scholarly journals Role of Cytomegalovirus Reinfection in Acute Rejection and CMV Disease After Renal Transplantation

10.5772/26285 ◽  
2012 ◽  
Author(s):  
Kei Ishibashi ◽  
Tatsuo Suzutani
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Cmv Disease

scholarly journals Effectiveness of Valganciclovir 900mg Versus 450mg for Cytomegalovirus Prophylaxis in Renal Transplantation: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 20 ◽  
pp. 168 ◽  
Author(s):  
Wang Xin ◽  
Yang Hui ◽  
Zhang Xiaodong ◽  
Cui Xiangli ◽  
Wang Shihui ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Low Dose ◽  
Opportunistic Infections ◽  
Meta Analysis ◽  
High Dose ◽  
Renal Transplant Recipients ◽  
Significant Difference ◽  
Allograft Loss ◽  
Cmv Disease

Objectives: Valganciclovir 900 mg/day is approved for cytomegalovirus (CMV) prophylaxis, but 450 mg/day is seems also effective. We systematically reviewed the efficacy and safety of low-dose versus high-dose valganciclovir prophylaxis in renal transplantation recipients. Methods: An electronic search was conducted up to November 29, 2016. The primary outcomes were incidences of CMV, CMV disease, mortality and opportunistic infection. The second outcomes were acute rejection, allograft loss, adverse drug reaction (ADR). Results: 7 cohort studies, all with high quality involving (1431 patients) were included. There was no significant difference of the incidence of following CMV disease (1271 patients, odds ratio [OR] 0.74, 95% confidence interval [CI], 0.38-1.43, p=0.36), acute rejection (1343 patients, OR 0.77, 95%CI 0.53-1.14, p=0.19), allograft loss (1271 patients, OR 0.64, 95%CI 0.31-1.35, p=0.24), mortality (1271 patients, OR 0.55, 95%CI 0.20-1.47, p=0.23) and opportunistic infections (OI) (985 patients, OR 0.76, 95%CI 0.52-1.10, p=0.14) between the low-dose and the high-dose valganciclovir  prophylaxis. And no significant difference was observed for premature valganciclovir discontinuation (1010 patients, OR 0.81, 95%CI 0.52-1.25, p=0.33) and the incidence of leukopenia (1082 patients, OR 0.65, 95%CI 0.34-1.22, p=0.18) between the two regimens. Conclusion: 450 mg and 900 mg doses of valganciclovir are equipotent for CMV universal prophylaxis. CMV 450 mg prophylaxis should be used for renal transplant recipients. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection

2008 ◽  
Vol 456 (6) ◽  
pp. 1075-1084 ◽  
Author(s):  
Stefan Reuter ◽  
Ana Velic ◽  
Bayram Edemir ◽  
Rita Schröter ◽  
Hermann Pavenstädt ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Protective Role ◽  
Rat Renal Transplantation

The Role of KIR2DS4 Polymorphisms in BK Virus and Acute Rejection Following Renal Transplantation

2018 ◽  
Vol 102 ◽  
pp. S224 ◽  
Author(s):  
Patrick Trotter ◽  
Jessica Padley ◽  
Keziah Crick ◽  
Jyothi Jayaraman ◽  
James Traherne ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Bk Virus

88 ROLE OF RESISTIVE INDEX MEASUREMENT IN DIAGNOSIS OF ACUTE REJECTION AFTER RENAL TRANSPLANTATION

2009 ◽  
Vol 8 (4) ◽  
pp. 142
Author(s):  
A.R. Mehrsai ◽  
D. Mansoori ◽  
M. Taherimahmoudi ◽  
Danesh M. Rezaei ◽  
H. Wahhabaghai ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Resistive Index ◽  
Index Measurement

Effect of Pre-Transplant Dialysis Modality on Kidney Transplantation Outcome

2009 ◽  
Vol 29 (2_suppl) ◽  
pp. 117-122 ◽  
Author(s):  
Yasar Caliskan ◽  
Halil Yazici ◽  
Numan Gorgulu ◽  
Berna Yelken ◽  
Turker Emre ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Bacterial Infections ◽  
Graft Function ◽  
Human Leukocyte ◽  
Control Group ◽  
Dialysis Modality ◽  
Post Transplant ◽  
Early Graft ◽  
Cmv Disease

Background The effect of pre-transplant dialysis modality on early graft function is a matter of debate. Although some authors deny the existence of a significant influence, others suggest that peritoneal dialysis (PD) affects early graft function favorably, possibly by contributing to a more physiologic water balance. In the present study, we evaluated the influence of pre-transplant dialysis modality on early and late graft function. Patients and Methods We studied 745 patients who underwent a first renal transplantation during 1983 – 2006, comparing the records of 44 PD patients [26 male; mean age: 26 ± 9 years (range: 8 – 56 years)] who received 36 living related and 8 cadaveric renal transplantations with those of a control group of 44 consecutive hemodialysis (HD) patients [26 male; mean age: 27 ± 11 years (range: 7 – 49 years)] for the index cases. Results The groups showed no significant differences in donor type, human leukocyte antigen matching, immunosuppressive protocols, and duration of dialysis. Also, neither group differed significantly with regard to incidence of delayed graft function, acute tubular necrosis, wound infection, systemic viral and bacterial infections, or acute rejection in the early post-transplant period. In the late post-transplant period, incidences of chronic rejection, graft failure, and malignancies were also similar. During the follow-up period, 3 patients in the PD group experienced acute rejection, 2 developed cytomegalovirus (CMV) disease, and 5 developed various other infections. In the HD group, 4 patients experienced acute rejection, 1 developed CMV disease, and 8 experienced other infections. Five patients in the PD group and one in the HD group died with functioning grafts ( p = 0.09). No differences were noted between the groups in the incidences of post-transplant cardiovascular complications, malignancies, and diabetes mellitus. In the PD group, 33 patients with functioning grafts are still being followed, 6 have returned to dialysis, and 5 have died. In the HD group, 38 patients with functioning grafts are still being followed, 5 have returned to dialysis, and 1 has died. Conclusions As a pre-transplant dialysis modality, neither HD nor PD affects the outcome of renal transplantation.

Role of Cold Ischemia in Acute Rejection: Characterization of a Humoral-Like Acute Rejection in Experimental Renal Transplantation

2005 ◽  
Vol 37 (9) ◽  
pp. 3712-3715 ◽  
Author(s):  
I. Herrero-Fresneda ◽  
M. Franquesa ◽  
J. Torras ◽  
A. Vidal ◽  
J. Aran ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Cold Ischemia

Factors Contributing to Acute Rejection in Renal Transplantation: The Role of Noncompliance

2005 ◽  
Vol 37 (5) ◽  
pp. 2044-2047 ◽  
Author(s):  
P.E. Morrissey ◽  
S. Reinert ◽  
A. Yango ◽  
A. Gautam ◽  
A. Monaco ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection

1625: Reinfection of Cytomegalovirus with Different Strain from Donors is a Major Cause of Acute Rejection in Renal Transplantation

2005 ◽  
Vol 173 (4S) ◽  
pp. 440-440
Author(s):  
Kei Ishibashi ◽  
Tomohiko Yanagida ◽  
Tadahiko Tokumoto ◽  
Kazunari Tanabe ◽  
Hiraki Shirakawa ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection

Role of Oxidative Stress in Renal Transplantation: Bases for an n-3 PUFA Strategy Against Delayed Graft Function

2017 ◽  
Vol 24 (14) ◽  
Author(s):  
Camilo G. Sotomayor ◽  
Ignacio Cortés ◽  
Juan Guillermo Gormaz ◽  
Sergio Vera ◽  
Matías Libuy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplantation ◽  
Graft Function ◽  
Delayed Graft Function
Sign in / Sign up

Export Citation Format

Share Document