scholarly journals Distinct Inhibitory Effect of TGFβ on the Growth of Human Myeloid Leukemia Cells

10.5772/26211 ◽  
2011 ◽  
Author(s):  
Xiao Tang
Keyword(s):  
Myeloid Leukemia ◽  
Inhibitory Effect ◽  
Leukemia Cells

scholarly journals The Inhibitory Effect of Human Macrophage Inflammatory Protein‐1α (LD78) on Acute Myeloid Leukemia Cells in Vitro

Stem Cells ◽  
1996 ◽  
Vol 14 (4) ◽  
pp. 445-451 ◽  
Author(s):  
Nadežda Basara ◽  
Stanislava Stošić‐Gruji&c ◽  
Dijana Šefer ◽  
Zoran Ivanović ◽  
Petar Antunović ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Inhibitory Effect ◽  
Leukemia Cells ◽  
Human Macrophage ◽  
Inflammatory Protein ◽  
Acute Myeloid Leukemia Cells ◽  
Macrophage Inflammatory Protein ◽  
Acute Myeloid

Anti-CD38 antibody–mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

Blood ◽  
2008 ◽  
Vol 112 (3) ◽  
pp. 568-575 ◽  
Author(s):  
David C. Taussig ◽  
Farideh Miraki-Moud ◽  
Fernando Anjos-Afonso ◽  
Daniel J. Pearce ◽  
Kirsty Allen ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cord Blood ◽  
Myeloid Leukemia ◽  
Inhibitory Effect ◽  
Leukemia Cells ◽  
Present Evidence ◽  
Immunodeficient Mice ◽  
Potential Pitfall ◽  
Rare Cells ◽  
Acute Myeloid

Abstract Immunodeficient mice are increasingly used to assay human hematopoietic repopulating cells as well as leukemia-initiating cells. One method commonly used to isolate these rare cells is to sort cells stained with fluorochrome-conjugated antibodies into fractions, then transplant the different fractions into immunodeficient mice to test their repopulating ability. The antibodies are generally treated as being neutral in terms of their effects on the experiment. Human repopulating cells are thought to express CD34 and lack CD38. Here we present evidence that anti-CD38 antibodies have a profound inhibitory effect on engraftment of cord blood and leukemia cells. We show that this effect is Fc-mediated and can be overcome by treating mice with immunosuppressive antibodies. When this inhibitory effect is prevented, we demonstrate that the CD34+CD38+ fraction of certain acute myeloid leukemia samples contains all, or at least most, leukemia-initiating cell capacity. This study highlights the potential pitfall of antibody-mediated clearance of repopulating cells and is important for any groups working with this model. More importantly, the work suggests that there is greater variation in the phenotypes of leukemia-initiating cells than previously suggested.

Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro

1991 ◽  
Vol 15 (10) ◽  
pp. 883-886 ◽  
Author(s):  
Shounan Yi ◽  
Jane Wass ◽  
Paul Vincent ◽  
Harry Iland
Keyword(s):  
Myeloid Leukemia ◽  
Inhibitory Effect ◽  
Leukemia Cells

Differentiation of myeloid leukemia cells by HDAC-inhibitors

2004 ◽  
Vol 216 (03) ◽  
Author(s):  
S Schulze ◽  
B Busche ◽  
H Nau ◽  
D Eikel ◽  
L Schweigerer ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Hdac Inhibitors ◽  
Leukemia Cells
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