scholarly journals Germline Genetics in Colorectal Cancer Susceptibility and Prognosis

10.5772/27222 ◽  
2012 ◽  
Author(s):  
Amanda Ewart
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility

The association of a genetic variant in multi-drug resistance gene and colorectal cancer susceptibility

Gene Reports ◽  
2021 ◽  
pp. 101252
Author(s):  
Forouzan Amerizadeh ◽  
Mehrdad Moetamani-Ahmadi ◽  
Soodabeh Shahidsales ◽  
Farzad Rahmani ◽  
Masoumeh Gharib ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Resistance Gene ◽  
Genetic Variant ◽  
Cancer Susceptibility ◽  
Multi Drug Resistance ◽  
Drug Resistance Gene

scholarly journals Association Between Colorectal Cancer Susceptibility Loci and Survival Time After Diagnosis With Colorectal Cancer

2012 ◽  
Vol 143 (1) ◽  
pp. 51-54.e4 ◽  
Author(s):  
Amanda I. Phipps ◽  
Polly A. Newcomb ◽  
Xabier Garcia–Albeniz ◽  
Carolyn M. Hutter ◽  
Emily White ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Time ◽  
Cancer Susceptibility ◽  
Susceptibility Loci

Colorectal cancer susceptibility loci and influence on survival

2018 ◽  
Vol 57 (12) ◽  
pp. 630-637 ◽  
Author(s):  
Nan Song ◽  
Kyeezu Kim ◽  
Aesun Shin ◽  
Ji Won Park ◽  
Hee Jin Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Loci

scholarly journals Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes

2017 ◽  
Vol 5 (5) ◽  
pp. 553-569 ◽  
Author(s):  
Melissa S. DeRycke ◽  
Shanaka Gunawardena ◽  
Jessica R. Balcom ◽  
Angela M. Pickart ◽  
Lindsey A. Waltman ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Targeted Sequencing ◽  
Cancer Susceptibility Genes

scholarly journals Relevance of hMLH1 -93G>A, 655A>G and 1151T>A polymorphisms with colorectal cancer susceptibility: a meta-analysis based on 38 case-control studies

2018 ◽  
Vol 64 (10) ◽  
pp. 942-951 ◽  
Author(s):  
Mohammad Zare ◽  
Jamal Jafari-Nedooshan ◽  
Mohammadali Jafari ◽  
Hossein Neamatzadeh ◽  
Seyed Mojtaba Abolbaghaei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Biomedical Literature ◽  
Case Control Studies ◽  
Increased Risk ◽  
Comprehensive Search ◽  
Meta Analyses

SUMMARY OBJECTIVE: There has been increasing interest in the study of the association between human mutL homolog 1 (hMLH1) gene polymorphisms and risk of colorectal cancer (CRC). However, results from previous studies are inconclusive. Thus, a meta-analysis was conducted to derive a more precise estimation of the effects of this gene. METHODS: A comprehensive search was conducted in the PubMed, EMBASE, Chinese Biomedical Literature databases until January 1, 2018. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. RESULTS: Finally, 38 case-control studies in 32 publications were identified met our inclusion criteria. There were 14 studies with 20668 cases and 19533 controls on hMLH1 −93G>A, 11 studies with 5,786 cases and 8,867 controls on 655A>G and 5 studies with 1409 cases and 1637 controls on 1151T>A polymorphism. The combined results showed that 655A>G and 1151T>A polymorphisms were significantly associated with CRC risk, whereas −93G>A polymorphism was not significantly associated with CRC risk. As for ethnicity, −93G>A and 655A>G polymorphisms were associated with increased risk of CRC among Asians, but not among Caucasians. More interestingly, subgroup analysis indicated that 655A>G might raise CRC risk in PCR-RFLP and HB subgroups. CONCLUSION: Inconsistent with previous meta-analyses, this meta-analysis shows that the hMLH1 655A>G and 1151T>A polymorphisms might be risk factors for CRC. Moreover, the −93G>A polymorphism is associated with the susceptibility of CRC in Asian population.

Association of eNOS polymorphisms (-786T>C, 4a4b, 894G>T) with colorectal cancer susceptibility in the Korean population

Gene ◽  
2013 ◽  
Vol 512 (2) ◽  
pp. 275-281 ◽  
Author(s):  
Moon Ju Jang ◽  
Young Joo Jeon ◽  
Jong Woo Kim ◽  
So Young Chong ◽  
Sung Pyo Hong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Korean Population ◽  
Enos Polymorphisms
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