scholarly journals Ulcerative Colitis and Colorectal Cancer: Aneuploidy and Implications for Improved Screening

10.5772/26466 ◽  
2012 ◽  
Author(s):  
Jens K. ◽  
Gert Auer ◽  
Thomas Ried ◽  
Uwe J.
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis

Deletion mapping on chromosome 6 in colorectal cancer associated with ulcerative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A121-A122
Author(s):  
T EZAKI ◽  
M WATANABE ◽  
S FUNAKOSHI ◽  
M NAGANUMA ◽  
T AZUMA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Deletion Mapping ◽  
Chromosome 6

Colorectal cancer in patients with ulcerative colitis. A prospective cohort study in Italy

Cancer ◽  
1995 ◽  
Vol 75 (8) ◽  
pp. 2045-2050 ◽  
Author(s):  
Guido Biasco ◽  
Giovanni Brandi ◽  
Gian Maria Paganelli ◽  
Francesco Paolo Rossini ◽  
Renato Santucci ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort

Familial predisposition for colorectal cancer in chronic ulcerative colitis: A case-control study

1998 ◽  
Vol 115 (5) ◽  
pp. 1079-1083 ◽  
Author(s):  
K NUAKO ◽  
D AHLQUIST ◽  
D MAHONEY ◽  
D SCHAID ◽  
D SIEMS ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Chronic Ulcerative Colitis ◽  
Case Control Study ◽  
Case Control ◽  
Familial Predisposition ◽  
Control Study

A case of colorectal cancer associated with ulcerative colitis

2021 ◽  
Vol 98 (1) ◽  
pp. 110-112
Author(s):  
Mitsuhiro Nakao ◽  
Osamu Ikezaki ◽  
Tomoya Hiratsuka ◽  
Mayumi Ide ◽  
Ryusuke Shimada ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis

scholarly journals Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Zhiqi Wang ◽  
Sai Li ◽  
Yu Cao ◽  
Xuefei Tian ◽  
Rong Zeng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Carbonyl Compounds ◽  
Gene Mutations ◽  
Oxygen Species ◽  
Inflammatory Conditions ◽  
Dna Mutations ◽  
Pathogenic Factors ◽  
Protein Dysfunction

Oxidative stress has long been known as a pathogenic factor of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC), but the effects of secondary carbonyl lesions receive less emphasis. In inflammatory conditions, reactive oxygen species (ROS), such as superoxide anion free radical (O2∙-), hydrogen peroxide (H2O2), and hydroxyl radical (HO∙), are produced at high levels and accumulated to cause oxidative stress (OS). In oxidative status, accumulated ROS can cause protein dysfunction and DNA damage, leading to gene mutations and cell death. Accumulated ROS could also act as chemical messengers to activate signaling pathways, such as NF-κB and p38 MAPK, to affect cell proliferation, differentiation, and apoptosis. More importantly, electrophilic carbonyl compounds produced by lipid peroxidation may function as secondary pathogenic factors, causing further protein and membrane lesions. This may in turn exaggerate oxidative stress, forming a vicious cycle. Electrophilic carbonyls could also cause DNA mutations and breaks, driving malignant progression of UC. The secondary lesions caused by carbonyl compounds may be exceptionally important in the case of host carbonyl defensive system deficit, such as aldo-keto reductase 1B10 deficiency. This review article updates the current understanding of oxidative stress and carbonyl lesions in the development and progression of UC and CAC.

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