scholarly journals Fighting Virus and Parasites with Fish Cytotoxic Cells

10.5772/28122 ◽  
2012 ◽  
Author(s):  
M. ngeles ◽  
Jos Meseguer ◽  
Alberto Cuest
Keyword(s):  
Cytotoxic Cells

Generation of CD8 (T8) cytotoxic cells has a preferential requirement for CD4+2H4− inducer cells

1988 ◽  
Vol 111 (2) ◽  
pp. 379-389 ◽  
Author(s):  
Richard S. Kalish ◽  
Chikao Morimoto ◽  
Stuart F. Schlossman
Keyword(s):  
Cytotoxic Cells

Splenic cytotoxic cells recognize surface HSP70 on culture-adapted EL-4 mouse lymphoma cells

2000 ◽  
Vol 74 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Eugene D Ponomarev ◽  
Tatyana N Tarasenko ◽  
Alexander M Sapozhnikov
Keyword(s):  
Lymphoma Cells ◽  
Cytotoxic Cells ◽  
Mouse Lymphoma Cells ◽  
Mouse Lymphoma

Natural cytotoxic cells and tumour surveillance in vivo

1990 ◽  
Vol 26 (8) ◽  
pp. 863-864 ◽  
Author(s):  
Y. Cheng Smart ◽  
Paul A. Tooney ◽  
Margaret L. Farrelly ◽  
Joan H. Brien ◽  
Robert C. Burton
Keyword(s):  
Cytotoxic Cells ◽  
Natural Cytotoxic

scholarly journals Autoreactive cytotoxic cells in rabbits after prolonged immunostimulation

1992 ◽  
Vol 89 (5) ◽  
pp. 243-246 ◽  
Author(s):  
F. Galdiero ◽  
C. Romano Carratelli ◽  
I. Nuzzo ◽  
C. Bentivoglio ◽  
M.P. Galdiero
Keyword(s):  
Cytotoxic Cells

scholarly journals Early Development of CD8-Negative and CD8-Positive MHC-Unrestricted Cytotoxic Cells Induced by Alloantigen Inoculation in Mice

1990 ◽  
Vol 34 (9) ◽  
pp. 775-785 ◽  
Author(s):  
Yasuaki Nishi ◽  
Tomohide Hosokawa ◽  
Akira Aoike ◽  
Keiichi Kawai ◽  
Takeshi Kamahora
Keyword(s):  
Early Development ◽  
Cytotoxic Cells

Nonspecific cytotoxic cells of teleosts are armed with multiple granzymes and other components of the granule exocytosis pathway

2006 ◽  
Vol 43 (8) ◽  
pp. 1152-1162 ◽  
Author(s):  
Kesavannair Praveen ◽  
John H Leary III ◽  
Donald L. Evans ◽  
Liliana Jaso-Friedmann
Keyword(s):  
Granule Exocytosis ◽  
Cytotoxic Cells ◽  
Nonspecific Cytotoxic Cells

scholarly journals Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in situ hybridization.

1989 ◽  
Vol 169 (5) ◽  
pp. 1565-1581 ◽  
Author(s):  
C L Cooper ◽  
C Mueller ◽  
T A Sinchaisri ◽  
C Pirmez ◽  
J Chan ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fold Increase ◽  
Delayed Type Hypersensitivity ◽  
Cell Mediated Immunity ◽  
Serine Esterase ◽  
Ifn Gamma ◽  
Cytotoxic Cells ◽  
Selective Increase ◽  
Reversal Reaction

Analysis of tissue lesions of the major reactional states of leprosy was undertaken to study the immune mechanisms underlying regulation of cell-mediated immunity and delayed-type hypersensitivity (DTH) in man. In situ hybridization hybridization of reversal reaction biopsy specimens for INF-gamma mRNA expression revealed a 10-fold increase in specific mRNA-containing cells over that observed in unresponsive lepromatous patients. Expression of huHF serine esterase, a marker for T cytotoxic cells, were fourfold increased in reversal reaction and tuberculoid lesions above that detected in unresponsive lepromatous individuals. Immunohistology of reversal reactions confirmed a selective increase of Th and T cytotoxic cells in the cellular immune response. Of interest, the microanatomic location of these serine esterase mRNA-containing cells was identical to the distribution of CD4+ cells. Analysis of erythema nodosum leprosum (ENL) lesions revealed differences in the underlying immune processes in comparison with reversal reaction lesions. Although phenotypic Th cells predominated in ENL lesions, IFN-gamma and serine esterase gene expression were markedly reduced. We suggest that reversal reactions represent a hyperimmune DTH response characterized by a selective increase of CD4+ IFN-gamma producing cells and T cytotoxic cells, which result in the clearing of bacilli and concomitant tissue damage. In contrast, ENL reactions may be viewed as a transient diminution of Ts cells and activity leading to a partial and transient augmentation in cell-mediated immunity, perhaps sufficient to result in antibody and immune complex formation, but insufficient to clear bacilli from lesions.

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