scholarly journals Metabolic Modulators to Treat Cardiac Arrhythmias Induced by Ischemia and Reperfusion

Tachycardia ◽  
10.5772/26894 ◽  
2012 ◽  
Author(s):  
Moslem Najafi ◽  
Tahereh Eteraf-Oskouei
Keyword(s):  
Cardiac Arrhythmias ◽  
Ischemia And Reperfusion

scholarly journals Cardioprotection stimulated by resveratrol and grape products prevents lethal cardiac arrhythmias in an animal model of ischemia and reperfusion

2021 ◽  
Vol 36 (3) ◽  
Author(s):  
Francisco Sandro Menezes-Rodrigues ◽  
Paolo Ruggero Errante ◽  
Erisvaldo Amarante Araújo ◽  
Mariana Pontes Pacheco Fernandes ◽  
Michele Mendes da Silva ◽  
...  
Keyword(s):  
Animal Model ◽  
Cardiac Arrhythmias ◽  
Ischemia And Reperfusion

A direct role of endogenous prostaglandins in reperfusion-induced cardiac arrhythmias

1989 ◽  
Vol 67 (7) ◽  
pp. 772-779 ◽  
Author(s):  
Margaret P. Moffat ◽  
Gregory R. Ferrier ◽  
Morris Karmazyn
Keyword(s):  
Cardiac Arrhythmias ◽  
Ischemia Reperfusion ◽  
Ischemia And Reperfusion ◽  
Early Repolarization ◽  
Direct Role ◽  
Purkinje Fibres ◽  
Endogenous Prostaglandins ◽  
Pg Release

The possible role of prostaglandins (PG) in arrhythmias associated with ischemia and reperfusion was studied in isolated, superfused canine Purkinje tissues. Ischemic conditions caused partial depolarization and decrease of excitability. Neither inhibition of PG synthesis (ibuprofen, 30 μg/mL) nor addition of exogenous PGF2α (1 ng/mL) modified responses to "ischemia." Reperfusion with normal Tyrode's solution stimulated PG production (measured as 6-keto-PGF1α) and induced a series of electrophysiological events. Under control conditions, Purkinje fibres rapidly repolarized. Subsequently, these tissues began to depolarize and oscillatory afterpotentials appeared. Purkinje tissues depolarized further and became temporarily inexcitable. Return of activity was associated with depolarization-induced automaticity. Ibuprofen prevented reperfusion-stimulated PG release. Ibuprofen also increased the magnitude of early repolarization and greatly attenuated subsequent depolarization. Depolarization-induced automaticity was not observed under these conditions; however, oscillatory afterpotentials were not abolished by ibuprofen. Addition of PGF2α to "ischemic" and reperfusion solutions in the presence of ibuprofen restored the arrhythmogenic responses. We conclude that release of endogenous prostaglandins contributes to electrophysiological changes elicited by reperfusion in canine Purkinje fibres.Key words: arrhythmias, ischemia, reperfusion, ibuprofen, prostaglandins.

Sleep and cardiac arrhythmias

1972 ◽  
Vol 130 (5) ◽  
pp. 751-753 ◽  
Author(s):  
R. Smith
Keyword(s):  
Cardiac Arrhythmias
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