scholarly journals Amniotic Fluid Progenitor Cells and Their Use in Regenerative Medicine

10.5772/25825 ◽  
2011 ◽  
Author(s):  
Stefano Da ◽  
Roger E. De Filippo ◽  
Laura Peri
Keyword(s):  
Regenerative Medicine ◽  
Amniotic Fluid ◽  
Progenitor Cells

scholarly journals Human term amniotic fluid: a novel source of stem cells for regenerative medicine

2018 ◽  
Vol 219 (3) ◽  
pp. 308-309 ◽  
Author(s):  
Cara D. Dolin ◽  
Michael K. Chan ◽  
Ross S. Basch ◽  
Bruce K. Young
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Amniotic Fluid

scholarly journals Genetic Modification of Primate Amniotic Fluid-Derived Stem Cells Produces Pancreatic Progenitor Cells in vitro

2013 ◽  
Vol 197 (4) ◽  
pp. 269-282 ◽  
Author(s):  
Yu Zhou ◽  
David L. Mack ◽  
J. Koudy Williams ◽  
Sayed-Hadi Mirmalek-Sani ◽  
Emily Moorefield ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Progenitor Cells ◽  
Genetic Modification ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells

scholarly journals Intramuscular Transplantation of Pig Amniotic Fluid-Derived Progenitor Cells Has Therapeutic Potential in a Mouse Model of Myocardial Infarction

2015 ◽  
Vol 24 (6) ◽  
pp. 1003-1012 ◽  
Author(s):  
Shao-Yu Peng ◽  
Chih-Jen Chou ◽  
Po-Jen Cheng ◽  
Tse-Yang Tseng ◽  
Winston Teng-Kui Cheng ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mouse Model ◽  
Amniotic Fluid ◽  
Progenitor Cells ◽  
Therapeutic Potential

scholarly journals Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells

2015 ◽  
Vol 20 (9) ◽  
pp. 1074-1083 ◽  
Author(s):  
Yoshikuni Tabata ◽  
Norio Murai ◽  
Takeo Sasaki ◽  
Sachie Taniguchi ◽  
Shuichi Suzuki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Progenitor Cells ◽  
Cell Fate ◽  
Bioactive Compounds ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Screening System ◽  
Human Stem Cells ◽  
Neural Stem Progenitor Cells

Stem cell research has been progressing rapidly, contributing to regenerative biology and regenerative medicine. In this field, small-molecule compounds affecting stem cell proliferation/differentiation have been explored to understand stem cell biology and support regenerative medicine. In this study, we established a multiparametric screening system to detect bioactive compounds affecting the cell fate of human neural stem/progenitor cells (NSCs/NPCs), using human fetal hippocampal NSCs/NPCs, HIP-009 cells. We examined effects of 410 compounds, which were collected based on mechanisms of action (MOAs) and chemotypes, on HIP-009’s cell fate (self-renewal, neuronal and astrocytic differentiation) and morphology by automated multiparametric assays and profiled induced cellular phenotypes. We found that this screening classified compounds with the same MOAs into subgroups according to additional pharmacological effects (e.g., mammalian target of rapamycin complex 1 [mTORC1] inhibitors and mTORC1/mTORC2 dual inhibitors among mTOR inhibitors). Moreover, it identified compounds that have off-target effects under matrix analyses of MOAs and structure similarities (e.g., neurotropic effects of amitriptyline among tri- and tetracyclic compounds). Therefore, this automated, medium-throughput and multiparametric screening system is useful for finding compounds that affect the cell fate of human NSCs/NPCs for supporting regenerative medicine and to fingerprint compounds based on human stem cells’ multipotency, leading to understanding of stem cell biology.

scholarly journals Prenatally Fabricated Autologous Human Living Heart Valves Based on Amniotic Fluid Derived Progenitor Cells as Single Cell Source

Circulation ◽  
2007 ◽  
Vol 116 (11_suppl) ◽  
pp. I-64-I-70 ◽  
Author(s):  
D. Schmidt ◽  
J. Achermann ◽  
B. Odermatt ◽  
C. Breymann ◽  
A. Mol ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Single Cell ◽  
Progenitor Cells ◽  
Heart Valves ◽  
Cell Source
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