scholarly journals Diagnostic Approach in Acute Myeloid Leukemias in Line with WHO 2008 Classification

10.5772/26745 ◽  
2012 ◽  
Author(s):  
Manu Goyal ◽  
K. Gayathri
Keyword(s):  
Diagnostic Approach ◽  
Myeloid Leukemias ◽  
Acute Myeloid ◽  
Who 2008

Expression pattern of the septin gene family in acute myeloid leukemias with and without MLL-SEPT fusion genes

2010 ◽  
Vol 34 (5) ◽  
pp. 615-621 ◽  
Author(s):  
Joana Santos ◽  
Nuno Cerveira ◽  
Susana Bizarro ◽  
Franclim R. Ribeiro ◽  
Cecília Correia ◽  
...  
Keyword(s):  
Gene Family ◽  
Expression Pattern ◽  
Fusion Genes ◽  
Myeloid Leukemias ◽  
Acute Myeloid

The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0

2010 ◽  
Vol 91 (2) ◽  
pp. 303-309 ◽  
Author(s):  
Ritsuro Suzuki ◽  
Shigeki Ohtake ◽  
Jin Takeuchi ◽  
Masami Nagai ◽  
Yoshihisa Kodera ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Unrelated clonal chromosome abnormalities in myelodysplastic syndromes and acute myeloid leukemias

2002 ◽  
Vol 132 (2) ◽  
pp. 156-158 ◽  
Author(s):  
Jin-Yeong Han ◽  
Kyeong-Hee Kim ◽  
Hyuk-Chan Kwon ◽  
Jae-Seok Kim ◽  
Hyo-Jin Kim ◽  
...  
Keyword(s):  
Myelodysplastic Syndromes ◽  
Chromosome Abnormalities ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Acute Myeloid Leukemias

2007 ◽  
pp. 767-775
Author(s):  
Iris T. Chan ◽  
D. Gary Gilliland
Keyword(s):  
Myeloid Leukemias ◽  
Acute Myeloid

scholarly journals CLL dedifferentiation to clonally related myeloid cells

2020 ◽  
Vol 4 (24) ◽  
pp. 6169-6174
Author(s):  
Qianze Dong ◽  
Yan Xiu ◽  
Aaron Bossler ◽  
Sergei Syrbu ◽  
Hongming Wang ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Progenitor Cells ◽  
Myeloid Cells ◽  
Lymphocytic Leukemia ◽  
Key Points ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Key Points Common progenitor cells exist in clonally related concomitant chronic lymphocytic leukemia and acute myeloid leukemias. CLL cells dedifferentiated to clonally related myeloid cells posttransplantation.

scholarly journals Database-Guided Analysis for Immunophenotypic Diagnosis and Follow-Up of Acute Myeloid Leukemia With Recurrent Genetic Abnormalities

2021 ◽  
Vol 11 ◽  
Author(s):  
Carmen-Mariana Aanei ◽  
Richard Veyrat-Masson ◽  
Cristina Selicean ◽  
Mirela Marian ◽  
Lauren Rigollet ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Residual Disease ◽  
Hematologic Malignancies ◽  
Multicolor Flow Cytometry ◽  
Phenotypic Differences ◽  
Molecular Tests ◽  
Genetic Abnormalities ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Acute myeloid leukemias (AMLs) are hematologic malignancies with varied molecular and immunophenotypic profiles, making them difficult to diagnose and classify. High-dimensional analysis algorithms might increase the utility of multicolor flow cytometry for AML diagnosis and follow-up. The objective of the present study was to assess whether a Compass database-guided analysis can be used to achieve rapid and accurate diagnoses. We conducted this study to determine whether this method could be employed to pilote the genetic and molecular tests and to objectively identify different-from-normal (DfN) patterns to improve measurable residual disease follow-up in AML. Three Compass databases were built using Infinicyt 2.0 software, including normal myeloid-committed hematopoietic precursors (n = 20) and AML blasts harboring the most frequent recurrent genetic abnormalities (n = 50). The diagnostic accuracy of the Compass database-guided analysis was evaluated in a prospective validation study (125 suspected AML patients). This method excluded AML associated with the following genetic abnormalities: t(8;21), t(15;17), inv(16), and KMT2A translocation, with 92% sensitivity [95% confidence interval (CI): 78.6%–98.3%] and a 98.5% negative predictive value (95% CI: 90.6%–99.8%). Our data showed that the Compass database-guided analysis could identify phenotypic differences between AML groups, representing a useful tool for the identification of DfN patterns.

Acute Myeloid Leukemias with Myelodysplasia-related Changes

2018 ◽  
pp. 327-333
Author(s):  
Faramarz Naeim ◽  
P. Nagesh Rao ◽  
Sophie X. Song ◽  
Ryan T. Phan
Keyword(s):  
Myeloid Leukemias ◽  
Acute Myeloid
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