scholarly journals Nonlinear Analysis for Evaluation of Age-Related Muscle Performance Using Surface Electromyography

10.5772/27536 ◽  
2012 ◽  
Author(s):  
Hiroki Takada ◽  
Yasuyuki Matsuura ◽  
Tomoki Shiozawa ◽  
Masaru Miyao
Keyword(s):  
Nonlinear Analysis ◽  
Surface Electromyography ◽  
Muscle Performance ◽  
Age Related

Early effects of ageing on the mechanical performance of isolated locomotory (EDL) and respiratory (diaphragm) skeletal muscle using the work-loop technique

2014 ◽  
Vol 307 (6) ◽  
pp. R670-R684 ◽  
Author(s):  
Jason Tallis ◽  
Rob S. James ◽  
Alexander G. Little ◽  
Val M. Cox ◽  
Michael J. Duncan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Power Output ◽  
Muscle Performance ◽  
Maximal Power ◽  
Maximal Power Output ◽  
Age Related ◽  
Loop Technique ◽  
Edl Muscle ◽  
Work Loop

Previous isolated muscle studies examining the effects of ageing on contractility have used isometric protocols, which have been shown to have poor relevance to dynamic muscle performance in vivo. The present study uniquely uses the work-loop technique for a more realistic estimation of in vivo muscle function to examine changes in mammalian skeletal muscle mechanical properties with age. Measurements of maximal isometric stress, activation and relaxation time, maximal power output, and sustained power output during repetitive activation and recovery are compared in locomotory extensor digitorum longus (EDL) and core diaphragm muscle isolated from 3-, 10-, 30-, and 50-wk-old female mice to examine the early onset of ageing. A progressive age-related reduction in maximal isometric stress that was of greater magnitude than the decrease in maximal power output occurred in both muscles. Maximal force and power developed earlier in diaphragm than EDL muscle but demonstrated a greater age-related decline. The present study indicates that ability to sustain skeletal muscle power output through repetitive contraction is age- and muscle-dependent, which may help rationalize previously reported equivocal results from examination of the effect of age on muscular endurance. The age-related decline in EDL muscle performance is prevalent without a significant reduction in muscle mass, and biochemical analysis of key marker enzymes suggests that although there is some evidence of a more oxidative fiber type, this is not the primary contributor to the early age-related reduction in muscle contractility.

Automated rodent in situ muscle contraction assay and myofiber organization analysis in sarcopenia animal models

2012 ◽  
Vol 112 (12) ◽  
pp. 2087-2098 ◽  
Author(s):  
H. Weber ◽  
A. Rauch ◽  
S. Adamski ◽  
K. Chakravarthy ◽  
A. Kulkarni ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Force Measurement ◽  
Muscle Performance ◽  
Area Measurement ◽  
Micro Ct ◽  
Cross Sectional ◽  
Muscle Aging ◽  
Age Related

Age-related sarcopenia results in frailty and decreased mobility, which are associated with increased falls and long-term disability in the elderly. Given the global increase in lifespan, sarcopenia is a growing, unmet medical need. This report aims to systematically characterize muscle aging in preclinical models, which may facilitate the development of sarcopenia therapies. Naïve rats and mice were subjected to noninvasive micro X-ray computed tomography (micro-CT) imaging, terminal in situ muscle function characterizations, and ATPase-based myofiber analysis. We developed a Definiens (Parsippany, NJ)-based algorithm to automate micro-CT image analysis, which facilitates longitudinal in vivo muscle mass analysis. We report development and characterization of translational in situ skeletal muscle performance assay systems in rat and mouse. The systems incorporate a custom-designed animal assay stage, resulting in enhanced force measurement precision, and LabVIEW (National Instruments, Austin, TX)-based algorithms to support automated data acquisition and data analysis. We used ATPase-staining techniques for myofibers to characterize fiber subtypes and distribution. Major parameters contributing to muscle performance were identified using data mining and integration, enabled by Labmatrix (BioFortis, Columbia, MD). These technologies enabled the systemic and accurate monitoring of muscle aging from a large number of animals. The data indicated that longitudinal muscle cross-sectional area measurement effectively monitors change of muscle mass and function during aging. Furthermore, the data showed that muscle performance during aging is also modulated by myofiber remodeling factors, such as changes in myofiber distribution patterns and changes in fiber shape, which affect myofiber interaction. This in vivo muscle assay platform has been applied to support identification and validation of novel targets for the treatment of sarcopenia.

Adaptive stretch-shortening contractions: diminished regenerative capacity with aging

2008 ◽  
Vol 33 (6) ◽  
pp. 1181-1191 ◽  
Author(s):  
Brent A. Baker ◽  
Melinda S. Hollander ◽  
Robert R. Mercer ◽  
Michael L. Kashon ◽  
Robert G. Cutlip
Keyword(s):  
Skeletal Muscle ◽  
Tibialis Anterior Muscle ◽  
Recovery Period ◽  
Muscle Performance ◽  
Muscle Adaptation ◽  
Regenerative Capacity ◽  
Age Related ◽  
Old Rats ◽  
Shortening Contractions ◽  
Muscle Remodeling

This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in young and old rats, following an acute exposure to adaptive SSCs at 6, 24, 48, 72, and 120 h postexposure (n = 6 for each age at each recovery period). Following SSC exposure, all performance measures were decreased in old rats throughout the 120 h acute phase. Estimates of edema were increased in the old vs. young exposed muscle at 120 h recovery. Both young and old rats displayed an increase in developmental myosin heavy chain (MHCdev+) labeling in the exposed muscle, indicating muscle regeneration. However, old rats displayed diminished MHCdev+ labeling, compared with young rats, suggesting limited remodeling and (or) regenerative capacity. Based on these data, diminished local muscle remodeling and (or) regeneration with aging may limit skeletal muscle adaptation following mechanical loading.

scholarly journals Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation

2019 ◽  
Vol 8 (4) ◽  
pp. 488 ◽  
Author(s):  
Darren G. Candow ◽  
Scott C. Forbes ◽  
Philip D. Chilibeck ◽  
Stephen M. Cornish ◽  
Jose Antonio ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Healthy Aging ◽  
Creatine Supplementation ◽  
Falls Prevention ◽  
Muscle Performance ◽  
Low Grade ◽  
Age Related ◽  
Risk Of Falls ◽  
Aging Adults ◽  
Aging Muscle

Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults.

scholarly journals Effects of Slaughter Age on Muscle Characteristics and Meat Quality Traits of Da-Heng Meat Type Birds

Animals ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 69 ◽  
Author(s):  
Jingjing Li ◽  
Chaowu Yang ◽  
Han Peng ◽  
Huadong Yin ◽  
Yan Wang ◽  
...  
Keyword(s):  
Meat Quality ◽  
Breast Muscle ◽  
Muscle Performance ◽  
Chicken Breast ◽  
Drip Loss ◽  
Quality Traits ◽  
Meat Quality Traits ◽  
Age Related ◽  
Slaughter Age ◽  
Meat Type

Due to the increasing demand for producing chickens with high meat quality, there is a need to determine its mode of action on chicken meat quality traits across a wider age spectrum. In this study, five groups of 200 male Da-Heng meat type birds were reared until slaughter age of 60, 90, 120, 150, 180 days old and breast muscle performance, meat quality traits, and myofiber characteristics were evaluated. The larger body weight and breast weight of chicken are based on larger myofiber diameter and area, less myofiber density for the older birds than younger birds. There was an age effect on all meat quality traits of chicken breast muscle (p < 0.05). Older chickens often presented a higher pH, lower drip loss, higher shear force, darker, and redder breast meat. The correlation coefficients showed that myofiber characteristics played an important role in breast pH values, drip loss, and meat color (p < 0.05). Besides, significant correlations were also found between meat quality traits (p < 0.05). Further studies are needed to explore the biochemical character and potential molecular mechanism of chicken breast muscle to determine the factors that causes these age-related differences in meat quality in the current study.

Age-Related Changes in Shear Wave Elastography Parameters of the Gastrocnemius Muscle in Association with Physical Performance in Healthy Adults

Gerontology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Jing Pang ◽  
Mingxiao Wu ◽  
Xiaoshuang Liu ◽  
Kan Gao ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Shear Wave ◽  
Physical Performance ◽  
Gastrocnemius Muscle ◽  
Early Recognition ◽  
Muscle Thickness ◽  
Shear Wave Elastography ◽  
Step Length ◽  
Muscle Stiffness ◽  
Muscle Performance ◽  
Age Related

Background/Aims: to investigate new indicators for early recognition of physical performance decline. Shear wave elastrography, a new ultrasound technique, was discussed in this study. Methods: Gastrocnemius muscle thickness and muscle stiffness were detected by traditional ultrasound and shear wave elastrography in 108 Chinese aged 20–85 years, and then analyzed with physical performance together. Results: After 70 years old, the decline rate of muscle stiffness under contractive state was significantly faster than that of muscle thickness, muscle relaxed stiffness, and physical performance indicators. The correlation analysis showed that gastrocnemius contractive stiffness was positively related with handgrip strength, step length, and fast gait speed after adjusted by age and gender. Among physical performance variants, step length had closer relationship with muscle strength than repeated chair stands. Conclusions: The detection of gastrocnemius muscle by shear wave elastography reflected the change of lower-limb muscle stiffness with aging. Muscle contractive stiffness and step length measurement supplied novel ways for muscle performance and motor function assessment.

Sign in / Sign up

Export Citation Format

Share Document