scholarly journals Evolving Trends in Estrogen Receptor Biology

10.5772/25956 ◽  
2012 ◽  
Author(s):  
Raghava Varman
Keyword(s):  
Estrogen Receptor ◽  
Receptor Biology

scholarly journals MTA family of coregulators in nuclear receptor biology and pathology

2007 ◽  
Vol 5 (1) ◽  
pp. nrs.05010 ◽  
Author(s):  
Bramanandam Manavathi ◽  
Kamini Singh ◽  
Rakesh Kumar
Keyword(s):  
Estrogen Receptor ◽  
Nuclear Receptors ◽  
Histone Deacetylases ◽  
Target Genes ◽  
Estrogen Signaling ◽  
Dependent Manner ◽  
Nucleosome Remodeling ◽  
Associated Proteins ◽  
Receptor Biology ◽  
Receptor Transactivation

Nuclear receptors (NRs) rely on coregulators (coactivators and corepressors) to modulate the transcription of target genes. By interacting with nucleosome remodeling complexes, NR coactivators potentiate transcription, whereas corepressors inhibit transcription of the target genes. Metastasis-associated proteins (MTA) represent an emerging family of novel NR coregulators. In general, MTA family members form independent nucleosome remodeling and deacetylation (NuRD) complexes and repress the transcription of different genes by recruiting histone deacetylases onto their target genes. However, MTA1 also acts as a coactivator in a promoter-context dependent manner. Recent findings that repression of estrogen receptor transactivation functions by MTA1, MTA1s, and MTA2 and regulation of MTA3 by estrogen signaling have indicated the significance of these proteins in NR signaling. Here, we highlight the action of MTA proteins on NR signaling and their roles in pathophysiological conditions.

1625: Role of Estrogen Receptor β in the Regulation of Sexual Behavior in Male Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 429-429
Author(s):  
Masayoshi Nomura ◽  
Naohiro Fujimoto ◽  
Donald W. Pfaff ◽  
Sonoko Ogawa ◽  
Tetsuro Matsumoto
Keyword(s):  
Estrogen Receptor ◽  
Sexual Behavior ◽  
Estrogen Receptor Β ◽  
Male Mice
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