scholarly journals Steroid Hormones in Drosophila: How Ecdysone Coordinates Developmental Signalling with Cell Growth and Division

10.5772/27927 ◽  
2012 ◽  
Author(s):  
Leonie Quinn ◽  
Jane Lin ◽  
Nicola Cranna ◽  
Jue Er Amanda Lee ◽  
Naomi Mitchell ◽  
...  
Keyword(s):  
Cell Growth ◽  
Steroid Hormones ◽  
Developmental Signalling

Interaction of endocannabinoid system and steroid Hormones in the control of colon cancer cell growth

2011 ◽  
Vol 227 (1) ◽  
pp. 250-258 ◽  
Author(s):  
Maria C. Proto ◽  
Patrizia Gazzerro ◽  
Luciano Di Croce ◽  
Antonietta Santoro ◽  
Anna M. Malfitano ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Growth ◽  
Steroid Hormones ◽  
Cancer Cell ◽  
Endocannabinoid System ◽  
Colon Cancer Cell ◽  
Cancer Cell Growth

scholarly journals A Review of Progesterone Effects on Human Melanoma Cell Growth In-Vitro

2021 ◽  
Author(s):  
Pandurangan Ramaraj
Keyword(s):  
Cell Growth ◽  
Steroid Hormones ◽  
Melanoma Cell ◽  
Clinical Studies ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
And Migration ◽  
Post Menopausal

Progesterone, a female sex hormone not only has a role in reproduction, but also in protecting females in melanoma. A survey of steroid hormones actions steroid hormones actions survey on melanoma cells and literature survey showed that progesterone inhibited mouse and human melanoma cell growth significantly in-vitro. Progesterone not only inhibited cell growth, but also affected adhesion and migration functions (essential for metastasis) in-vitro. This observation correlated with the clinical studies where they had shown showed an increased survival and delayed metastasis in menstruating females in melanoma. Further, progesterone level in menstruating females (1000–1500 ng/dL) compared to post-menopausal females (20–100 ng/dL) also correlated with previous clinical studies. Progesterone action on melanoma cells, as reported by other researchers also supported the findings from this lab. Hence, progesterone could be the steroid hormone protecting menstruating females in melanoma. Moreover, our recent studies showed that progesterone suppressed pro-inflammatory cytokine IL-8 secretion by the melanoma cells, which decreased melanoma cell growth in-vitro. Hence, progesterone apart from reproductive function may also be involved in protecting menstruating females in melanoma.

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