scholarly journals Mouse Models of Chronic Lymphocytic Leukemia

10.5772/27091 ◽  
2012 ◽  
Author(s):  
Gema Prez-Chacn ◽  
Juan M.
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Models ◽  
Lymphocytic Leukemia

scholarly journals Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia

Oncotarget ◽  
2018 ◽  
Vol 9 (41) ◽  
pp. 26353-26369 ◽  
Author(s):  
Joachim R. Göthert ◽  
Roze Imsak ◽  
Michael Möllmann ◽  
Stefanie Kesper ◽  
Maria Göbel ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Models ◽  
Lymphocytic Leukemia ◽  
Cyclin Dependent Kinase

scholarly journals Inhibition of chronic lymphocytic leukemia progression by full-length chromogranin A and its N-terminal fragment in mouse models

Oncotarget ◽  
2016 ◽  
Vol 7 (27) ◽  
pp. 41725-41736 ◽  
Author(s):  
Mimma Bianco ◽  
Anna Gasparri ◽  
Luca Generoso ◽  
Emma Assi ◽  
Barbara Colombo ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Models ◽  
Chromogranin A ◽  
Lymphocytic Leukemia ◽  
Full Length ◽  
Terminal Fragment

scholarly journals Bertilaccio MT, Simonetti G, Dagklis A, et al. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood. 2011;118(3):660–669.

Blood ◽  
2012 ◽  
Vol 120 (13) ◽  
pp. 2773-2773
Author(s):  
Maria Teresa Sabrina Bertilaccio ◽  
Giorgia Simonetti ◽  
Antonis Dagklis ◽  
Martina Rocchi ◽  
Tania Veliz Rodriguez ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Models ◽  
Lymphocytic Leukemia

scholarly journals Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Gero Knittel ◽  
Tim Rehkämper ◽  
Darya Korovkina ◽  
Paul Liedgens ◽  
Christian Fritz ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Models ◽  
Lymphocytic Leukemia

scholarly journals Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy

Blood ◽  
2014 ◽  
Vol 124 (7) ◽  
pp. 1010-1019 ◽  
Author(s):  
Giorgia Simonetti ◽  
Maria Teresa Sabrina Bertilaccio ◽  
Paolo Ghia ◽  
Ulf Klein
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Models ◽  
Human Disease ◽  
Molecular Mechanisms ◽  
Genetically Engineered ◽  
Lymphocytic Leukemia ◽  
Genetically Engineered Mouse Models ◽  
Receptor Repertoire ◽  
Human Malignancy ◽  
Species Specific

Abstract Mouse models that recapitulate human malignancy are valuable tools for the elucidation of the underlying pathogenetic mechanisms and for preclinical studies. Several genetically engineered mouse models have been generated, either mimicking genetic aberrations or deregulated gene expression in chronic lymphocytic leukemia (CLL). The usefulness of such models in the study of the human disease may potentially be hampered by species-specific biological differences in the target cell of the oncogenic transformation. Specifically, do the genetic lesions or the deregulated expression of leukemia-associated genes faithfully recapitulate the spectrum of lymphoproliferations in humans? Do the CLL-like lymphoproliferations in the mouse have the phenotypic, histological, genetic, and clinical features of the human disease? Here we compare the various CLL mouse models with regard to disease phenotype, penetrance, and severity. We discuss similarities and differences of the murine lymphoproliferations compared with human CLL. We propose that the Eμ-TCL1 transgenic and 13q14-deletion models that have been comprehensively studied at the levels of leukemia phenotype, antigen-receptor repertoire, and disease course show close resemblance to the human disease. We conclude that modeling CLL-associated genetic dysregulations in mice can provide important insights into the molecular mechanisms of disease pathogenesis and generate valuable tools for the development of novel therapies.

scholarly journals The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia

2016 ◽  
Vol 23 (11) ◽  
pp. 2831-2841 ◽  
Author(s):  
Sarah E.M. Herman ◽  
Arnau Montraveta ◽  
Carsten U. Niemann ◽  
Helena Mora-Jensen ◽  
Michael Gulrajani ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Tyrosine Kinase ◽  
Mouse Models ◽  
Lymphocytic Leukemia ◽  
Bruton Tyrosine Kinase ◽  
Btk Inhibitor ◽  
Target Effects
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