PET, CT, etc. Methods: SWT method will be an enhanced system from wavelet transform. It may be fit for the signal for time-invariant on the break down also enhance those force of indicator denoising. SWT additionally employs upsampled technique at every level of decay for those signs. The decay of SWT produces the coefficients from claiming close estimation and points in the same length. : The DWT will be actualized by a channel bank that decomposes those indicators over progressive coarser approximations. The output of the low pass and high pass filter coefficients is decomposed to the next level and further proceeds up to N levels. The yield of the wavelet decay may be that close estimation and the point of interest coefficients which would get to each level of decay. This system consists of five main processing steps: acquisition, pre-processing, feature extraction, feature selection and classification. Results: This paper overviews some of the current state-of-the-art IOT systems and presents the statistical-based algorithm used for each processing step. Conclusion: This paper also provides a comparison of the performance of the existing approaches.


Author(s):  
G.D. Danilatos

Over recent years a new type of electron microscope - the environmental scanning electron microscope (ESEM) - has been developed for the examination of specimen surfaces in the presence of gases. A detailed series of reports on the system has appeared elsewhere. A review summary of the current state and potential of the system is presented here.The gas composition, temperature and pressure can be varied in the specimen chamber of the ESEM. With air, the pressure can be up to one atmosphere (about 1000 mbar). Environments with fully saturated water vapor only at room temperature (20-30 mbar) can be easily maintained whilst liquid water or other solutions, together with uncoated specimens, can be imaged routinely during various applications.


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