scholarly journals The Potential Use of Triterpene Compounds in Dendritic Cells-Based Immunotherapy

10.5772/28764 ◽  
2012 ◽  
Author(s):  
Masao Takei ◽  
Akemi Umeyama ◽  
Je-Jung Lee
Keyword(s):  
Dendritic Cells ◽  
Potential Use

scholarly journals In Vivo Transduction of Thymic Dendritic Cells with Adenovirus and Its Potential Use in Acute Inflammatory Diseases

2005 ◽  
Vol 61 (4) ◽  
pp. 309-315 ◽  
Author(s):  
C. Oberholzer ◽  
S. K. Tschoeke ◽  
K. Bahjat ◽  
D. LaFace ◽  
B. Hutchins ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Inflammatory Diseases ◽  
Potential Use

RNA-loaded dendritic cells: more than a tour de force in cancer therapeutics

Immunotherapy ◽  
2019 ◽  
Vol 11 (13) ◽  
pp. 1129-1147
Author(s):  
Aishwarya Joshi ◽  
Nikunj Tandel ◽  
Priyanka Tyagi ◽  
Sarat K Dalai ◽  
Prakash S Bisen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Conventional Treatment ◽  
Treatment Options ◽  
Cancer Therapeutics ◽  
Therapeutic Strategies ◽  
Vital Role ◽  
Delivery Vehicles ◽  
Immune Competency ◽  
Potential Use

A wide array of therapeutic strategies has been implemented against cancers, yet their clinical benefit is limited. The lack of clinical efficacy of the conventional treatment options might be due to the inept immune competency of the patients. Dendritic cells (DCs) have a vital role in initiating and directing immune responses and have been frequently used as delivery vehicles in clinical research. The recent clinical data suggest the potential use of DCs pulsed with nucleic acid, especially with RNA holds a great potential as an immunotherapeutic measure with compare to other cancer therapeutics. This review mainly deals with the DCs and their role in transfection with RNA in cancer immunotherapy.

scholarly journals Immunogenic ferroptosis and where to find it?

2021 ◽  
Vol 9 (12) ◽  
pp. e003430
Author(s):  
Robin Demuynck ◽  
Iuliia Efimova ◽  
Faye Naessens ◽  
Dmitri V Krysko
Keyword(s):  
Cell Death ◽  
Dendritic Cells ◽  
Cancer Cells ◽  
Antitumor Immunity ◽  
Anticancer Therapy ◽  
Oxidized Lipids ◽  
Immunogenic Cell Death ◽  
Cross Presentation ◽  
Regulated Cell Death ◽  
Potential Use

Ferroptosis is a recently discovered form of regulated cell death that is morphologically, genetically, and biochemically distinct from apoptosis and necroptosis, and its potential use in anticancer therapy is emerging. The strong immunogenicity of (early) ferroptotic cancer cells broadens the current concept of immunogenic cell death and opens up new possibilities for cancer treatment. In particular, induction of immunogenic ferroptosis could be beneficial for patients with cancers resistant to apoptosis and necroptosis. However, ferroptotic cancer cells may be a rich source of oxidized lipids, which contribute to decreased phagocytosis and antigen cross-presentation by dendritic cells and thus may favor tumor evasion. This could explain the non-immunogenicity of late ferroptotic cells. Besides the presence of lactate in the tumor microenvironment, acidification and hypoxia are essential factors promoting ferroptosis resistance and affecting its immunogenicity. Here, we critically discuss the crucial mediators controlling the immunogenicity of ferroptosis that modulate the induction of antitumor immunity. We emphasize that it will be necessary to also identify the tolerogenic (ie, immunosuppressive) nature of ferroptosis, which can lead to tumor evasion.

The biology of dendritic cells and their potential use in veterinary medicine

2003 ◽  
Vol 4 (2) ◽  
pp. 131-142 ◽  
Author(s):  
D. E. Jones ◽  
D. E. Jones ◽  
Y. Vanloubbeeck ◽  
J. Hostetter ◽  
D. E. Jones
Keyword(s):  
Dendritic Cells ◽  
Veterinary Medicine ◽  
Potential Use

Potential Use of Dendritic Cells for Anti-Atherosclerotic Therapy

2013 ◽  
Vol 19 (33) ◽  
pp. 5873-5882 ◽  
Author(s):  
Ilse Brussel ◽  
Dorien Schrijvers ◽  
Emily Vré ◽  
Hidde Bult
Keyword(s):  
Dendritic Cells ◽  
Potential Use

scholarly journals Dendritic cells in the skin - potential use for melanoma treatment

2009 ◽  
Vol 22 (1) ◽  
pp. 30-41 ◽  
Author(s):  
Sanaa El Marsafy ◽  
Martine Bagot ◽  
Armand Bensussan ◽  
Alain Mauviel
Keyword(s):  
Dendritic Cells ◽  
Skin Potential ◽  
Melanoma Treatment ◽  
Potential Use
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