scholarly journals TRP-Channels and Human Prostate Carcinogenesis

10.5772/28748 ◽  
2011 ◽  
Author(s):  
Vyacheslav Lehenkyi ◽  
Natalia Prevarskay
Keyword(s):  
Trp Channels ◽  
Human Prostate ◽  
Prostate Carcinogenesis

scholarly journals TRP Channels in Human Prostate

2010 ◽  
Vol 10 ◽  
pp. 1597-1611 ◽  
Author(s):  
Carl Van Haute ◽  
Dirk De Ridder ◽  
Bernd Nilius
Keyword(s):  
Prostate Cancer ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Current Knowledge ◽  
Receptor Potential ◽  
Human Prostate ◽  
Prostate Carcinogenesis ◽  
Potential Impact ◽  
Transient Receptor ◽  
Prostate Diseases

This review gives an overview of morphological and functional characteristics in the human prostate. It will focus on the current knowledge about transient receptor potential (TRP) channels expressed in the human prostate, and their putative role in normal physiology and prostate carcinogenesis. Controversial data regarding the expression pattern and the potential impact of TRP channels in prostate function, and their involvement in prostate cancer and other prostate diseases, will be discussed.

Characterisation of intermediate cells in the human prostate epithelium: implications for prostate carcinogenesis and treatment

2002 ◽  
Vol 1 (1) ◽  
pp. 30
Author(s):  
Peter Mulders ◽  
Geert van Leenders ◽  
Bianca Ory ◽  
Tilly Aalders ◽  
Frans Debruyne ◽  
...  
Keyword(s):  
Human Prostate ◽  
Prostate Carcinogenesis ◽  
Intermediate Cells ◽  
Prostate Epithelium

ID: 82: DISTINCT ACTIONS OF ERα AND ERβ IN HUMAN PROSTATE STEM AND PROGENITOR CELL SELF-RENEWAL AND DIFFERENTIATION

2016 ◽  
Vol 64 (4) ◽  
pp. 928.1-928 ◽  
Author(s):  
D Hu ◽  
W Hu ◽  
S Majumdar ◽  
T Gauntner ◽  
Y Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Side Population ◽  
Population Analysis ◽  
Human Prostate ◽  
Mrna Levels ◽  
Self Renewal ◽  
Prostate Carcinogenesis ◽  
Prostate Epithelial Cells

Estrogens are implicated in prostate development and cancer, while stem cells are essential in tissue homeostasis and carcinogenesis. We have previously demonstrated that estradiol-17β (E2) treatment augments prostaspheres (PS) number and size, implicating them as direct estrogen targets. The present studies sought to elucidate specific roles for ERα and ERβ in prostate stem and progenitor cells.Prostate stem-progenitor cells were identified and isolated from normal primary prostate epithelial cells (PrEC) using long term BrdU retention in 3-D PS culture. FACS analyses (BrdU/ERα or ERβ) showed prostate stem and progenitor populations were both ERα+ and ERβ+. BrdU-retaining stem cells expressed high levels of ERβ and lower ERα as compared to non-label-retaining progenitor cells, suggesting ERβ dominance in the prostate stem cell. Estradiol increased BrdU-retaining cell numbers by enhancing stem cell self-renewal through symmetric division. While ERα siRNA blocked the E2-stimulated BrdU-retaining cells, ERβ knockdown augmented the E2-induced increase of BrdU-retaining cells. Together these findings suggest that ERα stimulates whereas ERβ suppresses stem cell self-renew. This conclusion is supported by separate studies on 2-D cultured PrEC with FACS stem-like cell side-population analysis using selective ER antagonists and siRNA. Although ERβ siRNA did not influence ERα mRNA levels, ERα siRNA doubled ERβ expression suggesting a suppressive role of ERα on ERβ action.In total, the present findings identify distinct localization patterns and roles for ERα and ERβ in human prostate stem-like and daughter progenitor cells with ERα driving self-renewal and ERβ braking division. We propose that a delicate balance between ERα and ERβ contributes to prostate stem cell niche homeostasis and that their dysregulation may contribute to prostate carcinogenesis and progression.

Intercellular Communication and Human Prostate Carcinogenesis

2006 ◽  
Vol 963 (1) ◽  
pp. 156-168 ◽  
Author(s):  
GIUSEPPE CARRUBA ◽  
ROSALBA STEFANO ◽  
LETIZIA COCCIADIFERRO ◽  
FRANCESCA SALADINO ◽  
ANTONIETTA CRISTINA ◽  
...  
Keyword(s):  
Intercellular Communication ◽  
Human Prostate ◽  
Prostate Carcinogenesis

scholarly journals BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

Oncogene ◽  
2019 ◽  
Vol 39 (8) ◽  
pp. 1797-1806 ◽  
Author(s):  
Carolyn J. Loveridge ◽  
Sarah Slater ◽  
Kirsteen J. Campbell ◽  
Noor A. Nam ◽  
John Knight ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Rna Polymerase Iii ◽  
Adaptive Immune Response ◽  
Human Prostate ◽  
Limiting Factor ◽  
Complement Factor ◽  
Human Prostate Cancer ◽  
Prostate Carcinogenesis ◽  
Immune Pathway

AbstractBRF1 is a rate-limiting factor for RNA Polymerase III-mediated transcription and is elevated in numerous cancers. Here, we report that elevated levels of BRF1 associate with poor prognosis in human prostate cancer. In vitro studies in human prostate cancer cell lines demonstrated that transient overexpression of BRF1 increased cell proliferation whereas the transient downregulation of BRF1 reduced proliferation and mediated cell cycle arrest. Consistent with our clinical observations, BRF1 overexpression in a Pten-deficient mouse (PtenΔ/ΔBRF1Tg) prostate cancer model accelerated prostate carcinogenesis and shortened survival. In PtenΔ/ΔBRF1Tg tumours, immune and inflammatory processes were altered, with reduced tumoral infiltration of neutrophils and CD4 positive T cells, which can be explained by decreased levels of complement factor D (CFD) and C7 components of the complement cascade, an innate immune pathway that influences the adaptive immune response. We tested if the secretome was involved in BRF1-driven tumorigenesis. Unbiased proteomic analysis on BRF1-overexpresing PC3 cells confirmed reduced levels of CFD in the secretome, implicating the complement system in prostate carcinogenesis. We further identify that expression of C7 significantly correlates with expression of CD4 and has the potential to alter clinical outcome in human prostate cancer, where low levels of C7 associate with poorer prognosis.

Abstract 1328: Cadmium-induced endoplasmic reticulum stress causes defective autophagy in human prostate carcinogenesis

2018 ◽  
Author(s):  
Venkatesh Kolluru ◽  
Ashish Tyagi ◽  
Balaji Chandrasekaran ◽  
Murali K. Ankem ◽  
Chendil Damodaran
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Human Prostate ◽  
Prostate Carcinogenesis
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