scholarly journals Antihypertensive Peptides Specific to Lactobacillus helveticus Fermented Milk

Author(s):  
Taketo Wakai ◽  
Naoyuki Yamamoto
2012 ◽  
Vol 114 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Taketo Wakai ◽  
Naoya Yamaguchi ◽  
Misaki Hatanaka ◽  
Yasunori Nakamura ◽  
Naoyuki Yamamoto

Life Sciences ◽  
2013 ◽  
Vol 93 (25-26) ◽  
pp. e43
Author(s):  
Hsiao-Ling Chen ◽  
Yu-Tang Tung ◽  
Geroge Kuo ◽  
Chuan-Mu Chen

Life Sciences ◽  
2004 ◽  
Vol 75 (14) ◽  
pp. 1727-1734 ◽  
Author(s):  
Mirkka Narva ◽  
Jussi Halleen ◽  
Kalervo Väänänen ◽  
Riitta Korpela

2005 ◽  
Vol 24 (4_suppl) ◽  
pp. 91-96 ◽  
Author(s):  
Keiichi Matsuura ◽  
John H. Mennear ◽  
Masafumi Maeno ◽  
Bruce K. Bernard

The objective of these in vivo experiments was to assess the mutagenic potential of tripeptides as reflected by the ability of the test compound to induce the formation of micronuclei in mouse polychromatic erythrocytes. The test agents used in these experiments were (1) powdered Aspergillus oryzae protease casein hydrolysate (CH) and (2) powdered Lactobacillus helveticus-fermented milk (FM). Both test agents contain two tripeptides, L-valyl-L-prolyl-L-proline (VPP) and L-isoleucyl-L-prolyl-L-proline (IPP). Male Sprague-Dawley rats (five per group) were administered doses of 0, 500, 1000, or 2000 mg (0, 3, 6, or 12 mg VPP plus IPP)/kg body weight (BW)/day CH by oral gavage for 2 days. Male CD-I mice (six per group) received a single oral gavage dose of 0, 500, 1000, or 2000 mg (0, 0.8, 1.6 or 3.3 mg VPP plus IPP)/kg BW of FM. Positive-control agents were cyclophosphamide (10 mg/kg, intraperitoneal [i.p.]) in rats and mitocycin C (2 mg/kg, i.p.) in mice. Twenty-four hours after the second dose of CH, or the dose of cyclophosphamide to rats, or FM or mitocycin C to mice, bone marrow cells were fixed and examined for the presence of polychromatic erythrocytes (PCEs) and the presence or absence of mi-cronucleated PCEs (MNPCEs). Administration of CH to rats and FM to mice produced neither changes in body weights nor signs of systemic toxicity. Similarly, neither CH nor FM caused statistically significant variations in the incidences of either PCEs or MNPCEs. Both positive-control agents caused unequivocal increases in the incidence of MNPCEs and cyclophosphamide significantly reduced the percent of rat erythrocytes appearing as PCEs. The results of these micronucleus assays conducted with either powdered CH or FM in rats and mice, respectively, show that neither form of the tripeptides possesses the potential to induce micronuclei formation in these rodent species.


1988 ◽  
Vol 41 (4) ◽  
pp. 324-327
Author(s):  
Terumi HIRABAYASHI ◽  
Kazuyoshi SATO ◽  
Takuji SASAKI

2019 ◽  
Vol 49 (2) ◽  
pp. 249-261 ◽  
Author(s):  
Marli Busanello ◽  
Marsilvio Lima De Moraes Filho ◽  
Karla Bigetti Guergoletto ◽  
Sandra Garcia

Purpose This paper aims to study the effect of addition of green banana flour (GBF) in skim milk, provides a nutritional and functional contribution to this matrix when added. They have biological compounds like resistant starch, phenolic compounds, antioxidant compounds and others. The skim milk containing 1.08 per cent of GBF was chosen after a central composite rotational design and response surface methodology. The response variable was the growth of Lactobacillus plantarum (LP) and Lactobacillus helveticus (LH). Design/methodology/approach During the fermentation process, the antioxidant activity, plasmid DNA protection capacity, proteolytic activity and inhibitory activity of angiotensin-converting enzyme (ACE) of the fermented milk was determined. Findings All variables were influenced by the fermentation time. The antioxidant activity evaluated by the ABTS radical presented values of 0.83 ± 0.04 µM Trolox.mL−1 and 0.79 ± 0.02 µM Trolox.mL−1, respectively, for the fermented LP and LH. The extracts fermented by L. plantarum and L. helveticus were able to inhibit the oxidation of plasmidial DNA. The proteolytic activity was higher in the fermented with LH (1.16 ± 0.03) than in the fermented with LP (0.71 ± 0.02). The ACE inhibitory activity was higher in the fermented LH (59.01 per cent) than in the fermented LP (54.45 per cent). Originality/value Fermented milk with 1.08 per cent GBF presented positive results in the analyzed variables and could be studied commercially as a functional food alternative.


2010 ◽  
Vol 2 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Seung-Woo Yeon ◽  
Young Sang You ◽  
Hyuk-Sang Kwon ◽  
Eun Hee Yang ◽  
Jung-Su Ryu ◽  
...  

2007 ◽  
Vol 63 (1) ◽  
pp. 100-105 ◽  
Author(s):  
S Yamamura ◽  
H Morishima ◽  
T Kumano-go ◽  
N Suganuma ◽  
H Matsumoto ◽  
...  

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