scholarly journals Keratinocytes, Innate Immunity and Allergic Contact Dermatitis - Opportunities for the Development of In Vitro Assays to Predict the Sensitizing Potential of Chemicals

10.5772/28337 ◽  
2011 ◽  
Author(s):  
Jochem W. van der Veen ◽  
Rob J. ◽  
Henk van ◽  
Janine Ezendam
Keyword(s):  
Innate Immunity ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
In Vitro Assays ◽  
Allergic Contact

Red Grape Polyphenol Oral Administration improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis

2020 ◽  
Vol 20 ◽  
Author(s):  
Thea Magrone ◽  
Emilio Jirillo ◽  
Manrico Magrone ◽  
Matteo Antonio Russo ◽  
Paolo Romita ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Oral Administration ◽  
Allergic Contact Dermatitis ◽  
Laboratory Data ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Red Grape ◽  
Allergic Contact ◽  
Drop Outs

Background: Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia cultivar), to peripheral lymphomonocytes from patients affected by allergic contact dermatitis (ACD) to nickel (Ni) could reduce release of pro-inflammatory cytokines and nitric oxide (NO), while increasing levels of interleukin (IL)-10, an anti-inflammatory cytokine. Objective: To assess whether an intervention with oral administration of polyphenols leads to a reduction of peripheral biomarkers in ACD patients. Method: At T0, 25 patients affected by ACD to Ni were orally administered with 300 mg polyphenols prodie extracted from seeds of red grape (Nero di Troia cultivar) (NATUR-OX®) for 3 months (T1). Other 25 patients affected by ACD to Ni received placebo only for the same period of time. Serum biomarkers were analyzed at T0 and T1. In both groups seven drop outs were recorded. Result: At T1 in comparison to T0, in treated patients, values of IFN-γ, IL-4, IL-17, PTX3 and NO decreased, while IL-10 levels increased when compared with T0 values. Conversely, in placebo-treated patients no modifications of biomarkers were evaluated at T1. Conclusion: Present laboratory data rely on the anti-oxidant, anti-inflammatory and anti-allergic properties of polyphenols.

scholarly journals Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis

2018 ◽  
Vol 93 (2) ◽  
pp. 242-250 ◽  
Author(s):  
Marilene Chaves Silvestre ◽  
Maria Notomi Sato ◽  
Vitor Manoel Silva dos Reis
Keyword(s):  
Innate Immunity ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Regulatory Mechanisms ◽  
Allergic Contact

scholarly journals Mechanisms of chemical-induced innate immunity in allergic contact dermatitis

Allergy ◽  
2011 ◽  
Vol 66 (9) ◽  
pp. 1152-1163 ◽  
Author(s):  
S. F. Martin ◽  
P. R. Esser ◽  
F. C. Weber ◽  
T. Jakob ◽  
M. A. Freudenberg ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Allergic Contact

Impact of 25 Years of In Vitro Testing in Allergic Contact Dermatitis

1989 ◽  
pp. 569-577 ◽  
Author(s):  
B. M. E. von Blomberg-van der Flier ◽  
D. P. Bruynzeel ◽  
R. J. Scheper
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
In Vitro Testing ◽  
Allergic Contact

scholarly journals Development and Evaluation of Liposomes for Topical Delivery of Tacrolimus (Fk-506)

2010 ◽  
Vol 2 (3) ◽  
pp. 585 ◽  
Author(s):  
S. S. Patel ◽  
M. S. Patel ◽  
S. Salampure ◽  
B. Vishwanath ◽  
N. M. Patel
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Entrapment Efficiency ◽  
Topical Delivery ◽  
Stability Study ◽  
Multilamellar Vesicle ◽  
Cholesterol Ratio ◽  
Acd Model ◽  
Allergic Contact

In the present work Tacrolimus loaded liposomal systems were developed and evaluated for their topical delivery. Neutral multilamellar liposomes (MLVs) were prepared by thin film hydration method. The amount of drug loaded into vesicles ranged from 4.4 mg per 115mg to 8.2mg per 140mg of total lipid. Entrapment efficiency of tacrolimus in liposomes was studied by altering the amount of cholesterol ratio to lipid ratio. After performing stability study at different temperatures (4, 25, and 37°C) was affirms that drug leakage increased at higher temperature. The in-vitro permeation study shows significant reduced permeation with tacrolimus liposomes compared with free tacrolimus in propylene glycol. The animal study carried out on allergic contact dermatitis (ACD) model in rats showed that 0.03% tacrolimus liposomal gel exhibited similar activity when compared with 0.03% marketed tacrolimus ointment. It is also likely that tacrolimus liposomal gel which leads no visible or palpable residue when applied on skin would be more appealing to patients than conventional ointment. Overall study suggests that tacrolimus can be effectively incorporated in liposomes and can be used for the treatment of atopic dermatitis.  Keywords: Tacrolimus; Multilamellar vesicle; Allergic contact dermatitis.   © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i3.3258               J. Sci. Res. 2 (3), 587-598  (2010) 

Encapsulation of hydrophobic allergens into nanoparticles improves the in vitro immunological diagnosis of allergic contact dermatitis

2015 ◽  
Vol 11 (4) ◽  
pp. 1029-1033 ◽  
Author(s):  
Angèle Cortial ◽  
Audrey Nosbaum ◽  
Aurore Rozières ◽  
Marie Baeck ◽  
Laurence de Montjoye ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Immunological Diagnosis ◽  
Allergic Contact
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