scholarly journals Screening of Foot Inflammation in Diabetic Patients by Non-Invasive Imaging Modalities

10.5772/28225 ◽  
2011 ◽  
Author(s):  
Takashi Nagase ◽  
Hiromi Sanada ◽  
Makoto Oe ◽  
Kimie Takehara ◽  
Kaoru Nishide ◽  
...  
Keyword(s):  
Imaging Modalities ◽  
Diabetic Patients ◽  
Non Invasive

scholarly journals Current Progress and Perspective: Clinical Imaging of Islet Transplantation

Life ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 213
Author(s):  
Taylor Marie Richards ◽  
Aixia Sun ◽  
Hasaan Hayat ◽  
Neil Robertson ◽  
Zhaoda Zhang ◽  
...  
Keyword(s):  
Beta Cell ◽  
Islet Transplantation ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Molecular Probes ◽  
Imaging Modalities ◽  
Diabetic Patients ◽  
Clinical Imaging ◽  
Non Invasive

Islet transplantation has great potential as a cure for type 1 diabetes. At present; the lack of a clinically validated non-invasive imaging method to track islet grafts limits the success of this treatment. Some major clinical imaging modalities and various molecular probes, which have been studied for non-invasive monitoring of transplanted islets, could potentially fulfill the goal of understanding pathophysiology of the functional status and viability of the islet grafts. In this current review, we summarize the recent clinical studies of a variety of imaging modalities and molecular probes for non-invasive imaging of transplanted beta cell mass. This review also includes discussions on in vivo detection of endogenous beta cell mass using clinical imaging modalities and various molecular probes, which will be useful for longitudinally detecting the status of islet transplantation in Type 1 diabetic patients. For the conclusion and perspectives, we highlight the applications of multimodality and novel imaging methods in islet transplantation.

Review of Various Tasks Performed in the Preprocessing Phase of a Diabetic Retinopathy Diagnosis System

2020 ◽  
Vol 16 (4) ◽  
pp. 397-426
Author(s):  
Muhammad Nadeem Ashraf ◽  
Muhammad Hussain ◽  
Zulfiqar Habib
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Vessels ◽  
Early Stage ◽  
Spherical Shape ◽  
Cost Effective ◽  
Lesion Detection ◽  
Diabetic Patients ◽  
Cad System ◽  
Non Invasive ◽  
Optic Discs

Diabetic Retinopathy (DR) is a major cause of blindness in diabetic patients. The increasing population of diabetic patients and difficulty to diagnose it at an early stage are limiting the screening capabilities of manual diagnosis by ophthalmologists. Color fundus images are widely used to detect DR lesions due to their comfortable, cost-effective and non-invasive acquisition procedure. Computer Aided Diagnosis (CAD) of DR based on these images can assist ophthalmologists and help in saving many sight years of diabetic patients. In a CAD system, preprocessing is a crucial phase, which significantly affects its performance. Commonly used preprocessing operations are the enhancement of poor contrast, balancing the illumination imbalance due to the spherical shape of a retina, noise reduction, image resizing to support multi-resolution, color normalization, extraction of a field of view (FOV), etc. Also, the presence of blood vessels and optic discs makes the lesion detection more challenging because these two artifacts exhibit specific attributes, which are similar to those of DR lesions. Preprocessing operations can be broadly divided into three categories: 1) fixing the native defects, 2) segmentation of blood vessels, and 3) localization and segmentation of optic discs. This paper presents a review of the state-of-the-art preprocessing techniques related to three categories of operations, highlighting their significant aspects and limitations. The survey is concluded with the most effective preprocessing methods, which have been shown to improve the accuracy and efficiency of the CAD systems.

Indole as a new tentative marker in exhaled breath for non-invasive blood glucose monitoring of diabetic subjects

2021 ◽  
Author(s):  
Herbert Fink ◽  
Tim Maihöfer ◽  
Jeffrey Bender ◽  
Jochen Schulat
Keyword(s):  
Blood Glucose ◽  
Diabetes Management ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring ◽  
Glucose Measurement ◽  
Diabetic Patients ◽  
Exhaled Breath ◽  
Invasive Approach ◽  
Test Strips ◽  
Non Invasive

Abstract Blood glucose monitoring (BGM) is the most important part of diabetes management. In classical BGM, glucose measurement by test strips involves invasive finger pricking. We present results of a clinical study that focused on a non-invasive approach based on volatile organic compounds (VOCs) in exhaled breath. Main objective was the discovery of markers for prediction of blood glucose levels (BGL) in diabetic patients. Exhaled breath was measured repeatedly in 60 diabetic patients (30 type 1, 30 type 2) in fasting state and after a standardized meal. Proton Transfer Reaction Time of Flight Mass Spectrometry (PTR-ToF-MS) was used to sample breath every 15 minutes for a total of six hours. BGLs were tested in parallel via BGM test strips. VOC signals were plotted against glucose trends for each subject to identify correlations. Exhaled indole (a bacterial metabolite of tryptophan) showed significant mean correlation to BGL (with negative trend) and significant individual correlation in 36 patients. The type of diabetes did not affect this result. Additional experiments of one healthy male subject by ingestion of lactulose and 13C-labeled glucose (n=3) revealed that exhaled indole does not directly originate from food digestion by intestinal microbiota. As indole has been linked to human glucose metabolism, it might be a tentative marker in breath for non-invasive BGM. Clinical studies with greater diversity are required for confirmation of such results and further investigation of metabolic pathways.

Non-Invasive Monitoring of Glucose Level Changes Utilizing a mm-Wave Radar System

2018 ◽  
Vol 10 (3) ◽  
pp. 10-29 ◽  
Author(s):  
George Shaker ◽  
Karly Smith ◽  
Ala Eldin Omer ◽  
Shuo Liu ◽  
Clement Csech ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Detection System ◽  
Diabetic Patients ◽  
Glucose Detection ◽  
60 Ghz ◽  
Non Invasive ◽  
Wave Radar ◽  
Recent Developments ◽  
Blood Glucose Concentrations ◽  
Different Levels

This article discusses recent developments in the authors' experiments using Google's Soli alpha kit to develop a non-invasive blood glucose detection system. The Soli system (co-developed by Google and Infineon) is a 60 GHz mm-wave radar that promises a small, mobile, and wearable platform intended for gesture recognition. They have retrofitted the setup for the system and their experiments outline a proof-of-concept prototype to detect changes of the dielectric properties of solutions with different levels of glucose and distinguish between different concentrations. Preliminary results indicated that mm-waves are suitable for glucose detection among biological mediums at concentrations similar to blood glucose concentrations of diabetic patients. The authors discuss improving the repeatability and scalability of the system, other systems of glucose detection, and potential user constraints of implementation.

scholarly journals Multiplexed Non-invasive in vivo Imaging to Assess Metabolism and Receptor Engagement in Tumor Xenografts

2019 ◽  
Author(s):  
Alena Rudkouskaya ◽  
Nattawut Sinsuebphon ◽  
Marien Ochoa ◽  
Joe E. Mazurkiewicz ◽  
Xavier Intes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Metabolic Response ◽  
Imaging Modalities ◽  
Wide Field ◽  
Receptor Ligand ◽  
Non Invasive ◽  
Intracellular Drug Delivery

AbstractFollowing an ever-increased focus on personalized medicine, there is a continuing need to develop preclinical molecular imaging modalities to guide the development and optimization of targeted therapies. To date, non-invasive quantitative imaging modalities that can comprehensively assess simultaneous cellular drug delivery efficacy and therapeutic response are lacking. In this regard, Near-Infrared (NIR) Macroscopic Fluorescence Lifetime Förster Resonance Energy Transfer (MFLI-FRET) imaging offers a unique method to robustly quantify receptor-ligand engagement in vivo and subsequent intracellular internalization, which is critical to assess the delivery efficacy of targeted therapeutics. However, implementation of multiplexing optical imaging with FRET in vivo is challenging to achieve due to spectral crowding and cross-contamination. Herein, we report on a strategy that relies on a dark quencher that enables simultaneous assessment of receptor-ligand engagement and tumor metabolism in intact live mice. First, we establish that IRDye QC-1 (QC-1) is an effective NIR dark acceptor for the FRET-induced quenching of donor Alexa Fluor 700 (AF700) using in vitro NIR FLI microscopy and in vivo wide-field MFLI imaging. Second, we report on simultaneous in vivo imaging of the metabolic probe IRDye 800CW 2-deoxyglucose (2-DG) and MFLI-FRET imaging of NIR-labeled transferrin FRET pair (Tf-AF700/Tf-QC-1) uptake in tumors. Such multiplexed imaging revealed an inverse relationship between 2-DG uptake and Tf intracellular delivery, suggesting that 2-DG signal may predict the efficacy of intracellular targeted delivery. Overall, our methodology enables for the first time simultaneous non-invasive monitoring of intracellular drug delivery and metabolic response in preclinical studies.

scholarly journals Imaging modalities for the non-invasive diagnosis of endometriosis

2016 ◽  
Author(s):  
Vicki Nisenblat ◽  
Patrick MM Bossuyt ◽  
Cindy Farquhar ◽  
Neil Johnson ◽  
M Louise Hull
Keyword(s):  
Imaging Modalities ◽  
Non Invasive

Understanding the Need for a Non-invasive Wearable Real-time Database Device for Diabetic Patients

2018 ◽  
Vol 20 (2) ◽  
pp. 190-196 ◽  
Author(s):  
Elmer Jeto Gomes Ataide ◽  
Rajesh Kumar Sinha ◽  
G. Arun Maiya
Keyword(s):  
Health Care ◽  
Real Time ◽  
Medical Records ◽  
Wearable Devices ◽  
Care Process ◽  
Diabetic Patients ◽  
Quality Health Care ◽  
Non Invasive ◽  
Quality Health ◽  
Real Time Database

Diabetes occurs when the pancreas in the human body does not secrete sufficient insulin. It is a disease that is growing rapidly and affecting many lives. Hence, it needs constant monitoring. Wearable devices are those devices that are present on your person at all times. If the monitoring of this disease could be paired with wearable devices along with enabling real-time documentation in the patients’ medical records, it would benefit both the caregivers and the patients by saving time, money, effort and the amount of work put in by both during the health care process, hence, aiding in the delivery of quality health care. This article deals with identifying the existing wearable devices in detecting diabetes or risk of diabetes non-invasively and further scope of research in the respective area.

Future Trends in Intravascular Imaging

2011 ◽  
pp. 350-354
Author(s):  
George D. Giannoglou ◽  
Yiannis S. Chatzizisis
Keyword(s):  
Early Diagnosis ◽  
Potential Application ◽  
Vulnerable Plaque ◽  
Imaging Modalities ◽  
Intravascular Imaging ◽  
Future Trends ◽  
Regional Characteristics ◽  
Non Invasive ◽  
Vulnerable Plaques ◽  
Coronary Events

Vulnerable plaques have certain histopathologic and regional characteristics. The advent of novel invasive and non-invasive imaging modalities aim to identify the histopathologic and regional characteristics of vulnerable plaque, thereby enabling the early diagnosis and potential application of treatments strategies to avert future acute coronary events.

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