scholarly journals The Use of Pomegranate (Punica granatum L.) Phenolic Compounds as Potential Natural Prevention Against IBDs

10.5772/27532 ◽  
2012 ◽  
Author(s):  
Sylvie Hollebeeck ◽  
Yvan Larondelle ◽  
Yves-Jacques Schneider ◽  
Alexandrine During
Keyword(s):  
Phenolic Compounds ◽  
Punica Granatum ◽  
Punica Granatum L

β-Cyclodextrin-assisted extraction of phenolic compounds from pomegranate (Punica granatum L.) peel: A new strategy for anthocyanin copigmentation

LWT ◽  
2021 ◽  
pp. 112136
Author(s):  
Sara Kalantari ◽  
Leila Roufegarinejad ◽  
Sajad Pirsa ◽  
Mehdi Gharekhani ◽  
Mahnaz Tabibiazar
Keyword(s):  
Phenolic Compounds ◽  
Punica Granatum ◽  
Assisted Extraction ◽  
New Strategy ◽  
Punica Granatum L

Evaluation of the effect of ultrasonic frequency in the extraction of phenolic compounds of pomegranate (Punica granatum L.)

2016 ◽  
Author(s):  
CAROLINA MEKARU ◽  
MAURICIO ARIEL ROSTAGNO ◽  
Ana Paula da Fonseca Machado ◽  
Maria del Pilar Garcia Mendoza ◽  
Julian Martínez
Keyword(s):  
Phenolic Compounds ◽  
Punica Granatum ◽  
Ultrasonic Frequency ◽  
Punica Granatum L

Combining pressurized liquids with ultrasound to improve the extraction of phenolic compounds from pomegranate peel (Punica granatum L.)

2018 ◽  
Vol 48 ◽  
pp. 151-162 ◽  
Author(s):  
Beatriz Rocchetti Sumere ◽  
Mariana Corrêa de Souza ◽  
Mariana Pacífico dos Santos ◽  
Rosângela Maria Neves Bezerra ◽  
Diogo Thimoteo da Cunha ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Punica Granatum ◽  
Pomegranate Peel ◽  
Punica Granatum L ◽  
Pressurized Liquids

scholarly journals Antifungal Activity and DNA Topoisomerase Inhibition of Hydrolisable Tannins from Punica granatum L.

2021 ◽  
Vol 22 (8) ◽  
pp. 4175
Author(s):  
Virginia Brighenti ◽  
Ramona Iseppi ◽  
Luca Pinzi ◽  
Annamaria Mincuzzi ◽  
Antonio Ippolito ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Antifungal Activity ◽  
Active Compound ◽  
Fungal Pathogens ◽  
Fungal Infections ◽  
Punica Granatum ◽  
Human Pathogens ◽  
First Time ◽  
Punica Granatum L

Punica granatum L. (pomegranate) fruit is known to be an important source of bioactive phenolic compounds belonging to hydrolysable tannins. Pomegranate extracts have shown antifungal activity, but the compounds responsible for this activity and their mechanism/s of action have not been completely elucidated up to now. The aim of the present study was the investigation of the inhibition ability of a selection of pomegranate phenolic compounds (i.e., punicalagin, punicalin, ellagic acid, gallic acid) on both plant and human fungal pathogens. In addition, the biological target of punicalagin was identified here for the first time. The antifungal activity of pomegranate phenolics was evaluated by means of Agar Disk Diffusion Assay and minimum inhibitory concentration (MIC) evaluation. A chemoinformatic analysis predicted for the first time topoisomerases I and II as potential biological targets of punicalagin, and this prediction was confirmed by in vitro inhibition assays. Concerning phytopathogens, all the tested compounds were effective, often similarly to the fungicide imazalil at the label dose. Particularly, punicalagin showed the lowest MIC for Alternaria alternata and Botrytis cinerea, whereas punicalin was the most active compound in terms of growth control extent. As for human pathogens, punicalagin was the most active compound among the tested ones against Candida albicans reference strains, as well as against the clinically isolates. UHPLC coupled with HRMS indicated that C. albicans, similarly to the phytopathogen Coniella granati, is able to hydrolyze both punicalagin and punicalin as a response to the fungal attack. Punicalagin showed a strong inhibitory activity, with IC50 values of 9.0 and 4.6 µM against C. albicans topoisomerases I and II, respectively. Altogether, the results provide evidence that punicalagin is a valuable candidate to be further exploited as an antifungal agent in particular against human fungal infections.

scholarly journals Comparative study of phenolic compounds and their antioxidant attributes of eighteen pomegranate (Punica granatum L.) cultivars grown in Morocco

2017 ◽  
Vol 10 ◽  
pp. S2675-S2684 ◽  
Author(s):  
Ilham Hmid ◽  
Driss Elothmani ◽  
Hafida Hanine ◽  
Ahmed Oukabli ◽  
Emira Mehinagic
Keyword(s):  
Phenolic Compounds ◽  
Comparative Study ◽  
Punica Granatum ◽  
Punica Granatum L
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