scholarly journals Animal Models of Colorectal Cancer in Chemoprevention and Therapeutics Development

10.5772/28497 ◽  
2012 ◽  
Author(s):  
Shubhankar Suman ◽  
Albert J. Fornace Jr. ◽  
Kamal Datt
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Therapeutics Development

scholarly journals Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications

2021 ◽  
Vol 8 (4) ◽  
pp. 59
Author(s):  
Elisabete Nascimento-Gonçalves ◽  
Bruno A.L. Mendes ◽  
Rita Silva-Reis ◽  
Ana I. Faustino-Rocha ◽  
Adelina Gama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Cancer Progression ◽  
Social Impact ◽  
Genetically Engineered ◽  
In Vivo Studies ◽  
Gastrointestinal Malignancies ◽  
Advantages And Disadvantages ◽  
Colon Cancer Progression

Colorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo studies are essential to improve and discover new ways of prevention and treatment. Dietary natural products have been under investigation for better and natural prevention, envisioning to show their potential. This manuscript intends to provide the readers a review of rodent colorectal cancer models available in the literature, highlighting their advantages and disadvantages, as well as their potential in the evaluation of several drugs and natural compounds’ effects on colorectal cancer.

scholarly journals NAP1L1: A Novel Human Colorectal Cancer Biomarker Derived From Animal Models of Apc Inactivation

2020 ◽  
Vol 10 ◽  
Author(s):  
Cleberson J. S. Queiroz ◽  
Fei Song ◽  
Karen R. Reed ◽  
Nadeem Al-Khafaji ◽  
Alan R. Clarke ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Cancer Biomarker ◽  
Human Colorectal Cancer

Abstract 4270: Induction of autophagic machinery upon oncolytic reovirus treatment in colorectal cancer cells and animal models

2019 ◽  
Author(s):  
Jeeshan Jiffry ◽  
Devika Rao ◽  
Thongthai Thavornwatanayong ◽  
Durvanand Saytoo ◽  
Titto Augustine ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Cancer Cells ◽  
Colorectal Cancer Cells

scholarly journals Animal models of colorectal peritoneal metastasis

2016 ◽  
Vol 1 (1) ◽  
pp. 23-43 ◽  
Author(s):  
Félix Gremonprez ◽  
Wouter Willaert ◽  
Wim Ceelen
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Peritoneal Carcinomatosis ◽  
Peritoneal Metastasis ◽  
Treatment Options ◽  
Genetically Engineered ◽  
Preclinical Research ◽  
Novel Treatment ◽  
Genetically Engineered Mice ◽  
Wide Range

AbstractColorectal cancer remains an important cause of mortality worldwide. The presence of peritoneal carcinomatosis (PC) causes significant symptoms and is notoriously difficult to treat. Therefore, informative preclinical research into the mechanisms and possible novel treatment options of colorectal PC is essential in order to improve the prognostic outlook in these patients. Several syngeneic and xenograft animal models of colorectal PC were established, studying a wide range of experimental procedures and substances. Regrettably, more sophisticated models such as those giving rise to spontaneous PC or involving genetically engineered mice are lacking. Here, we provide an overview of all reported colorectal PC animal models and briefly discuss their use, strengths, and limitations.

Abstract 4270: Induction of autophagic machinery upon oncolytic reovirus treatment in colorectal cancer cells and animal models

2019 ◽  
Author(s):  
Jeeshan Jiffry ◽  
Devika Rao ◽  
Thongthai Thavornwatanayong ◽  
Durvanand Saytoo ◽  
Titto Augustine ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Cancer Cells ◽  
Colorectal Cancer Cells

Colorectal cancer in animal models—A review

1987 ◽  
Vol 43 (5) ◽  
pp. 476-487 ◽  
Author(s):  
Frederick L. Greene ◽  
Lawrence S. Lamb ◽  
Myron Barwick
Keyword(s):  
Colorectal Cancer ◽  
Animal Models
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