scholarly journals Cell Therapy for Ischemic Peripheral Neuropathy

10.5772/27794 ◽  
2012 ◽  
Author(s):  
Yousuke Katsuda ◽  
Ken Arima ◽  
Hisashi Kai ◽  
Tsutomu Imaizumi
Keyword(s):  
Peripheral Neuropathy ◽  
Cell Therapy

scholarly journals Stem Cell Therapy Enhances Motor Activity of Triceps Surae Muscle in Mice with Hereditary Peripheral Neuropathy

2021 ◽  
Vol 22 (21) ◽  
pp. 12026
Author(s):  
Iryna Govbakh ◽  
Vitalii Kyryk ◽  
Alina Ustymenko ◽  
Volodymyr Rubtsov ◽  
Oleg Tsupykov ◽  
...  
Keyword(s):  
Stem Cell ◽  
Peripheral Neuropathy ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Muscle Tension ◽  
Fold Increase ◽  
Triceps Surae ◽  
Partial Restoration ◽  
Charcot Marie Tooth Disease ◽  
Hereditary Peripheral Neuropathy

Impaired motor and sensory functions are the main features of Charcot–Marie–Tooth disease. Mesenchymal stem cell (MSCs) therapy is one of the possible treatments for this disease. It was assumed that MSCs therapy can improve the contractile properties of the triceps surae (TS) muscles in mice with hereditary peripheral neuropathy. Murine adipose-derived mesenchymal stromal cells (AD-MSCs) were obtained for transplantation into TS muscles of FVB-C-Tg(GFPU)5Nagy/J mice. Three months after AD-MSCs transplantation, animals were subjected to electrophysiological investigations. Parameters of TS muscle tension after intermittent high frequency electrical sciatic nerve stimulations were analyzed. It was found that force of TS muscle tension contraction in animals after AD-MSCs treatment was two-time higher than in untreated mice. Normalized values of force muscle contraction in different phases of electrical stimulation were 0.3 ± 0.01 vs. 0.18 ± 0.01 and 0.26 ± 0.03 vs. 0.13 ± 0.03 for treated and untreated animals, respectively. It is assumed that the two-fold increase in TS muscle strength was caused by stem cell therapy. Apparently, AD-MSCs therapy can promote nerve regeneration and partial restoration of muscle function, and thus can be a potential therapeutic agent for the treatment of peripheral neuropathies.

1468: Novel Cell Therapy Approaches for Renal Failure

2006 ◽  
Vol 175 (4S) ◽  
pp. 474-474
Author(s):  
Akira Joraku ◽  
Toshihiko Machiguchi ◽  
James J. Yoo ◽  
Anthony Atala
Keyword(s):  
Renal Failure ◽  
Cell Therapy
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