scholarly journals Free Radicals in Neurodegenerative Diseases: Modulation by Palladium α-Lipoic Acid Complex

10.5772/28706 ◽  
2011 ◽  
Author(s):  
Chirakkal V. ◽  
Merrill Garnett ◽  
Frank Antonawich
Keyword(s):  
Free Radicals ◽  
Neurodegenerative Diseases ◽  
Lipoic Acid ◽  
Acid Complex

scholarly journals Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid

2021 ◽  
Vol 22 (1) ◽  
pp. 403
Author(s):  
Fanni Tóth ◽  
Edina Katalin Cseh ◽  
László Vécsei
Keyword(s):  
Neurodegenerative Diseases ◽  
Lipoic Acid ◽  
Kynurenic Acid ◽  
Biological Activities ◽  
Neuroprotective Effect ◽  
Structural Diversity ◽  
Kynurenine Pathway ◽  
Glutamate Excitotoxicity ◽  
Neuroprotective Agents ◽  
Starting Point

The incidence of neurodegenerative diseases has increased greatly worldwide due to the rise in life expectancy. In spite of notable development in the understanding of these disorders, there has been limited success in the development of neuroprotective agents that can slow the progression of the disease and prevent neuronal death. Some natural products and molecules are very promising neuroprotective agents because of their structural diversity and wide variety of biological activities. In addition to their neuroprotective effect, they are known for their antioxidant, anti-inflammatory and antiapoptotic effects and often serve as a starting point for drug discovery. In this review, the following natural molecules are discussed: firstly, kynurenic acid, the main neuroprotective agent formed via the kynurenine pathway of tryptophan metabolism, as it is known mainly for its role in glutamate excitotoxicity, secondly, the dietary supplement pantethine, that is many sided, well tolerated and safe, and the third molecule, α-lipoic acid is a universal antioxidant. As a conclusion, because of their beneficial properties, these molecules are potential candidates for neuroprotective therapies suitable in managing neurodegenerative diseases.

Levantamento da Utilização do Pequi (Caryocar brasiliense camb.) como Agente Antioxidante na Prevenção de Doenças Neurodegenerativas

UNICIÊNCIAS ◽  
2017 ◽  
Vol 21 (2) ◽  
pp. 110
Author(s):  
Erick De Oliveira Lemes ◽  
Michele Maria Carlos Fernandes ◽  
Valeria Paiva Rosa ◽  
Adriano Honorato Nascimento
Keyword(s):  
Free Radicals ◽  
Neurodegenerative Diseases ◽  
Public Health Problem ◽  
Human Organism ◽  
Loss Of Function ◽  
Neuronal Structure ◽  
Fruit Species ◽  
Antioxidant Agent ◽  
Caryocar Brasiliense ◽  
Best Fit

O cerrado é um patrimônio de recursos naturais renováveis, com espécies frutíferas, com características peculiares e intensas. O Caryocar brasiliense Camb. possui atividade antioxidante, conforme estudos realizados, o consumo de pequi regularmente pode agir de forma a minimizar esse desequilíbrio, com a diminuição do nível de radicais livres no organismo humano. As doenças neurodegenerativas levam à perda de função e estrutura neuronal, sendo um grave problema de saúde pública, o número de casos cresce a cada ano. Estas doenças são associadas ao desequilíbrio entre a produção de radicais livres e antioxidantes. O presente estudo teve a finalidade de discutir sobre a importância da utilização do Caryocar brasiliense camb. como agente antioxidante, que pode ser utilizado na prevenção da doença de Alzheimer e doença de Parkinson, caracterizadas como doenças neurodegenerativas. Esta investigação foi caracterizada como pesquisa bibliográfica, a coleta foi realizada nas bases eletrônicas, para avaliação inicial foi realizada leitura dos resumos, com finalidade de selecionar aqueles que melhor se adequaram ao objetivo da pesquisa. A utilização do Caryocar brasiliense Camb. na alimentação é benéfico para a população, de uma forma geral, por apresentar ação antioxidante, o que diminui os danos oxidativos, podendo retardar o envelhecimento precoce das células e evitar o desenvolvimento das doenças neurodegenerativas.Palavras-chave: População. Antioxidante. Doenças neurodenerativas.AbstractThe cerrado is a heritage of renewable natural resources, with fruit species, with peculiar and intense characteristics. The Caryocar brasiliense Camb., has antioxidant activity, according to studies carried out, the consumption of pequi regularly can act in a way to minimize this imbalance, with the reduction of the level of free radicals in the human organism. Neurodegenerative diseases, leads to loss of function and neuronal structure, is a serious public health problem and the number of cases grows each year. These are associated with the imbalance between the production of free radicals and antioxidants. The present study had the purpose of discussing the importance of the use of Caryocar brasiliense camb., as an antioxidant agent that can be used in the prevention of Alzheimer’s disease and Parkinson’s disease, characterized as neurodegenerative diseases. This research was characterized as a bibliographical research, the collection was performed in the electronic databases, for the initial evaluation, the abstracts were read, with the purpose of selecting those that best fit the research objective. The use of Caryocar brasiliense Camb in dietes is beneficial to the population in general, because it has antioxidant action, which decreases oxidative damage, can delay the early cells aging and prevent the neurodegenerative diseases development.Keywords: Population. Antioxidant. Neurodegenerative diseases.

scholarly journals Alpha Lipoic Acid: A Therapeutic Strategy that Tend to Limit the Action of Free Radicals in Transplantation

2018 ◽  
Vol 19 (1) ◽  
pp. 102 ◽  
Author(s):  
Nella Ambrosi ◽  
Diego Guerrieri ◽  
Fiorella Caro ◽  
Francisco Sanchez ◽  
Geraldine Haeublein ◽  
...  
Keyword(s):  
Free Radicals ◽  
Lipoic Acid ◽  
Therapeutic Strategy ◽  
Alpha Lipoic Acid

scholarly journals Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model

2017 ◽  
Vol 187 (3) ◽  
pp. 361 ◽  
Author(s):  
Vijayalakshmi Sridharan ◽  
John W. Seawright ◽  
Francis J. Antonawich ◽  
Merrill Garnett ◽  
Maohua Cao ◽  
...  
Keyword(s):  
Heart Disease ◽  
Lipoic Acid ◽  
Rat Model ◽  
Cardiac Mitochondria ◽  
Acid Complex ◽  
Radiation Induced

Palladium-α-lipoic acid complex attenuates alloxan-induced hyperglycemia and enhances the declined blood antioxidant status in diabetic rats

2011 ◽  
Vol 3 (4) ◽  
pp. 293-300 ◽  
Author(s):  
Narayana P. SUDHEESH ◽  
Thekuttuparambil A. AJITH ◽  
Kainoor K. JANARDHANAN ◽  
Chirakkal V. KRISHNAN
Keyword(s):  
Lipoic Acid ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Acid Complex

Protective role of DLa-lipoic acid against adriamycin-induced cardiac lipid peroxidation

2003 ◽  
Vol 22 (5) ◽  
pp. 249-254 ◽  
Author(s):  
A V Balachandar ◽  
K P Malarkodi ◽  
P Varalakshmi
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Lipoic Acid ◽  
Antioxidant Property ◽  
Protective Role ◽  
Cytoprotective Activity ◽  
Male Wistar Rats ◽  
Cellular Defence ◽  
Antitumour Drug

The cytoprotective activity of a-lipoic acid against free radical toxicity manifested during adriamycin (ADR)induced cardiotoxicity has been investigated. ADR is a potent antitumour drug known to cause severe cardiotoxicity. Although ADR generates free radicals, the role of these radicals in the development of cardiac toxicity is still not well understood. In the present study, we evaluated the influence of chronic ADR treatment on the cellular defence mechanism against free radicals and the effect of a-lipoic acid supplementation on ADR-induced cardiotoxicity in male Wistar rats. The increase in lipid peroxidation (LPO) and activities of serum myocardial enzymes, namely lactate dehydrogenase (LDH) and creatinephosphokinase, associated with the decrease in activities of enzymatic (SOD, CAT, GPx, G6PD and GR) and non-enzymatic (GSH, Vit C and Vit E) antioxidants levels were the salient features observed in ADR-induced cardiotoxicity. Lipoic acid pretreated groups showed significant increase in activities of both enzymatic and non-enzymatic antioxidant levels. These observations highlight the antioxidant property ofa-lipoic acid and its cytoprotective action against ADR-induced cardiotoxicity.

scholarly journals Role of Free Radicals, Glutamate Toxicity, Glutathione Depletion in Apoptosis of Cochlear Hair Cells, Neuronal Cells among Patients with Sensorineural Hearing Loss

2020 ◽  
Vol 3 (02) ◽  
pp. 047-056
Author(s):  
Vithal D. Udagatti ◽  
Rajendran Dinesh Kumar ◽  
Arjunsing Vijaysing Samorekar ◽  
Vaibhavi KR
Keyword(s):  
Hearing Loss ◽  
Free Radicals ◽  
Sensorineural Hearing Loss ◽  
Lipoic Acid ◽  
Cell Damage ◽  
Sensorineural Hearing ◽  
Glutathione Depletion ◽  
Glutamate Toxicity ◽  
Alpha Lipoic Acid ◽  
Total Period

Abstract Introduction Hearing loss may lead to depression, decreased quality of life, reduced functional status and social isolation. The glutathione-S transferase (GSTS) is an antioxidant scavenging enzyme. Decreased glutathione and GSTS activity levels lead to an increase in susceptibility of hair-cell damage leading to sensorineural hearing loss. The cumulative effect of oxidative stress and mitochondrial damage by free radicals results in the mutation/deletion of deoxyribonucleic acid, leading to decline in mitochondrial function, which in turn plays an important role in inducing apoptosis of the cochlear cells. Other risk factors also include noise exposure, genetic predisposition, health comorbidities, ototoxic drugs, infections, and immune-mediated inflammation of auditory cells. Study Design Prospective, non-comparative, metacentric clinical study. Materials and Methods The study was carried out in 30 patients from 6/5/2016 to 10/1/2018. Total of 30 patients of sensorineural hearing loss were enrolled (17 males, 13 females). Clinical history, ENT examination, and audiogram were done, treatment duration of 8 weeks for each patient and followed up to 3 outpatient visits. The patient was administered rebamipide 100 mg, alpha lipoic acid 100 mg, and acetylcysteine 100 mg capsules twice a day for a total period of 8 weeks. Wherever giddiness was an added symptom, Cinnarizine 20mg with Diaminehydrate 40 mg combination twice a day was added up to complete relief of symptoms, thereafter once a day as maintenance dose over a period of 8 weeks. Wherever tinnitus was an added symptom, deflazacort 6 mg twice a day was added and tapered up to 1 month. If the symptom of tinnitus persisted, intratympanic steroid injection was given. During every visit, clinical assessment and audiogram were repeated. Results Our study demonstrated greater improvement in hearing at higher frequencies with 8 weeks of rebamipide 100 mg + alpha lipoic acid 100 mg + acetylcysteine 100 mg administration in 30 patients with twice-daily dosing. Conclusion Synthesis of free radicals in the inner ear may play an important part in the pathogenesis of sensory hearing loss. The combination of rebamipide 100 mg + alpha lipoic acid 100 mg + acetylcysteine 100 mg is effective prophylaxis in sensorineural hearing loss that addresses both factors of inhibiting the cochlear cell damage and enhancing cochlear cell preservation.

Association of Oxidative Stress with Neurological Disorders

2021 ◽  
Vol 19 ◽  
Author(s):  
Waseem Hassan ◽  
Hamsa Noreen ◽  
Shakila Rehman ◽  
Mohammad Amjad Kamal ◽  
Joao Batista Teixeira da Rocha
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Neurodegenerative Diseases ◽  
Neurological Disorders ◽  
Biological Effects ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Neuronal Membranes

Background: Oxidative stress is one of the main contributing factors involved in cerebral biochemical impairment. The higher susceptibility of the central nervous system to reactive oxygen species mediated damage could be attributed to several factors. For example, neurons use a greater quantity of oxygen, many parts of the brain have higher concentraton of iron, and neuronal mitochondria produce huge content of hydrogen peroxide. In addition, neuronal membranes have polyunsaturated fatty acids, which are predominantly vulnerable to oxidative stress (OS). OS is the imbalance between reactive oxygen species generation and cellular antioxidant potential. This may lead to various pathological conditions and diseases, especially neurodegenerative diseases such as, Parkinson’s, Alzheimer’s, and Huntington’s diseases. Objectives: In this study, we explored the involvement of OS in neurodegenerative diseases. Methods: We used different search terms like “oxidative stress and neurological disorders” “free radicals and neurodegenerative disorders” “oxidative stress, free radicals, and neurological disorders” and “association of oxidative stress with the name of disorders taken from the list of neurological disorders. We tried to summarize the source, biological effects, and physiologic functions of ROS. Results: Finally, it was noted that more than 190 neurological disorders are associated with oxidative stress.

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