scholarly journals Silver Nanoparticles – Universal Multifunctional Nanoparticles for Bio Sensing, Imaging for Diagnostics and Targeted Drug Delivery for Therapeutic Applications

10.5772/27047 ◽  
2011 ◽  
Author(s):  
Anitha Sironmani ◽  
Kiruba Daniel
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Targeted Drug Delivery ◽  
Multifunctional Nanoparticles ◽  
Therapeutic Applications ◽  
Targeted Drug

Recent advances in combinatorial cancer therapy via multifunctionalized gold nanoparticles

Nanomedicine ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. 1221-1237
Author(s):  
Touqeer Ahmad ◽  
Rizwana Sarwar ◽  
Ayesha Iqbal ◽  
Uzma Bashir ◽  
Umar Farooq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Therapeutic Implications ◽  
Therapeutic Applications ◽  
Diagnosis Of Cancer ◽  
Targeted Drug ◽  
Cancerous Cells

The diverse behavior of nanogold in the therapeutic field is related to its unique size and shape. Nanogold offers improvements in modern diagnostic and therapeutic implications, increases disease specificity and targeted drug delivery, and is relatively economical compared with other chemotherapeutic protocols. The diagnosis of cancer and photothermal therapy improve drastically with the implementation of nanotechnology. Different types of nanoparticles, that is, gold silica nanoshells, nanorods and nanospheres of diverse shapes and geometries, are used widely in the photothermal therapy of cancerous cells and nodules. Numerous reviews have been published on the therapeutic applications of gold nanoparticles, but studies on combinatorial applications of nanogold in cancer therapy are limited. This review focuses on the combinatorial cancer therapy using optical properties of nanogold with different shapes and geometries, and their therapeutic applications in cancer diagnosis, photothermal therapy, cancer imaging and targeted drug delivery.

scholarly journals Plant-Mediated Synthesis of Silver Nanoparticles – A Critical Review

2018 ◽  
Vol 9 (07) ◽  
Author(s):  
Sneha Thakur ◽  
Krishna Mohan G. ◽  
Sandhya Rani M.
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Raman Scattering ◽  
Targeted Drug Delivery ◽  
Critical Review ◽  
Thermo Gravimetric Analysis ◽  
Gravimetric Analysis ◽  
Potential Measurement ◽  
Capping Agents ◽  
Targeted Drug

Nanomedicine is a revolutionary science nanoparticles of size 1 - 100nm designed for the utilization in disease diagnostics and therapeutics, targeted drug delivery of drugs which have difficulty in solubility and bioavailability and also to be applied in numerous fields. The present critical review aims at enumerating the advantages, synthesis and characterization methods, as well as diversified applications of green silver nanoparticles. Silver nanoparticles is an attractive proposition due to their distinctive physical, chemical and biological properties including a high electrical as well as thermal conductivity, surface-enhanced Raman scattering, chemical stability, catalytic activity and non linear optical behavior which enables them of potential value in inks, microelectronics, and medical imaging. Plant mediated synthesis of silver nanoparticles (AgNPs) is now-a-day’s gaining enormous interest as it is cost effective, ecofriendly and has less side effects since there is no addition of external stabilizing or capping agents as the plant itself acts as stabilizing or capping agent. The secondary metabolites and other plant products like proteins, metabolites like alkaloids, terpinoids, saponins, glycosides etc are known to act as external stabilizing or capping agents. The plant mediated silver nanoparticles are known to show uniform particles characteristics and morphology. The bottom to top end approach of synthesis is effective to achieve desired particles size, shape and morphology. The synthesized green silver nanoparticles are characterized by UVVis spectroscopy, SEM/TEM analysis, EDAX/EDS, FTIR and other methods zeta potential measurement, thermo gravimetric analysis, Raman scattering. The plant mediated synthesized silver nanoparticles (green silver nanoparticles) are effective in delivering pharmacological activities like antimicrobial, anticancer, larvicidal etc. Also green Silver nanoparticles have diverse applications acting as biosensors, as targeted drug delivery candidates, in diagnostics and therapeutics, in medical and consumer products, as anti pollutant and in agriculture. The future perspective holds promising results in green synthesis of silver nanoparticles involving plants. This review projects a collective sequence of information for synthesizing and evaluation of green silver nanoparticles and scope of its pharmacological actions.

Potential Bactericidal Activity of Silver Nanoparticles

MRS Advances ◽  
2020 ◽  
Vol 5 (18-19) ◽  
pp. 975-984
Author(s):  
David Medina Suárez ◽  
Jousen A. Merced Colón ◽  
Waldemar García-Mercado ◽  
Dalice Piñero-Cruz ◽  
Sonia J. Bailón-Ruiz
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Bactericidal Activity ◽  
Targeted Drug Delivery ◽  
Food Packaging ◽  
Pathogenic Bacteria ◽  
Micrococcus Luteus ◽  
Bacterial Strains ◽  
Ag Nps ◽  
Targeted Drug

ABSTRACTIn recent times, nanotechnology has drawn the attention of the scientific community because of the wide variety of applications that can be done with it, from food packaging to targeted drug delivery; the use of nanoparticles has been a breakthrough in science that has now reached the market. Silver nanoparticles (Ag NPs) have unique properties due to the oscillation of electrons in the superficial plasmon. These nanostructures have been used in different applications in the area of nanomedicine, such as: targeted drug delivery, sensing and imaging, anti-fungal, anti-cancerous and biosensors. It has become evident that pathogenic bacteria are resisting antibiotics such as Penicillin becoming one of the most worrying topics in the world. People in the science community fear the day when we no longer can use these antibiotics, because the resistance of bacteria became too great, leaving us defenceless against any type of pathogens and possibly causing a catastrophe. However, we theorize that the possible solution to this problem could be the use of silver nanoparticles, given that there has not been a documented bacterial adaptation strategy that could give them resistance to Ag NPs. The purpose of this study is to find how the water-stable silver nanoparticles interact with different strains, including Gram negative and Gram-positive bacteria. The main objectives of our research were to synthesize and characterize water stable silver nanoparticles and test their potential bactericidal activity. We synthesized our Ag NPs using sodium citrate as a reducing agent. After synthesizing the nanoparticles, their optical properties were characterized by Ultraviolet-visible spectroscopy (UV-Vis); crystalline structure was evaluated with Electron Diffraction (ED) and X-Ray Diffraction (XRD); morphology was assessed by High Resolution Transmission Electron Microscopy (HR-TEM). Fourier Transform Infra-Red Spectroscopy (FT-IR) was used to indicate functional groups involved in the nanoparticle capping. Cultures were prepared with agarose and inoculated with the following bacterial strains: Bacillus cereus (Gram +), Micrococcus luteus (Gram +), Staphylococcus aureus (Gram +), Escherichia coli (Gram -), Citrobacter freundii (Gram -), Enterobacter aerogenes (Gram -), Klebsiella pneumoniae (Gram -), Proteus mirabilis (Gram -), Proteus vulgaris (Gram -) and Serratia marcescens (Gram -). Preliminary tests showed an inhibition diameter that surpassed 1.0 cm in all bacterial strains. We expect our Ag NPs to have a potential antibacterial activity towards all types of bacteria, due to oxidation of silver (Ag0 to Ag+).

scholarly journals Peptide-functionalized gold nanoparticles: versatile biomaterials for diagnostic and therapeutic applications

2017 ◽  
Vol 5 (5) ◽  
pp. 872-886 ◽  
Author(s):  
Jingyi Zong ◽  
Steven L. Cobb ◽  
Neil R. Cameron
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Targeted Drug Delivery ◽  
Potential Application ◽  
Cancer Therapeutics ◽  
Therapeutic Applications ◽  
Functionalized Gold Nanoparticles ◽  
Anti Cancer ◽  
Targeted Drug ◽  
Oligonucleotide Delivery

This review provides an overview of the current methods used for preparing peptide-functionalized GNPs, and discusses the key properties of this class of biomaterial. In particular, their potential application in areas of sensing, targeted drug delivery, anti-cancer therapeutics and oligonucleotide delivery are discussed.

Bioinspired Smart Nanosystems in Advanced Therapeutic Applications

2019 ◽  
Vol 7 (3) ◽  
pp. 246-256 ◽  
Author(s):  
Satya Prakash Singh ◽  
Anup Kumar Sirbaiya ◽  
Anuradha Mishra
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Biologically Active ◽  
Therapeutic Applications ◽  
Target Sites ◽  
External Conditions ◽  
Targeted Drug ◽  
Smart Drug ◽  
Smart Drug Delivery ◽  
Targeted Drug Delivery Systems

Background: Nanoparticle technologies used for human administration must be designed to interact with a living host environment. The idea about bioinspired smart drug delivery carriers includes the development of biocompatible nanomaterials which can be further loaded with the drug for specific targeted drug delivery applications. Objective: Biosmart nanosystems are used for several applications in the delivery of drugs and pharmaceuticals for their therapeutic applications like biological markers, diagnostic purposes such as imaging applications and also for gene therapy. Thus, the bioinspired nanocarriers are capable of carrying biologically active molecules to the target sites. This bioinspired nanosystem constitutes of lipids, polymers and biomaterials which utilizes various responsive sensors for targeted drug delivery systems. However, external conditions such as heat, light, magnetic or electric field and ultrasounds, along with temperature, altered pH and ionic strength can affect the bioinspired smart nanosystem for drug delivery. Conclusion: The present review focuses on challenges for the development of bioinspired smart nanocarriers for the management of various disorders.

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